Rchr

J-GLOBAL ID：200901014800820498 Update date: Apr. 17, 2024

Sakai Eiko

サカイエイコ | Sakai Eiko

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Oral medicine

Research keywords (4)： Dental pharmacology , membrane traffic , oxidative stress , osteoclast

Research theme for competitive and other funds (60)：

2023 - 2026 Functional analysis of a novel membrane transport factor in metabolic bone diseases
2023 - 2026 変異型Rufy4を発現する破骨細胞の細胞外小胞を介した骨吸収調節機構の解明と応用
2023 - 2024 エイ胎仔の胚休眠後の子宮ミルク分泌メカニズムを液中電顕観察から探る
2020 - 2023 Functional and pathological analyses of inflammatory bone destruction disease by a novel Rab protein
2020 - 2023 a novel therapeutic agent for osteoporosis having both antioxidant activity and PDE inhibitory activity

2019 - 2022 Identification and functional elucidation of a novel transport factor in osteoclasts

2019 - 2022 酸化ストレスと骨吸収に関連した新規オートファジー制御因子の機能解明

2017 - 2021 Involvement of 12 / 15-LOX with intracellular organelle degradation mechanism in root resorption

2019 - 2020 カフェストールの骨破壊性疾患に対する治療効果と血中コレステロール値への影響

2017 - 2020 Discovery of a novel gene regulating membrane trafficking of immune cells and elucidation of its pathology

2017 - 2020 Genome-wide search for genes of Type IX secretion system by effective Tn-Seq analysis

2016 - 2019 Development of Supplement having anti-cancer action based on Flavonoid

2016 - 2019 Keap1/Nrf2による骨代謝制御機構の解明とインシリコ創薬への応用

2016 - 2018 Analyses using bioimaging of invasion and colonization mechanisms by periodontal bacteria in the liver

2016 - 2018 破骨細胞におけるリソソーム分泌機構の制御因子の同定と分子メカニズムの解析

2015 - 2018 Examination of new medicine for bone metabolism by investigation of potential natural drugs in China

2014 - 2016 Development of detection systems for polyphenols that inhibit osteoclast formation and its applications

2013 - 2016 Analysis of new functions of an intracellular protease in epithelial cancers

2013 - 2016 Elucidation of the mechanism of systemic diseases by a periodontal pathogen in the intracellular transport

2013 - 2016 Nrf2 による破骨細胞制御機構の解明と分子標的に着目した天然物リガンドの探索

2012 - 2015 Phylogenetic and biochemical approach for identifying the chronic proinflammatory proteins accumulated in protease-deficient species and individuals

2012 - 2015 Cell biological analysis of membrane protein induced by glucocorticoid

2012 - 2014 Mechanistic analysis of periodontal bacteria attached on cardiovascular tissues by live-imaging

2010 - 2013 Elucidation of molecular mechanisms of osteoclastogenesis by iron

2010 - 2012 Pathological analysis of epithelial cells in periodontitis

2009 - 2011 The role of cathepsin E in osteoclast and the research for substrate molecule binding with cathepsin E

2007 - 2011 Elucidation of autophagy in development of periodontitis and its application of therapy

2008 - 2010 Role(s) of pepstatin A-sensitive aspartic proteinases in osteoclast differentiation

2007 - 2009 歯周病細菌アドヘジン蛋白とその内部領域ペプチドを利用する創薬にむけた基礎的研究

2007 - 2008 Mechanism of action for proteinase as drug target in bone diseases

2006 - 2007 Study for gignipain-related adhesins of Periodontal pathogen, Porphyromonas gingivalis for its platelet aggregation activity

2005 - 2007 Molecular Mechanisms of Interaction between Periodontitis and Cardiovascular and Bone Metabolic Disorders

2007 - 鉄代謝分子を介した破骨細胞の分化制御

2007 - Regulation of Osteoclastogenesis mediated by iron-associated molecules

2005 - 2006 Study of membrane transport system in proteinase produced from Porphyromonas gingivalis

2003 - 2005 Study of the correlation bone in osteoclast resorption with atopic disease

2003 - 2004 Establishment of protein expression system in Porphyromonasi gingivalis

2002 - 2003 FUNCTION OF ANNEXIN FAMILY PROTEINS IN OSTEOCLAST DIFFERENTIATION AND ACTIVATION

2003 - スフィンゴ糖脂質による破骨細胞の機能制御

2003 - Regulation of Osteoclastogenesis by Glycosphingolipids

1999 - 2002 破骨細胞の小胞輸送

1999 - 2002 Vesicle transport of osteoclast

2002 - Porphyromonas gingivalisの接着ドメインによる血球凝集作用

2002 - Hemagglutination by Adhesin domain of Porphyromonas gingivalis

2000 - 2001 ミオシンVIの破骨細胞における機能:細胞内小胞輸送の方向性と波状縁形成のメカニズム

1999 - 2001 Design and application of new fluoroescent substrate against membrane-bound processing enzyme

2001 - スフィンゴ糖脂質による破骨細胞の機能制御

2001 - Regulation of Osteoclastogenesis by Glycosphingolipids

1998 - 1999 A novel method for fluorescence microscopic demonstration of caspase activity

1997 - 1999 Roles of metalloprotease-disintegrins in osteoclastogenesis

1997 - 1999 MGPの精製と抗体作成

1997 - 1999 Purification and antibody preparation of Matrix Gla Protein (MGP)

1997 - 1998 破骨細胞の波状縁膜蛋白質に対するモノクローナル抗体セットの作製

1996 - 1997 Quality control mechanism for secretory proteins in intracellular protein sorting pathway

