Rchr
J-GLOBAL ID:200901016783653330   Update date: Jan. 31, 2024

Hosoi Yoshio

ホソイ ヨシオ | Hosoi Yoshio
Research field  (1): Radiology
Research keywords  (7): 放射線腫瘍生物学 ,  低酸素・低栄養 ,  DNA-PK ,  ATM ,  DNA2重鎖切断修復 ,  放射線感受性 ,  放射線
Research theme for competitive and other funds  (23):
  • 2020 - 2024 Muse細胞を用いた正常組織の放射線障害の治療と幹細胞の放射線抵抗性の機序解明
  • 2014 - 2018 Study on effects of modified mTOR activities under hypoxia and nutrient starvation on radiation sensitivity of cancer cells.
  • 2014 - 2017 NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells
  • 2011 - 2013 Radiosensitization of radioresistant cancer stem cells by inhibition of ATM
  • 2008 - 2010 COX-2・EGF受容体・DNA-PK・ATMのクロストーク解析による放射線増感
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Papers (91):
  • Yusuke Urushihara, Takuma Hashimoto, Yohei Fujishima, Yoshio Hosoi. AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation. International Journal of Molecular Sciences. 2023. 24. 16. 12828-12828
  • Masaki Fujisawa, Yoshihiro Haga, Masahiro Sota, Mitsuya Abe, Yuji Kaga, Yohei Inaba, Masatoshi Suzuki, Taiichiro Meguro, Yoshio Hosoi, Koichi Chida. Evaluation of Lens Doses among Medical Staff Involved in Nuclear Medicine: Current Eye Radiation Exposure among Nuclear-Medicine Staff. Applied Sciences. 2023. 13. 16. 9182-9182
  • Hidetoshi Satoh, Shintaro Ochi, Kosuke Mizuno, Yutaka Saga, Shohei Ujita, Miyu Toyoda, Yuichi Nishiyama, Kasumi Tada, Yosuke Matsushita, Yuichi Deguchi, et al. Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors. Bioorganic & Medicinal Chemistry. 2022. 67. 116764-116764
  • Takuma Hashimoto, Yusuke Urushihara, Yasuhiko Murata, Yohei Fujishima, Yoshio Hosoi. AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines. Biochemical and biophysical research communications. 2022. 590. 82-88
  • Akinori Morita, Shintaro Ochi, Hidetoshi Satoh, Shohei Ujita, Yosuke Matsushita, Kasumi Tada, Mihiro Toyoda, Yuichi Nishiyama, Kosuke Mizuno, Yuichi Deguchi, et al. A Novel RNA Synthesis Inhibitor, STK160830, Has Negligible DNA-Intercalating Activity for Triggering A p53 Response, and Can Inhibit p53-Dependent Apoptosis. Life (Basel, Switzerland). 2021. 11. 10
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MISC (26):
  • 村田 泰彦, 橋本 拓磨, 志賀 壮一郎, 武田 一也, 細井 義夫. 低酸素および低栄養状態のヒト線維芽細胞におけるAMPKの活性化は放射線抵抗性を増加させる. 日本放射線影響学会大会講演要旨集. 2017. 60回. 129-129
  • A. K. Putra, K. Tanimoto, E. Hiyama, M. Nishiyama, Y. Hosoi, K. Hiyama. EXPLORATION OF THE GENES ASSOCIATED WITH CELLULAR IMMORTALIZATION IN LUNG CANCER. RESPIROLOGY. 2011. 16. 151-151
  • 榎本 敦, 木戸 直樹, 細井 義夫. PI-3K阻害剤WortmanninによるSerine/Threonine Kinase 38(STK38)の阻害. 放射線生物研究. 2008. 43. 2. 203-209
  • ENOMOTO ATSUSHI, KIDO NAOKI, MORITA AKINORI, SUZUKI TAKAHIKO, MATSUMOTO YOSHIHISA, HOSOI YOSHIO, MIYAGAWA KIYOSHI. Regulation of MAPKKK of JNK cascade by a novel protein kinase. 2006. 25. 1. 61-61
  • 森田 明典, 鈴木 紀夫, 細井 義夫. アポトーシスシグナリングと放射線防護. 放射線生物研究. 2005. 40. 4. 360-384
more...
Professional career (1):
  • MD, PhD (Tohoku University)
Work history (1):
  • 2013/04 - 現在 Tohoku University International Research Institute of Disaster Science
Association Membership(s) (5):
放射線腫瘍学会生物部会 ,  Japanese Association for Radiation Accident/Disaster Medicine ,  THE JAPANESE RADIATION RESEARCH SOCIETY ,  JAPANESE SOCIETY FOR RADIATION ONCOLOGY ,  JAPAN RADIOLOGICAL SOCIETY
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