Dohgu Shinya

ドウグシンヤ | Dohgu Shinya

Affiliation and department：

Research field (2)： Pharmacology , Clinical pharmacy

Research keywords (3)： Neurovascular Unit , Pericyte , Blood-Brain Barrier

Research theme for competitive and other funds (15)：

2023 - 2026 Chronotherapeutic strategy for Parkinson's disease by intranasal administration of human iPS-derived brain pericytes
2021 - 2025 Prevention of impaired cognitive function by food factors
2021 - 2024 病変型脳ペリサイトのαシヌクレイン処理能障害による頭部外傷後のパーキンソン病発症
2019 - 2022 Involvement of activated brain pericytes induced by inflammatory bowel disease in the increased aggregation of alpha-synuclein in the brain.
2016 - 2019 The brain pericytes-induced blood-brain barrier dysfunction and the central adverse effects in the chronic obstructive pulmonary disease

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Papers (72)：

Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yuki Goto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu. Senescence in brain pericytes attenuates blood-brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains. Biochemical and biophysical research communications. 2023. 645. 154-163
Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu. Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice. PloS one. 2023. 18. 2. e0281946
Koshun Inada, Mitsuhisa Koga, Ayano Yamada, Shinya Dohgu, Atsushi Yamauchi. Moxifloxacin induces aortic aneurysm and dissection by increasing osteopontin in mice. Biochemical and biophysical research communications. 2022. 629. 1-5
Taira Matsuo, Rie Komori, Minami Nakatani, Shiori Ochi, Aya Yokota-Nakatsuma, Junichi Matsumoto, Fuyuko Takata, Shinya Dohgu, Yasuhiro Ishihara, Kouichi Itoh. Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice. International journal of molecular sciences. 2022. 23. 14
Takata F, Nakagawa S, Matsumoto J, Dohgu S. Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction. Front Cell Neurosci. 2021. 15. 661838

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MISC (27)：

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Patents (3)：

血液脳関門透過性ペプチド
血液脳関門障害症候群治療薬
血液脳関門障害症候群治療薬

Books (1)：

Birbrair A. (eds) Biology of Pericytes - Recent Advances. Stem Cell Biology and Regenerative Medicine, vol 68.
Humana, Cham 2021

Education (1)：

2001 - 2004 Kyushu University Graduate School of Pharmaceutical Sciences Medico-Pharmaceutical Sciences

Professional career (2)：

博士(薬学) (九州大学)
Ph.D. (Kyushu University)

Work history (5)：

2020/10/01 - Fukuoka University Faculty of Pharmaceutical Sciences Professor
2008/04/01 - 2020/09/30 Fukuoka University Faculty of Pharmaceutical Sciences Associate Professor
2005/07/01 - 2008/03/31 Saint Louis University School of Medicine Postdoctoral Fellow
2005/10/01 - 2006/03/31 Fukuoka University Advanced Materials Institutes 研究員
2004/04/01 - 2005/09/30 Fukuoka University Advanced Materials Institutes Postdoctoral Fellow

Association Membership(s) (3)：

日本薬理学会 , 日本薬学会 , 日本薬物動態学会

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