Rchr
J-GLOBAL ID：200901013210371837   Update date: Apr. 14, 2024

Osamu Nagano

ナガノ オサム | Osamu Nagano
Affiliation and department：
Fujita Health University Division of Gene Regulation, Cancer Center

About Fujita Health University Division of Gene Regulation, Cancer Center


Job title： Professor
Research field  (1)： Pathobiochemistry
Research keywords  (1)： Tumor biology
Research theme for competitive and other funds  (8)：
  • 2021 - 2024 Elucidation of mechanisms of xCT-mediated cancer therapy resistance accompanied with metabolic reprograming and cancer stem cell property
  • 2021 - 2023 Development of the therapy targeted to the vulnerability of SMARCA4-mutant lung cancer cells to ferroptosis
  • 2017 - 2020 Elucidation of the mechanism of the induction of ferroptosis by xCT inhibitor and its antitumor effect in small cell lung cancer
  • 2016 - 2018 Development of therapeutic strategry breaking resistance to oxidative stress in glioma
  • 2012 - 2015 Development of cancer therapy targeting the metabolism activated by EpCAM in cancer stem cells.
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Papers (77)：
  • Fumimasa Kitamura, Takashi Semba, Noriko Yasuda-Yoshihara, Kosuke Yamada, Akiho Nishimura, Juntaro Yamasaki, Osamu Nagano, Tadahito Yasuda, Atsuko Yonemura, Yilin Tong, et al. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI insight. 2023. 8. 20
  • 山田 晃亮, 北村 文優, 千場 隆, 魏 峰, 永野 修, 西村 朗甫, トン 依霖, 安田 忠仁, 安田 法子, 山崎 淳太郎, et al. 膵癌腫瘍関連線維芽細胞における乳酸代謝の役割についての検討(Investigation of the role of the lactate metabolism in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma). 日本癌学会総会記事. 2023. 82回. 565-565
  • 今枝 慶蓉, 増田 健太, 永井 晋平, 田村 友宏, 杉原 英志, 山崎 淳太郎, 大槻 雄士, 信末 博行, 千代田 達幸, 小林 佑介, et al. 新規マウスモデルを用いた高異型度漿液性癌の予後不良に関連するバイオマーカーの同定(Identification of biomarkers associated to poor prognosis in high-grade serous carcinoma using novel mouse models). 日本癌学会総会記事. 2023. 82回. 1044-1044
  • 増田 健太, 阪埜 浩司, 青木 大輔, 山上 亘, 佐谷 秀行, 永野 修. 乳癌・卵巣癌研究の最前線 遺伝子改変オルガノイドモデルとヒトサンプルを用いた化学療法後の卵巣癌残存腫瘍細胞の解析(Frontiers of Breast and Ovarian Cancers Analysis of residual ovarian cancer cells using the genetically engineered organoids model and human samples). 日本癌学会総会記事. 2023. 82回. 1652-1652
  • Akiyama T, Yasuda T, Uchihara T, Yasuda-Yoshihara N, Tan BJY, Yonemura A, Semba T, Yamasaki J, Komohara Y, Ohnishi K, et al. Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors. Cancer research. 2022. 83. 5. 753-770
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MISC (64)：
  • Shogo Okazaki, Yuki Nakano, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Ryo Goitsuka, Hideyuki Saya, Osamu Nagano. Transcription factor FOXA1 is a negative regulator for xCT-dependent tumor formation in oral cancer. CANCER SCIENCE. 2022. 113. 1324-1324
  • 永井 晋平, 増田 健太, 田村 友宏, 大槻 雄士, 推名 健太郎, 信末 博行, 赤羽 智子, 千代田 達幸, 小林 佑介, 阪埜 浩司, et al. p53の機能障害はマウス卵管オルガノイドの分化を阻害する. 日本癌学会総会記事. 2021. 80回. [J5-6]
  • Shintaro Nakamura, Hiroyuki Ozawa, Juntaro Yamasaki, Shogo Okazaki, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Osamu Nagano, Mariko Sekimizu, Shin Saito, et al. Pimozide combined with paclitaxel demonstrates a significant antitumor effect in head and neck squamous cell carcinoma. CANCER RESEARCH. 2020. 80. 16
  • 推名 健太郎, 山崎 淳太郎, 大槻 雄士, 平田 雄紀, 岡崎 章悟, 土橋 賢司, サンペトラ・オルテア, 光石 陽一郎, 高橋 史行, 高橋 和久, et al. 小細胞肺癌において、xCTはがん幹細胞性に寄与する(xCT confers cancer stem-like properties in small cell lung cancer cells). 日本癌学会総会記事. 2019. 78回. E-1102
  • Shohei Kamenori, Kentaro Suina, Juntaro Yamasaki, Subaru Shintani, Yuji Otsuki, Yuki Hirata, Shogo Okazaki, Kenji Tsuchihashi, Oltea Sampetrean, Yoichiro Mitsuishi, et al. SLC7A11 expression confers cancer stem-like properties in small cell lung cancer cells. CANCER RESEARCH. 2019. 79. 13
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Patents (4)：
  • 抗腫瘍剤及び配合剤
  • がん幹細胞の増殖抑制剤および細胞内活性酸素蓄積誘導剤
  • ダイヤモンドマイクロ電極を用いた生体内pH測定装置及び方法
  • ダイヤモンド微小電極を用いた還元型グルタチオンの測定装置
Lectures and oral presentations  (59)：
  • Therapeutic targeting of redox system in cancer stem cells
    (The 80th Annual Meeting of the Japanese Cancer Association 2021)
  • xCT阻害剤抵抗性を示す癌細胞に対してxCT阻害剤と合成致死を誘導する薬 剤の同定
    (第42回日本分子生物学会年会 2019)
  • 癌細胞に鉄依存性細胞死を誘導するxCT標的治療とその抵抗性を克服する薬剤の探索
    (第41回日本分子生物学会年会 2018)
  • Cancer treatment strategy targeting antioxidant system potentiated by CD44v-xCT in stem-like cancer cells.
    (BioMedical Transporters 2017 2017)
  • Cancer treatment strategy targeting antioxidant system potentiated by CD44v-xCT in stem-like cancer cells.
    (ALBERTA-JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT (AMED) WORKSHOP FOR MEDICAL INNOVATION 2017)
ｍore...
Education (2)：
  • 2001 - 2005 Kumamoto University School of medicine
  • 1993 - 1999 Hiroshima University Faculty of dentistry
Professional career (1)：
  • 医学博士 (熊本大学)
Work history (5)：
  • 2023/04 - 現在 Fujita Health University Division of Gene Regulation, Cancer Center Professor
  • 2018/05 - 2023/03 Keio University School of Medicine associate professor
  • 2012/04 - 2018/04 Keio University School of Medicine assistant professor
  • 2007/04 - 2012/03 Keio University School of Medicine assistant professor
  • 1999/06 - 2001/03 Kyushu University Faculty of Dental Science resident
Awards (1)：
  • 2011/10 - Japanese cancer association Incitement Award of the Japanese Cancer Association 癌幹細胞マーカーCD44の機能解析
Association Membership(s) (2)：
Japanese Cancer Association ,  日本分子生物学会
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