Rchr
J-GLOBAL ID：200901016846374045   Update date: Jan. 31, 2024

Matsumoto Yoshihisa

マツモト ヨシヒサ | Matsumoto Yoshihisa
Affiliation and department：
Tokyo Institute of Technology Institute of Innovative Research

About Tokyo Institute of Technology Institute of Innovative Research


Job title： Associate Professor
Research field  (4)： Radiology ,  Molecular biology ,  Environmental effects of chemicals ,  Environmental effects of radiation
Research keywords  (20)： Antibody ,  Protein Phosphorylation ,  Cancer Therapy ,  Hyperthermia ,  Radiation Effect ,  Radiation Response ,  Radiosensitivity ,  DNA Repair ,  DNA Double-strand Break ,  DNA-dependent Protein Kinase ,  抗体 ,  タンパク質リン酸化 ,  がん治療 ,  温熱療法 ,  放射線影響 ,  放射線応答 ,  放射線感受性 ,  DNA修復 ,  DNA二重鎖切断 ,  DNA依存性プロテインキナーゼ
Research theme for competitive and other funds  (43)：
  • 2022 - 2027 Development of ultra-sensitive high-throughput single cell elemental analysis system and creation of single cell metallomics
  • 2022 - 2025 Development of a high-sensitive, high-throughput single-cell elemental analysis system directly connected to a flow cytometer
  • 2020 - 2024 The new strategy for radioresistance in cancer associated with p53 mutation using targeted alpha therapy
  • 2021 - 2023 Paradigm shift in mutation research brought by next generation sequencing: from specific locus test to whole genome analysis
  • 2020 - 2023 Biological Significance of DNA-PK in the Orchestration of Cellular Response to DNA Double-strand Breaks
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Papers (117)：
  • Kai Nishikubo, Maho Hasegawa, Yudai Izumi, Kentaro Fujii, Koichi Matsuo, Yoshihisa Matsumoto, Akinari Yokoya. Structural study of wild-type and phospho-mimic XRCC4 dimer and multimer proteins using circular dichroism spectroscopy. International journal of radiation biology. 2023. 1-36
  • Rikiya Imamura, Mizuki Saito, Mikio Shimada, Junya Kobayashi, Masamichi Ishiai, Yoshihisa Matsumoto. APTX acts in DNA double-strand break repair in a manner distinct from XRCC4. Journal of Radiation Research. 2023. 64. 3. 485-495
  • Mikio Shimada, Takumi Tokumiya, Tomoko Miyake, Kaima Tsukada, Norie Kanzaki, Hiromi Yanagihara, Junya Kobayashi, Yoshihisa Matsumoto. Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells. Journal of radiation research. 2023
  • Hisayo Tsuchiya, Mikio Shimada, Kaima Tsukada, Qingmei Meng, Junya Kobayashi, Yoshihisa Matsumoto. THE ROLE OF DNA DOUBLE-STRAND BREAK REPAIR THROUGH NON-HOMOLOGOUS END JOINING IN THE DOSE-RATE EFFECT IN TERMS OF CLONOGENIC ABILITY. Radiation Protection Dosimetry. 2022. 198. 13-15. 990-997
  • Masanori Someya, Takaaki Tsuchiya, Yuki Fukushima, Tomokazu Hasegawa, Masakazu Hori, Mio Kitagawa, Toshio Gocho, Shoh Mafune, Yutaro Ikeuchi, Yoshihiko Hirohashi, et al. Prediction of treatment response from the microenvironment of tumor immunity in cervical cancer patients treated with chemoradiotherapy. Medical molecular morphology. 2021. 54. 3. 245-252
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MISC (59)：
  • 長谷川真保, 長谷川真保, 西久保開, 西久保開, 藤原悟, 松尾龍人, 松本義久, 横谷明徳, 横谷明徳. DNA修復タンパク質XRCC4及びその変異体タンパク質のSAXS構造解析. KEK Progress Report (Web). 2021. 2021-4
  • 吉田真己, 吉田真優子, 末永祐磨, 沖野晃俊, 青木元秀, 梅村知也, 岩井貴弘, 松本義久, 川田善正, 千葉光一. Development of infrared desolvation system for trace elements analysis in single human cell. 生体医歯工学共同研究拠点成果報告書. 2020. 2019