1995 - 1997 alpha2 macroglobulin の精製とカテプシンE による切断部位の決定

1995 - 1997 Purification of alpha2 macroglobulin, and determination of processing site of alpha2 macroglobulin by cathepsin E

1992 - 1994 Significance of osteocalcin in bone metabolism

1984 - 1992 カテプシンE の精製と性質づけ

1984 - 1992 Purification and characterization of cathepsin E

1990 - 1991 STUDIES ON FUNCTION OF LYSOSOMAL ENZYMES IN MATURATION AMELOBLASTS IN RAT

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Papers (78)：

Ayuko Tanimoto, Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Shun Oyakawa, Yusuke Ono, Noriaki Yoshida, Takayuki Tsukuba. Rab44 negatively regulates myoblast differentiation by controlling fusogenic protein transport and mTORC1 signaling. Journal of cellular biochemistry. 2023
Shun Oyakawa, Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Mayuko Noguromi, Ayuko Tanimoto, Yusuke Ono, Hiroshi Murata, Takayuki Tsukuba. Rab44 deficiency accelerates recovery from muscle damage by regulating mTORC1 signaling and transport of fusogenic regulators. Journal of cellular physiology. 2023
Fatima Farhana, Eiko Sakai, Yu Koyanagi, Yu Yamaguchi, Mohammad Ibtehaz Alam, Kuniaki Okamoto, Takayuki Tsukuba. Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase. Molecular biology reports. 2023
Sakai Eiko, Sato Mari, Sato Chikara. Commentary: Liquid-phase ASEM imaging of cellular and structural details in cartilage and bone formed during endochondral ossification: Keap1-deficient osteomalacia. J Orthopedics & Orthopedic Surg. 2022. 3. 3. 2-6
Manh Tien Tran, Yuka Okusha, Kaung Htike, Chiharu Sogawa, Takanori Eguchi, Tomoko Kadowaki, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto. HSP90 drives the Rab11a-mediated vesicular transport of the cell surface receptors in osteoclasts. Cell Biochemistry & Function. 2022. 40. 8. 838-855

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MISC (62)：

山口優, 門脇知子, 坂井詠子, 野黒美麻由子, 親川駿, 日浅匠, 馬渡遥香, 筑波隆幸. Rab44はコラーゲン抗体誘発性関節炎において炎症反応を制御する. 2023
坂井詠子, 小柳悠, Farhana Fatima, 山口優, 筑波隆幸. Rufy4のRUNドメイン欠失変異体は糸状仮足形成を促進し破骨細胞の骨吸収を抑制する. 歯科基礎医学会抄録集. 2023
小柳悠, 坂井詠子, 山口優, ファルハナ・ファティマ, 山田志津香, 介田圭, 江越貴文, 平曜輔, 村田比呂司, 筑波隆幸. Dennd2cは破骨細胞分化を負に制御する. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. 1-271
谷本あゆ子, 山口優, 門脇知子, 坂井詠子, 親川駿, 筑波隆幸. Rab44はmTORC1シグナルを制御することで筋芽細胞の分化を負に制御する. 2023. P1. 2-17
親川駿, 山口優, 門脇知子, 坂井詠子, 野黒美麻由子, 谷本あゆ子, 筑波隆幸. Rab44は筋衛星細胞におけるmTORC1シグナル伝達と融合制御因子の輸送の調節により筋再生を負に制御する. 歯科基礎医学会抄録集. 2023. P1. 3-38

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Books (2)：

Studies in Natural Products Chemistry (edited by Atta-UR-Rahman) Volume 72
Elsevier 2022 ISBN:9780128239445
COFFEE IN HEALTH AND DISEASE PREVENTION
ACADEMIC PRESS 2015 ISBN:9780124095175

Lectures and oral presentations (105)：

Delayed hypertrophy and vascular invasion of resting-chondrocyte zone in Keap1 deficient mice observed by atmospheric scanning electron microscopy in liquid
(Gordon Research Conferences 2024)
Observation of ossification and osteoclasts in bones in aqueous buffer by ASEM
(2021)
Liquid-phase imaging of bone development and calcification by atmospheric scanning electron microscopy (ASEM): Application to immunolabeling and rapid tissue observation of genetically modified mouse
(Microscopy & Microanalysis 2021 virtual meeting 2021)
Observation of chondrocytes and their ossification in bones in aqueous buffer by ASEM
(2021)
observation of biofilm and bone metabolism in aqueous liquid using immuno-labeled ASEM
(2020)

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Works (10)：

膜輸送関連分子による破骨細胞分化制御
2014 -
酸化ストレス応答系による破骨細胞分化制御
2014 -
歯周病における上皮細胞の病態解析
2010 - 2013
鉄を介した破骨細胞分化調節機構の分子メカニズムを解明する
2010 - 2013
破骨細胞におけるアスパラギン酸プロテアーゼの機能
2008 - 2011

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Education (1)：

- 1984 Nagasaki University School of Pharmaceutical Sciences

Professional career (1)：

博士(歯学) (長崎大学)

Work history (5)：

2007 - 現在 Nagasaki University Graduate School of Biomedical Sciences
2004 - 2007 Nagasaki University Graduate School of Biomedical Sciences
1995 - 2004 Nagasaki University School of Dentistry
1993 - 1993 米国ニューヨーク州メモリアルスローンケタリング癌センターボランティアスタッフ
1984 - 1992 Nagasaki University School of Dentistry

Association Membership(s) (6)：

日本鉄バイオサイエンス学会 , 日本細菌学会 , 日本骨代謝学会 , 日本生化学会 , 歯科基礎医学会 , 日本薬理学会

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