Rchr
J-GLOBAL ID：200901015037111428
Update date: Feb. 01, 2024
Kobayashi Yoshiro
コバヤシ ヨシロウ | Kobayashi Yoshiro
Affiliation and department：
Research field (3)：
Immunology
, Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (2)：
免疫学
, Immunology
Research theme for competitive and other funds (19)：
- 2015 - 2018 The analysis of mechanism in the serious inflammatory responses induced by dead cells as aging.
- 2012 - 2015 The effect of aging on dead cells induced inflamatory responses and analysis of its mechanisms
- 1998 - 2015 Response of macrophage upon phagocytosis of apoptotic cells
- 2009 - 2011 The role of DAMPs on induction and termination of inflammatory responses induced by necrotic cells.
- 2009 - 2011 Resolution of inflammation through macrophage response to apoptotic neutrophils
- 2007 - 2008 Analysis and Application of activating mechanisms of innate immunity by neutrophils.
- 2004 - 2005 Responses in a coculture of macrophages, immature dendritic cells and apoptotic cells
- 2004 - Novel roles of neutrophils
- 2003 - 2003 p53コアクチベーターINGファミリーのがん細胞中における変異および機能の解析
- 2002 - 2003 In vivo role of the responce of macrophages after phagocytosis of appptotic cells
- 2001 - 2003 Design and Synthesis of Novel Polyester-type Dendrimers Having Cell Recognition Ability.
- 1999 - 2000 Pathological Significance of the response of macrophages after phagocytosis of apoptotic cells
- 1997 - 1998 Role of Phosphorylation on Intracellular Localization of Interleukin 1alpha
- 1997 - 1998 Regulatory Mechanism of Processing and Release of IL-lalpha
- 1996 - 1997 Development and application of novel caged compounds for clucidation of immune responce
- 1996 - 1997 Pathophysiological and pharmacological studies on chemokines
- 1995 - 1996 Coupling mechanism of processing and release of interleukin 1
- 1985 - 1987 Biochemical studies and medical application of immunoregulatory factors
- Regulation of phagocytic potential of maerophages
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Papers (66)：
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Yohko Yamaguchi, Kohei Kaida, Yusuke Suenaga, Akihito Ishigami, Yoshiro Kobayashi, Kisaburo Nagata. Age-related dysfunction of p53-regulated phagocytic activity in macrophages. Biochemical and Biophysical Research Communications. 2020. 529. 2. 462-466
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Nagayasu A, Kakinuma S, Nishimura M, Shang Y, Sunaoshi M, Tsuruoka C, Ishihara H, Shimada Y, Kobayashi Y. Kinetics of cytokine mRNA and protein expression by plastic adherent cells in the thymus after split-dose irradiation. Cytokine. 2019. 114. 92-97
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Momoko Otaki, Tetsuya Hirano, Yohko Yamaguchi, Kohei Kaida, Seiji Koshika, Kisaburo Nagata, Mayumi Nishimura, Shizuko Kakinuma, Yoshiya Shimada, Yoshiro Kobayashi. Changes in the function and phenotype of resident peritoneal macrophages after housing in an enriched environment. International Immunopharmacology. 2018. 65. 44-49
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Takahashi R, Ishigami A, Kobayashi Y, Nagata K. Skewing of peritoneal resident macrophages toward M1-like is involved in enhancement of inflammatory responses induced by secondary necrotic neutrophils in aged mice. Cellular immunology. 2016. 304-305. 44-48
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Suzuno Sekiguchi, Yui Tomisawa, Tomomi Ohki, Kumiko Tsuboi, Kisaburo Nagata, Yoshiro Kobayashi. Suppression of macrophage-mediated phagocytosis of apoptotic cells by soluble beta-glucan due to a failure of PKC-beta II translocation. INTERNATIONAL IMMUNOPHARMACOLOGY. 2016. 31. 195-199
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MISC (102)：
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Prevention of inflammatory responses upon phagocytosis of apoptotic cells by macrophages. Clinical immunology & allergology. 2009. 52. 5. 571-576
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Terumasa Umemoto, Masayuki Yamato, Yoshiko Shiratsuchi, Kenji Tsukada, Mika Utsumi, Yohei Morita, Masato Terasawa, Takehiko Shibata, Kohji Nishida, Yoshiro Kobayashi, et al. CD61 Integrin beta 3 Ligation Contributes to the Thrombopoietin-Mediated Niche Function of Mouse Hematopoietic Stem Cells. BLOOD. 2009. 114. 22. 160-160
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Yoshiro Kobayashi, Takehiko Shibata, Kisaburo Nagata. A critical role of nitric oxide in the resolution of inflammation. CYTOKINE. 2009. 48. 1-2. 29-29
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T. Shibata, K. Nagata, Y. Kobayashi. Cutting edge: a critical role of nitrogen oxide in preventing inflammation upon apoptotic cell clearance (vol 179, pg 3407, 2007). JOURNAL OF IMMUNOLOGY. 2007. 179. 10. 7185-7185
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Tskehiko Shibata, Kisaburo Nagata, Yoshiro Kobayashi. Cutting edge: A critical role of nitrogen oxide in preventing inflammation upon apoptotic cell clearance. JOURNAL OF IMMUNOLOGY. 2007. 179. 6. 3407-3411
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Books (2)：
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スタンダード免疫学
丸善 1998
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Differential gene expression, synthesis, processing and release of interleukin-1α
Elsevier 1989
Works (2)：
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樹状細胞の成熟化機構
2000 -
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Mechanism of maturation of dendritic cells
2000 -
Education (4)：
- - 1979 The University of Tokyo
- - 1979 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
- - 1970 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
- - 1970 The University of Tokyo Faculty of Science
Professional career (2)：
- (BLANK) (The University of Tokyo)
- (BLANK) (The University of Tokyo)
Work history (12)：
- 1989 - 1993 Toho University Faculty of Science
- 1989 - 1993 Associate Professor(Toho University, Fac. of
- 1993 - - 東邦大学理学部 教授
- 1993 - - Professor(Toho University, Fac. of Science)
- 1986 - 1989 アメリカ合衆国NIH 客員研究員
- 1986 - 1989 Guest Researcher(NIH, USA)
- 1980 - 1989 The University of Tokyo Faculty of Pharmaceutical Sciences
- 1980 - 1989 Assistant Professor(Tokyo University, Fac. of
- 1979 - 1980 (財)癌研究所 博士研究員
- 1979 - 1980 PD(the Cancer Institute(Tokyo))
- Science)
- Pharmaceutical Sciences)
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Association Membership(s) (6)：
日本アポトーシス研究会
, 日本癌学会
, 日本薬学会
, アメリカ免疫学会(American Association of Immunologists)
, 日本生化学会
, 日本免疫学会
