OKUYAMA Ryuhei

2016 - 2019 Investigation of personalized medicine for melanoma and mechanism of drug resistance using circulating tumor cells.

2015 - 2018 Education for clinical researchers from a standpoint of conducting clinical trials for new drug application.

2015 - 2017 Clinical appearance of melanoma associated with the gene mutation for therapeutic target

2014 - 2017 Gene analysis in melanoma patients using circulating tumor DNA

2014 - 2017 Analysis of Notch signal pathway in epidermal regeneration and its application to therapy

2013 - 2016 Notch signaing promotes proliferation and migration of melanoma.

2013 - 2016 Analysis of role of aryl hydrocarbon receptor for pathophysiology of atopic dermatitis

2013 - 2016 the pathogenic mechanisms of EGFR inhibitor-induced rash and establishment of system for constructing medical treatment

2011 - 2013 Gene analysis in circulating melanoma cells isolated using novel monoclonal antibodies

2011 - 2013 Transcription factors Runx regulates differentiation and proliferation of keratinocyte

2008 - 2010 Regulation mechanism in keratinocyte growth and differentiation by p53 homologue p51/p63 and Maf

2006 - 2007 Development of animal models for cutaneous eosinophilic inflammation and analysis of its regulatory mechanisms

2005 - 2006 Differentiation disturbance in keratinocytes lacking the epidermal fatty acid binding protein gene (E-FABP) which is overexpressed in psoriatic lesions.

2005 - 2006 p53 homologue, p51/p63, controls keratinocyte proliferation/differentiation due to Notch activity

2003 - 2004 p53 homolog, p51/p63, maintains keratinocytes under undifferentiated state through suppression of Notch activity.

2002 - 2003 DNA microarrayを用いた皮膚線維芽細胞の亜集団の証明

2002 - 2003 Establishment of tretments for patients with atopic dermatitis based on the immunological background

2001 - 2002 Notchシグナル系による表皮細胞の増殖分化の調節と異常による皮膚疾患の発生