Rchr
J-GLOBAL ID：200901015173058867
Update date: Jan. 30, 2024
Tomita Mikio
トミタ ミキオ | Tomita Mikio
Affiliation and department：
Job title：
Professor
Research field (3)：
Pharmacology
, Medical biochemistry
, Clinical pharmacy
Research keywords (6)：
虚血再灌流
, 敗血症
, 生物薬剤学
, ischemia - reperfusion
, Sepsis
, Biopharmaceutics
Research theme for competitive and other funds (33)：
- 2013 - 2016 Evaluation of the intestinal secretion of indoxyl sulfate as a possible compensative excretion pathway in chronic kidney disease
- 2012 - 2015 Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methyl prednisolone and essential unsaturated fatty acids
- 2009 - 2011 Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methylpredonislone and essential fatty acids
- 2006 - 2008 New Prediction System of Infective Disease Based on Changes in Expression and Function of ABC Transporter
- 2003 - 2005 Improvement of intestinal drug absorption based on structural changes of tight junction and functional changes of P-glycoprotein
- 2001 - トランスポータ遺伝子診断に基づいたテーラーメイド薬物療法
- 1999 - 2000 Intestinal Drug Absorption and Excretion-Detoxication Using Regulation of Membrane Permeation by Oligopeptide-produced Neutrophils
- 1998 - 1999 薬物の消化管吸収制御におけるNitric Oxide の決定的役割に関する研究
- 1998 - 虚血再濯流時の腸管粘膜バリアー季の浮き関する研究
- 1998 - リポポリサッカライドの腸管粘膜を介する排泄機構に関する研究
- 1998 - 薬物の消化管吸収制御における酸化窒素の決定的役割に関する研究
- 1998 - Study on barrier dysfunction in epithelial cells during ischemia-reperfusion
- 1998 - Study on barrier dysfunction in epithelial cells during ischemia-reperfusion
- 1998 - Study on barrier dysfunction in epithelial cells during ischemia-reperfusion
- 1998 - Study on the efflux mechanism of lipopolysaccharide across epithelial cells
- 1998 - Study on the efflux mechanism of lipopolysaccharide across epithelial cells
- 1998 - Study on the efflux mechanism of lipopolysaccharide across epithelial cells
- 1998 - Study on a critical role for nitric oxide in intestinal barrier function and dysfunction
- 1998 - Study on a critical role for nitric oxide in intestinal barrier function and dysfunction
- 1998 - Study on a critical role for nitric oxide in intestinal barrier function and dysfunction
- 1995 - 1995 吸収促進剤による薬物腸管吸収の改善機構
- 1993 - 1994 Improvemrnt of Drug Absorption in Gastro intestinal Tract
- 1994 - 薬物の腸管吸収改善とその機構
- 1994 - Improvement of Intestinal Drug Absurption and its Mechanism
- 1994 - Improvement of Intestinal Drug Absurption and its Mechanism
- 1994 - Improvement of Intestinal Drug Absurption and its Mechanism
- 1993 - 1993 吸収促進剤による薬物腸管吸収の改善機構
- 1991 - 1993 Membrane Permeability and Its Improvement in Intestinal Absorption of Macromolecular Drugs
- 薬物の腸管吸収と体内動態
- 腸管粘膜透過性亢進とバクテリアトランスロケーションに関する研究
- 消化管虚血再灌流障害の機序に関する研究
- Study on Hyperpenneability of Xenobiotics and Bacterial Translocation
- Research on Mechanism in Ischemia-Reperfusion Injury in Gut
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Papers (30)：
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Kaori Morimoto, Makoto Ishii, Yoshikazu Sugimoto, Takuo Ogihara, Mikio Tomita. Inhibitory Effect of Dextran Derivatives on Multidrug Resistance-Related Efflux Transporters <i>in Vitro</i>. Biological and Pharmaceutical Bulletin. 2022. 45. 8. 1036-1042
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Kaori Morimoto, Momona Sasaki, Erika Oikawa, Maho Abe, Tatsuro Kikuchi, Makoto Ishii, Takuo Ogihara, Mikio Tomita. Intestinal Absorption of Alogliptin Is Mediated by a Fruit-Juice-Sensitive Transporter. Biological and Pharmaceutical Bulletin. 2021. 44. 5. 653-658
