Yamashita Shun-ichi

ヤマシタシュンイチ | Yamashita Shun-ichi

Affiliation and department：
Homepage URL (1)： https://www.med.niigata-u.ac.jp/mit/

Research field (4)： Laboratory animal science , Molecular biology , Tumor biology , Cell biology

Research keywords (7)： peroxisome , mitophagy , mitochondria , ペキソファジー , オートファジー , Pexophagy , Autophagy

Research theme for competitive and other funds (12)：

2022 - 2025 レセプター依存的マイトファジーの誘導制御と生理機能の解明
2022 - 2025 Elucidation of the molecular mechanism of the mitophagy contributing to the drug resistance and its application to chemotherapy
2017 - 2020 Morphological analysis of mitochondria during mitophagy
2018 - 2019 Molecular mechanisms and physiological role of mitochondria DNA in mitochondria-related disease
2017 - 2019 Molecular mechanisms and physiological role of degradation of mitochondria DNA by autophagy

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Papers (39)：

Shun-Ichi Yamashita, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Keiichi Inoue, Kentaro Furukawa, Tomoyuki Fukuda, David C Chan, Tomotake Kanki. Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species. Cell death and differentiation. 2024
Kyota Aoyagi, Chiyono Nishiwaki, Yoko Nakamichi, Shun-ichi Yamashita, Tomotake Kanki, Mica Ohara-Imaizumi. Imeglimin mitigates the accumulation of dysfunctional mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β-cells from db/db mice. Scientific Reports. 2024. 14. 1
Fukuda T, Saigusa T, Furukawa K, Inoue K, Yamashita SI, Kanki T. Hva22, a REEP family protein in fission yeast, promotes reticulophagy in collaboration with a receptor protein. Autophagy. 2023
Tomoyuki Fukuda, Kentaro Furukawa, Tatsuro Maruyama, Shun-ichi Yamashita, Daisuke Noshiro, Chihong Song, Yuta Ogasawara, Kentaro Okuyama, Jahangir Md Alam, Manabu Hayatsu, et al. The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy. Molecular Cell. 2023
Shiori Akabane, Kiyona Watanabe, Hidetaka Kosako, Shun-ichi Yamashita, Kohei Nishino, Masahiro Kato, Shiori Sekine, Tomotake Kanki, Noriyuki Matsuda, Toshiya Endo, et al. TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria. Cell Reports. 2023. 112454-112454

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MISC (22)：

山下俊一. 体温調節におけるミトコンドリア分解の重要性とその分子機構. 温度ストレスにおける生体応答ダイナミクス. 2023
井上敬一, 山下俊一, 神吉智丈. 哺乳類におけるミトコンドリアオートファジーの分子機構. 実験医学増刊. 2019. 37. 12. 58-64
山下俊一, 神吉智丈. 【オートファジーと疾患】ミトコンドリア恒常性の維持とマイトファジー. BIO Clinica. 2018. 33. 7. 617-621
CHERNYSHOVA Kseniia, CHERNYSHOVA Kseniia, 山下俊一, 五十嵐遼子, 五十嵐遼子, 福地健郎, 神吉智丈. 広義原発開放隅角緑内障の原因遺伝子オプチニューリン遺伝子の変異とミトコンドリア恒常性維持機構との関係. 日本緑内障学会抄録集. 2018. 29th
吉河万里, 山下俊一, 奥公秀, 阪井康能. Lag-phase autophagyにおけるイノシトールリン脂質とAtg分子群の機能解析. 日本農芸化学会大会講演要旨集. 2010. 2010. 199

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Books (4)：

実験医学増刊Vol.37 No.12:ミトコンドリアと疾患・老化
羊土社 2019 ISBN:9784758103800
BIO Clinica: Autophagy and Human Diseases
Hokuryukan & New science 2018
実験医学:ユビキチン化を介したオルガネロファジー
Youdosha 2017 ISBN:9784758101653
PNE: Ubiquitin proteasome system and Autophagy
Kyoritsu 2006

Lectures and oral presentations (30)：

ミトコンドリア分解欠損細胞に見られる酸化ストレス応答
(第96回日本生化学会大会 2023)
レセプター介在性マイトファジーの分子機構
(第94回日本生化学会大会 2021)
The role of mitophagy-receptor proteins in mitophagy
(The 42nd Annual Meeting of the Molecular Biology Society of Japan 2019)
The contribution of mitophagy to thermogenesis in adipose tissues
(第4回温度生物学若手の会 2018)
Mitochondrial division is associated with autophagosome formation during mitophagy
(Keystone Symposia Mitochondrial Biology, Selective Autophagy 2018)

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Education (3)：

2003 - 2007 Kyoto University Graduate School of Agriculture Division of Applied Life Sciences
2001 - 2003 Tokyo University of Agriculture Fuculty of Applied Bioscience Department of Applied Biology and Chemistry
1997 - 2001 Tokyo University of Agriculture Fuculty of Applied Bioscience Department of Applied Biology and Chemistry

Professional career (1)：

Master(Agriculture Chemistry) (Tokyo University of Agriculture)

Work history (9)：

2024/04 - 現在 Kyushu University Graduate School of Medical Sciences
2024/04 - 現在 Niigata University Graduate School of Medical and Dental Sciences
2016/07 - 2024/03 Niigata University Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences Assistant Professor
2018/10 - 2019/10 California Institute of Technology Division of Biology and Biological Engineering Visiting Associate
2014/01 - 2016/06 Niigata University Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences Research Assistant Professor

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Awards (3)：

2017/09 - Niigata University President's Award Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy
2013 - The Japanese Biochemical Society 鈴木紘一メモリアル賞 Induction of peroxisome degradation by overloading of peroxisome membrane protein in mammalian cells
2011 - The Japanese Biochemical Society Samuro Kakiuchi Memorial Research Award for Young Scientists Quality control of peroxisome membrane proteins

Association Membership(s) (4)：

The Molecular Biology Society of Japan , JAPAN SOCIETY FOR CELL BIOLOGY , THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE , THE JAPANESE BIOCHEMICAL SOCIETY

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