Rchr
J-GLOBAL ID：200901015588194642   Update date: Jan. 30, 2024

Doh-ura Katsumi

ドウウラ カツミ | Doh-ura Katsumi
Affiliation and department：
Tohoku University Graduate School of Medicine United Centers for Advanced Research and Translational Medicine Center for Prion Research Neurochemistry

About Tohoku University Graduate School of Medicine United Centers for Advanced Research and Translational Medicine Center for Prion Research Neurochemistry


Job title： Professor
Homepage URL  (1)： https://www.neurochemistry.med.tohoku.ac.jp
Research field  (1)： Neurology
Research keywords  (5)： プリオン ,  治療開発 ,  タンパク質コンフォメーション病 ,  ケミカルバイオロジー ,  神経化学
Research theme for competitive and other funds  (17)：
  • 2022 - 2025 セルロースエーテルが関わるプリオンに対する生体防御機構の解明
  • 2021 - 2023 異常蛋白質の排除機構に関する新原理の探究
  • 2019 - 2022 Identification of cellulose ether susceptibility genes involved in suppression of prion disease development
  • 2017 - 2020 Study for bringing a new dimension in the pathogenesis of prion disease.
  • 2016 - 2019 Analysis of host genetic factors associated with disease suppression against prion diseases.
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Papers (124)：
  • Kenta Teruya, Ayumi Oguma, Satoko Takahashi, Miki Watanabe-Matsui, Sachiyo Tsuji-Kawahara, Masaaki Miyazawa, Katsumi Doh-ura. Anti-prion activity of cellulose ether is impaired in mice lacking pre T-cell antigen receptor α, T-cell receptor δ, or lytic granule function. International Immunopharmacology. 2022. 107. 108672-108672
  • Kenta Teruya, Katsumi Doh-Ura. Therapeutic development of polymers for prion disease. Cell and tissue research. 2022. Online ahead of print. 1. 349-365
  • Kenta Teruya, Sara Iwabuchi, Yuki Watanabe, Rikiya Tsuchida, Miki Watanabe-Matsui, Hiroyuki Konno, Katsumi Doh-ura. Activities of curcumin-related compounds in two cell lines persistently infected with different prion strains. Biochimica et biophysica acta. General subjects. 2022. 1866. 4. 130094-130094
  • Kenta Teruya, Ayumi Oguma, Keita Arai, Keiko Nishizawa, Sara Iwabuchi, Miki Watanabe-Matsui, Yuji Sakasegawa, Hermann Schätzl, Sabine Gilch, Katsumi Doh-Ura. Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice. Biochemical and biophysical research communications. 2021. 560:. 105-111
  • Mingxuan Ding, Kenta Teruya, Weiguanliu Zhang, Hae Weon Lee, Jue Yuan, Ayumi Oguma, Aaron Foutz, Manuel V Camacho, Marcus Mitchell, Justin J Greenlee, et al. Decrease in Skin Prion-Seeding Activity of Prion-Infected Mice Treated with a Compound Against Human and Animal Prions: a First Possible Biomarker for Prion Therapeutics. Molecular neurobiology. 2021. Online ahead of print
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MISC (139)：
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Patents (2)：
  • コンフォメーション病医薬組成物
  • 異常型プリオン蛋白質の濃縮方法、および除去方法
Books (2)：
  • Prions - Food and Drug Safety
    Springer 2005
  • 脳科学研究の現状と課題
    じほう社 2003
Lectures and oral presentations  (134)：
  • Our Quest for Anti-prion Compounds 2022.
    (Asian Pacific Prion Symposium 2022.)
  • Structure-Activity relationship of curcumin-related compounds in ScN2a and N167.
    (Asian Pacific Prion Symposium 2022.)
  • Characterization of the actions of CRANAD on two prion strains and PrP-amyloid.
    (第59回ペプチド討論会)
  • フェロトーシス阻害剤による異常型プリオンタンパク質蓄積抑制機構の解明
    (第44回日本分子生物学会年会)
  • Photoreaction-induced SDS-resistant PrPSc/res oligomer formation.
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Professional career (1)：
  • 医学博士
Committee career (4)：
  • 2011/07 - 現在 Asian Pacific Society of Prion Research 理事
  • 2014/04 - 2018/03 食品安全委員会 プリオン専門調査会 専門委員
  • 2015/09 - 2017/10 Asian Pacific Society of Prion Research 理事長
  • 2005/01 - 2013/01 生物由来製品感染等被害判定調査会 薬事・食品衛生審議会専門委員
Association Membership(s) (1)：
Asian Pacific Society of Prion Research
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