Rchr
J-GLOBAL ID:200901016371476131
Update date: Apr. 19, 2024
Kamada Haruhiko
カマダ ハルヒコ | Kamada Haruhiko
Affiliation and department:
Job title:
Project Leader
Other affiliations (4):
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National Institutes of Biomedical Innovation, Health and Nutrition
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Kyoto University
Graduate School of Pharmaceutical Sciences
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Osaka University
Graduate School of Pharmaceutical Sciences
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Osaka University
Homepage URL (1):
http://www.nibiohn.go.jp/bio-r/index.htm
Research field (9):
Tumor diagnostics and therapeutics
, Other
, Clinical pharmacy
, Hematology and oncology
, Urology
, Structural biochemistry
, Pathobiochemistry
, Pharmaceuticals - chemistry and drug development
, Molecular biology
Research keywords (16):
ファージ表面提示法
, 炎症
, 腫瘍壊死因子
, 血管内皮細胞
, プロテオーム
, 疾患関連タンパク質
, 炎症性メディエーター
, 炎症性たんぱく質
, バイオマーカー
, 乳がん
, 抗体
, プロテオミクス
, 血液学(血栓止血)
, 分子病態学
, Hematology(thrombosis and hemostasis)
, molecular pathobiology
Research theme for competitive and other funds (37):
- 2022 - 2025 Development of antibody design optimized for active targeting
- 2022 - 2024 <混ぜる>抗体工学 ~二重特異性抗体の効率的な創出法の開発~
- 2021 - 2024 機能性食品成分の腸管における標的分子の同定と腸内細菌叢への作用の解析
- 2019 - 2022 Development of molecular targeted drug using high-resolution epitope mapping: a novel therapeutic strategy for intraocular fibrotic scarring
- 2018 - 2021 Development of technology to search for novel antibody targets by proteomics specialized on the surface of circulating tumor cells
- 2018 - 2021 Study of the mechanism of functional food ingredients through the control of intestinal signals
- 2018 - 2020 Design of metamorphosis antibody molecule for cancer treatment and diagnosis
- 2014 - 2019 Development of a new diagnostic method for heart failure in collaboration with drug engineers
- 2016 - 2018 A new drug development for accelerating bone and/or cartilage formation by RANK-like peptide
- 2016 - 2018 A trimeric structural fusion of an antagonistic tumor necrosis factor-alpha mutant enhances molecular stability
- 2015 - 2017 Development of new purification method of extracellular vesicles for cancer diagnostics
- 2014 - 2017 Functional analysis of a novel breast cancer related protein: EphA10 for development of anti-EphA10 antibody drugs in refractory breast cancer cases
- 2015 - 2017 がんの早期診断に向けた分泌膜小胞の新規精製法の開発
- 2013 - 2016 Elucidation of nuclear import mechanism of argonaute 2 for efficient knockdown of nuclear-localizing non-coding RNA
- 2014 - 2016 腫瘍血管特異的分子BST2およびROBO4に対する新規バイオ医薬の開発
- 2012 - 2015 Drug target discovery for autoimmune diseases by using a technology creating functional mutant proteins
- 2012 - 2015 Creation of a new drug with a bispecific antibody against mesenchymal tissue
- 2012 - 2014 Molecular-based analysis of organ construction using proteomic analyis
- 2011 - 2012 Search for metastasis-related proteins in colorectal cancer by proteome analysis
- 2011 - 2011 Creation of functional mutant interferon-alpha for increase of bioactivity and decease of side-effects
- 2009 - 2010 Development of discovering technology to quantify the biomarker for minimally invasive diagnostics.
- 2008 - 2009 Development of functional mutant protein with antagonistic activity as an anti-inflammatory drug
- 2008 - 2009 An organelle targeting system as a next generation technology for drug development
- 2006 - 2007 がんに対するTNF療法の最適化を目指した基盤技術の開発
- 2006 - 2006 疾患関連蛋白質に対する網羅的一本鎖抗体ライブラリの作製と応用
- 2005 - 2005 分子進化戦略を用いた安全かつ有効な抗腫瘍サイトカインの創製とそのDDS
- 2004 - 2005 血管病変の形成に及ぼすC反応性蛋白質の分子細胞機構の解明
- 2004 - 2005 Effect of protein C inhibitor on renal cell carcinogenesis and on tumor invasion, growth and metastasis
- 2004 - 2004 多機能SERPIN,プロテインCインヒビターによる癌細胞の浸潤・転移制御機構
- 2002 - 2003 細胞マイクロレオロジー測定装置を用いた静脈性血栓症の新規診断システムの開発
- 2002 - 2003 Molecular pathobiological studies on the multi-functional SERPIN, protein C inhibitor-dependent diseases
- 2002 - 2002 細胞膜プロテアーゼ受容体の活性化を介する感染宿主応答としての組織障害機構
- 2000 - 2002 Development of high sensitive assay method to detect tissue specific regeneration markers -Protein chip -ELISA specific for liver regeneration
- 2000 - 2001 Structure-function relationship of the endothelial cell membrane receptors playing in the anti-thrombotic properties.
