Takada Kimihiko

• 血管内皮細胞機能と血栓症に関する研究
• Study on the functions of endothelial cells in thrombosis

• Yuki Hirata, Yutaka Masuda, Hideki Kakutani, Toshiyuki Higuchi, Kimihiko Takada, Akira Ito, Yoshio Nakagawa, Hidemi Ishii. Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappa B, AP-1, and Sp1 activation. BIOCHEMICAL PHARMACOLOGY. 2008. 75. 7. 1504-1514
• Yuki Hirata, Yutaka Masuda, Hideki Kakutani, Toshiyuki Higuchi, Kimihiko Takada, Akira Ito, Yoshio Nakagawa, Hidemi Ishii. Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappa B, AP-1, and Sp1 activation. BIOCHEMICAL PHARMACOLOGY. 2008. 75. 7. 1504-1514
• Kazuya Murata, Toshiyuki Higuchi, Kimihiko Takada, Koji Oida, Shuichi Horie, Hidemi Ishii. Verotoxin-1 stimulation of macrophage-like THP-1 cells up-regulates tissue factor expression through activation of c-Yes tyrosine kinase: Possible signal transduction in tissue factor up-regulation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2006. 1762. 9. 835-843
• H Ishii, T Tezuka, H Ishikawa, K Takada, K Oida, S Horie. Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RAR beta-RXR alpha- heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter. BLOOD. 2003. 101. 12. 4765-4774
• H Ishii, T Tezuka, H Ishikawa, K Takada, K Oida, S Horie. Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RAR beta-RXR alpha- heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter. BLOOD. 2003. 101. 12. 4765-4774

ｍore...

• - 1982 Showa Pharmaceutical University
• - 1982 Showa Pharmaceutical University
• - 1980 Showa Pharmaceutical University Faculty of Pharmaceutical Sciences Department of Pharmacy
• - 1980 Showa Pharmaceutical University Faculty of Pharmaceutical Science

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日本血栓止血学会 ,  日本過酸化脂質・フリーラジカル学会 ,  日本生化学会 ,  日本薬学会 ,  The Japanese Society of Lipid Peroxide and Free Radical Research ,  The Japanese Society on Thrombosis and Hemostasis ,  The Japanese Cancer Association ,  The Japanese Biochemical Society ,  The Pharmaceutical Society of Japan