Rchr
J-GLOBAL ID：200901014184379430   Update date: Apr. 02, 2024

Nishina Hiroshi

ニシナ ヒロシ | Nishina Hiroshi
Affiliation and department：
Tokyo Medical and Dental University Medical Research Institute, Department of Developmental and Regenerative Biology

About Tokyo Medical and Dental University Medical Research Institute, Department of Developmental and Regenerative Biology


Job title： Professor
Homepage URL  (1)： http://www.tmd.ac.jp/mri/dbio/index.html
Research field  (4)： Pharmaceuticals - health and biochemistry ,  Developmental biology ,  Cell biology ,  Molecular biology
Research keywords  (15)： ストレス ,  シグナル伝達 ,  恒常性維持 ,  肝臓形成 ,  個体・器官サイズ ,  再生 ,  発生 ,  Knockout mouse ,  Medaka ,  Model organism ,  Signal transduction ,  Stress ,  Liver formation ,  Regeneration ,  Development
Research theme for competitive and other funds  (75)：
  • 2023 - 2027 Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy
  • 2020 - 2023 Elucidation of the roles of the Hippo-YAP signaling pathway in regulating cell tension in liver development and regeneration
  • 2018 - 2020 ドライバー遺伝子の痕跡が消失するがん発症機構の解明
  • 2014 - 2017 Analysis of cellular quality control in liver tissue formation
  • 2013 - 2016 Establishment of a novel method for retinal cell differentiation using pediatric eye ball and small compound
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Papers (151)：
  • Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima, Hiroshi Nishina. Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation. Stem Cells. 2023
  • Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, Shigeomi Shimizu. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023. 26. 7. 107218-107218
  • Noriyuki Azuma, Tadashi Yokoi, Taku Tanaka, Emiko Matsuzaka, Yuki Saida, Sachiko Nishina, Miho Terao, Shuji Takada, Maki Fukami, Kohji Okamura, et al. Integrator complex subunit 15 controls mRNA splicing and is critical for eye development. Human Molecular Genetics. 2023
  • Chiyumi Oda, Kenya Kamimura, Osamu Shibata, Shinichi Morita, Yuto Tanaka, Toru Setsu, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, et al. HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. Biochemistry and biophysics reports. 2022. 32. 101352-101352
  • Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, et al. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflammation and regeneration. 2022. 42. 1. 49-49
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MISC (165)：
  • 辻本 和峰, 橋本 貢士, 榛澤 望, 川堀 健一, 袁 勲梅, 長岡 勇也, 仁科 博史, 畑田 出穂, 山田 哲也, 小川 佳宏. エピゲノム改変動物を用いたFibroblast growth factor 21(FGF21)遺伝子DNAメチル化の機能的意義解明. 糖尿病. 2021. 64. Suppl.1. 助成-7
  • 榛澤 望, 橋本 貢士, 袁 勲梅, 辻本 和峰, 川堀 健一, 長岡 勇也, 仁科 博史, 畑田 出穂, 山田 哲也, 小川 佳宏. Fibroblast growth factor(FGF)21遺伝子特異的DNA脱メチル化によるエピゲノム改変細胞および動物の樹立. 日本内分泌学会雑誌. 2020. 96. 1. 231-231
  • Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Norihiro Sakai, Takuro Nagoya, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Akira Sakamaki, Hiroteru Kamimura, et al. Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma. Cancers. 2020. 12. 2
  • 上村顕也, 横尾健, 阿部寛幸, 三浦浩美, 大塚正人, 尾田雅文, 仁科博史, 寺井崇二. ハイドロダイナミック遺伝子導入法による肝線維化・肝癌に対する遺伝子治療研究. 肝細胞研究会プログラム・抄録集. 2020. 27th
  • Hirayama J, Nishina H. Shedding light on zebrafish daily rhythms: Clock gene functions revealed. EurekAlert. 2019
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Books (8)：
  • 分子細胞生物学 第9版 (Lodish et al.)
    東京化学同人 2023
  • 薬学用語辞典
    東京化学同人 2012
  • 生物学事典
    東京化学同人 2010
  • シグナル伝達の分子機構: ベーシックマスター生化学
    オーム社 2008
  • sek1(SAPK/ERK Kinase-1)
    1997
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Education (5)：
  • - 1990 The University of Tokyo Graduate School, Division of Natural Science
  • - 1990 The University of Tokyo
  • - 1990 The University of Tokyo Graduate School, Division of Science
  • - 1985 The University of Tokyo Faculty of Science
  • - 1985 The University of Tokyo Faculty of Science
Professional career (2)：
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Work history (9)：
  • 2020/04/01 - 現在 Tokyo Medical and Dental University Medical Research Institute Director
  • 2005/01/01 - 現在 東京医科歯科大学 難治疾患研究所 教授
  • 2005/01/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Life Science and Technology Life Science and Technology Developmental and Regenerative Biology Professor
  • 2005/01/01 - 現在 Tokyo Medical and Dental University Medical Research Institute Pathophysiology Developmental and Regenerative Biology Professor
  • 1998/05/01 - 2004/12/30 東京大学 薬学部 助教授
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Committee career (4)：
  • 2023/01 - 現在 The Molecular Biology Society of Japan board of directors
  • 日本Cell Death学会 監事・評議員
  • 日本生化学会 常務理事
  • 肝細胞研究会 代表世話人
Association Membership(s) (8)：
日本肝臓医生物学研究会 ,  アメリカ生化学会 ,  肝細胞研究会 ,  日本肝臓学会 ,  日本薬学会 ,  日本生化学会 ,  日本分子生物学会 ,  日本癌学会
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