- 2000 - 2000 癌細胞の浸潤・転移の制御調節に関わる血液凝固関連因子の分子細胞学的研究
- 1999 - 1999 癌治療におけるハイブリッド化医薬品の分子設計
- Mechanisms of blood flow decrease
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Papers (162):
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Yoji Tsugawa, Kentaro Furukawa, Tomoko Ise, Masahiro Takayama, Takeshi Ota, Takayuki Kuroda, Shinya Shano, Takashi Hashimoto, Haruyo Konishi, Takeshi Ishihara, et al. Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo. 2024
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Masaki Inoue, Yuta Tsuji, Reira Ueno, Daisuke Miyamoto, Keisuke Tanaka, Yuka Moriyasu, Saya Shibata, Mei Okuda, Daisuke Ando, Yasuhiro Abe, et al. Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells. Scientific reports. 2023. 13. 1. 13762-13762
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Kentaro Nishiyama, Hiroki Akiba, Satoshi Nagata, Kouhei Tsumoto, Haruhiko Kamada, Hiroaki Ohno. A Proximity-Induced Fluorogenic Reaction Triggered by Antibody-Antigen Interactions with Adjacent Epitopes. Angewandte Chemie International Edition. 2023. 62. 30
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Kensuke Suzuki, Masaki Tajima, Yosuke Tokumaru, Yuya Oshiro, Satoshi Nagata, Haruhiko Kamada, Miho Kihara, Kohei Nakano, Tasuku Honjo, Akio Ohta. Anti-PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases. Science immunology. 2023. 8. 79. eadd4947
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Hiroki Akiba, Junso Fujita, Tomoko Ise, Kentaro Nishiyama, Tomoko Miyata, Takayuki Kato, Keiichi Namba, Hiroaki Ohno, Haruhiko Kamada, Satoshi Nagata, et al. Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection. 2022
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MISC (186):
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Tomokazu Yamaguchi, Midori Hoshizaki, Takafumi Minato, Satoru Nirasawa, Masamitsu Asaka, Mayumi Niiyama, Jianbo An, Daichi Utsumi, Satoshi Nagata, Haruhiko Kamada, et al. Therapeutic effects of angiotensin converting enzyme 2 (ACE2) enzyme activity on acute lung injury in COVID-19. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 2-O
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Utsumi Daichi, Masamitsu Asaka, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, Yoshihiro Kawaoka, Keiji Kuba, Yasuhiro Yasutomi. Establishment of SARS-CoV-2 respiratory tract infection model in CAG promoter-driven hACE2 transgenic mice. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 2-P
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田中佑弥, 谷奥有里花, 阿曽古都美, 中山泰亮, 鎌田春彦, 山口卓男, 小比賀聡. Synthesis and evaluation of lipid-modified antisense oligonucleotides. 日本薬学会年会要旨集(Web). 2021. 141st
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Tomokazu Yamaguchi, Takafumi Minato, Midori Hoshizaki, Masamitsu Asaka, Satoru Nirasawa, Mayumi Niiyama, Masaki Imai, Saori Takahashi, Daichi Utsumi, Jianbo An, et al. Suppression of SARS-CoV-2-induced lung injury by ACE2-like carboxypeptidase B38-CAP in COVID-19 mouse model. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 2-P2
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東阪和馬, 東阪和馬, 大須賀絵理, 笠原淳平, 豊田麻人, 尾花理徳, 鎌田春彦, 前田真貴子, 長野一也, 藤尾慈, et al. 心分泌蛋白質に着目した心不全に対する新規バイオマーカー探索. 日本薬学会年会要旨集(CD-ROM). 2018. 138th. 4. ROMBUNNO.27G-pm06-61
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Books (1):
Education (4):
- - 2000 Osaka University
- - 2000 Osaka University Graduate School, Division of Pharmaceutical Sciences
- - 1995 Osaka University School of Pharmaceutical Sciences
- - 1995 Osaka University Faculty of Pharmaceutical Science
Professional career (1):
Work history (9):
- 2016 - 現在 National Institutes of Biomedical Innovation, Health and Nutrition CDDR Project Leader
- 2010 - 2016 National Institutes of Biomedical Innovation, Health and Nutrition
- 2005 - 2010 National Institutes of Biomedical Innovation, Health and Nutrition
- 2007 - 2008 Swiss Federal Institute of Technology Guest Researcher
- 2004 - 2005 国立医薬品食品衛生研究所 大阪支所 主任研究官
- 2000 - 2004 Mie University Faculty of Medicine
- 1999 - 2000 日本学術振興会 特別研究員(がん)
- 1999 - 2000 Japan Society for the Promotion of Science,
- 2000 - Mie University, Research Assistant
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Committee career (1):
- 2003 - 日本血栓止血学会 小委員会 動物モデル
Awards (4):
- 2019/02 - Osaka Bio Headquater Grand prize Functional antibody creation technology for development of antibody drug
- 2011/07 - International Society of Thrombosis and Hemostasis Asian-Pacific Scholarship Creation of TNFR1-selective mutant TNF with antagonistic activity.
- 2006 - 武田科学振興財団 薬学系研究奨励
- 1998 - 日本薬剤学会優秀論文賞
Association Membership(s) (7):
THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
, 日本DDS学会
, 日本プロテオーム機構
, 日本薬学会
, 日本生化学会
, 日本血栓止血学会
, 日本癌学会
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