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Maho Kumagai, Makoto Ishii, Kaori Morimoto, Mikio Tomita. Increased membrane permeation and blood concentration of 6-carboxyfluorescein associated with dysfunction of paracellular route barrier in the small intestine of ulcerative colitis model rats. Biopharmaceutics & Drug Disposition. 2020. 41. 3. 91-100
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Aiko Iida, Shohei Ouchi, Toshio Oda, Jun Aketagawa, Yasuhiko Ito, Yusuke Takizawa, Mikio Tomita, Masahiro Hayashi. Changes of Absorptive and Secretory Transporting System of (1 -> 3) beta-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 2015. 40. 1. 29-38
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Takizawa Y, Kishimoto H, Tomita M, Hayashi M. Changes in the expression levels of tight junction components during reconstruction of tight junction from mucosal lesion by intestinal ischemia/reperfusion. European Journal of Drug Metabolism and Pharmacokinetics. 2014. 39. 211-220
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MISC (93)：
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富永 雄太, 森本 かおり, 宮本 将成, 柏倉 正太, 高橋 昂, 佐野 芳美, 矢野 健太郎, 荻原 琢男, 富田 幹雄. インドキシル硫酸の代償性排泄経路としての消化管分泌の関与. 日本腎臓病薬物療法学会誌. 2015. 4. 2. S170-S170
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Mikio Tomita, Yusuke Takizawa, Atsushi Kanbayashi, Hiroyuki Murata, Ayako Tanaka, Mariko Nakaike, Megumi Hatanaka, Tomomi Kai, Masahiro Hayashi. Suppression of efflux transporters in the intestines of endotoxin-treated rats (Retraction of vol 428, pg 1, 2012). INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2014. 465. 1-2. 479-479
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Mikio TOMITA. Impact of Intestinal Drug Absorption Enhancement in Drug Delivery System. 2012. 59. 1-11
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土井 信幸, 富田 幹雄, 木村 あおい, 林 正弘. アシルカルニチンの吸収促進作用の腸管部位差. 日本薬剤学会年会講演要旨集. 2011. 26年会. 151-151
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木村 あおい, 富田 幹雄, 土井 信幸, 新井 友里, 吉田 未紀, 林 正弘. アシルカルニチンによるTight junctionおよびABCトランスポーター機能変化における濃度依存性と寄与率の変動. 日本薬剤学会年会講演要旨集. 2011. 26年会. 171-171
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Books (7)：
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医薬品トキシコロジー
南江堂 2006
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薬の運命、スタンダード薬学シリーズ、薬と疾病
(東京化学同人)日本薬学会編 2005
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トランスポーターを介さない消化管吸収
月刊薬事 2001
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バィオミメティックスハンドブック(共著)
株式会社エヌ・ティー・エス 2000
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物理化学的視点からみた薬物の吸収
月刊薬事 2000
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Works (1)：
-
小腸移植を支えるためのドラッグデリバリーシステムを利用した虚血再灌流障害の克服
2003 -
Education (6)：
- - 1992 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmacy
- - 1992 Tokyo University of Pharmacy and Life Science Graduate School, Division of Pharmaceutical Sciences Biopharmaceuties
- - 1988 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmacy
- - 1986 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
- - 1986 Tokyo University of Pharmacy and Life Science Faculty of Pharmaceutical Science
- Tokyo University of Pharmacy and Life Science Graduate School, Division of Pharmaceutical Sciences Biopharmaceutics
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Professional career (1)：
- Philosophy of Doctor (Tokyo University of Pharmacy and Life Science)
Work history (4)：
- 1996 - 1998 Harvard Medical School
- 1988 - 1990 Akita University School of Medicine
- 1988 - 1990 Research Associate, School of
- Medicine, Akita University
Committee career (1)：
Awards (4)：
- 2003 - 吉田仲子研究賞
- 2003 - Yoshida Nakako Memorial Bioscience Study Foundation
- 2000 - 加藤記念バイオサイエンス研究振興財団
- 2000 - Kato Memorial Bioscience Study Foundation
Association Membership(s) (7)：
日本薬剤学会
, 日本炎症・再生医学会
, 日本臓器保存生物医学会
, 日本消化吸収学会
, 日本DDS学会
, 日本薬物動態学会
, 日本薬学会