  • 西久保開, 西久保開, 長谷川真保, 長谷川真保, 泉雄大, 藤井健太郎, 松尾光一, 松本義久, 横谷明徳, 横谷明徳. VUV-CDで見えてきたリン酸化によるXRCC4会合体の構造変化解析. 日本放射光学会年会・放射光科学合同シンポジウム(Web). 2020. 33rd
  • 吉田真己, 吉田真優子, 末永祐磨, 沖野晃俊, 青木元秀, 梅村知也, 岩井貴弘, 松本義久, 川田善正, 千葉光一. Development of infrared desolvation system for trace elements analysis in single human cell. 生体医歯工学共同研究拠点成果報告会. 2020. 2019
  • 吉田真己, 吉田真優子, 末永祐磨, 青木元秀, 岩井貴弘, 松本義久, 梅村知也, 川田善正, 千葉光一, 沖野晃俊. ハイスループット細胞分析のための赤外線ドロプレット脱溶媒装置の開発. 分析化学討論会講演要旨集(Web). 2020. 80th
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Books (10)：
  • 原子力年鑑2020
    日刊工業新聞社 2019
  • 放射線生物学の事典
    朝倉書店 2019
  • Recent Trends and Advances in Environmental Health
    Nova Science Publishers 2019
  • 人体のメカニズムから学ぶ 放射線生物学
    メジカルビュー社 2017
  • 新版 放射線医科学-生体と放射線•電磁波・超音波-
    医療科学社 2016
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Lectures and oral presentations  (184)：
  • Basic Mechanisms for DNA Double-strand Break Repair
    (Second International School on Radiation Research (ISRR-2020) 2020)
  • Analysis of mechanism of DNA repair machinery and cell death in induced pluripotent stem cells
    (International Congress of Radiation Resarch 2019 2019)
  • Phosphorylation of XRCC4 by DNA-dependent protein kinase in DNA double-strand break repair through non-homologous end joining
    (International Congress of Radiation Resarch 2019 2019)
  • Functional Analysis of Disease-associated XRCC4 Mutations and its implication in DNA Repair and Immune System
    (International Congress of Radiation Resarch 2019 2019)
  • BLM遺伝子が調節するDNA損傷修復機構
    (第56回アイソトープ・放射線研究発表会 2019)
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Works (16)：
  • DNA二重鎖切断の認識・修復の分子機構に基づく放射線感受性予測・制御の新戦略体系(文部科学省科学研究費補助金 若手研究(A))
    2005 - 2007
  • 長期的視点に立ったアジア地域の放射線科学研究基盤強化のための若手研究者の連携(日本学術振興会科学研究費補助金 基盤研究(C))
    2005 - 2005
  • Joinasome:DNA二重鎖切断修復に関わる超高次複合体の解明(日本学術振興会科学研究費補助金 萌芽研究)
    2005 - 2005
  • DNA二重鎖切断センサーDNA-PKを指標とした新しい放射線感受性・癌罹患性予測法の開発
    2004 - 2004
  • DNA二重鎖切断修復酵素を指標とした放射線感受性予測システムの可能性(がん研究振興財団研究奨励助成)
    2004 - 2004
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Education (5)：
  • 1995 - 1998 University of Tokyo Graduate School of Science Department of Biochemistry and Biophysics, Ph.D Course
  • - 1998 The University of Tokyo Graduate School, Division of Science Department of Biochemstry and Biophysics
  • 1993 - 1995 University of Tokyo Graduate School of Science Department of Biochemistry and Biophysics, Master Course
  • 1991 - 1993 University of Tokyo School of Science Department of Biochemistry and Biophysics
  • 1989 - 1991 University of Tokyo College of Arts and Sciences
Professional career (2)：
  • Doctor of Science (The University of Tokyo)
  • Master of Science (The University of Tokyo)
Work history (10)：
  • 2016/04 - 現在 Tokyo Institute of Technology Institute of Innovative Research, Laboratory for Advanced Nuclear Energy Associate Professor
  • 2007/04 - 2016/03 Tokyo Institute of Technology Research Laboratory for Nuclear Reactor Associate Professor
  • 2006/12 - 2007/03 Tokyo Institute of Technology Research Laboratory for Nuclear Reactor Associate Professor
  • 2003 - 2006 :The University of Tokyo Graduate School of Medicine, Center for Disease Biology and Integrative Medicine Assistant Professor
  • 2003 - 2006 University of Tokyo Graduate School of Medicine, Center for Disease Biology and Integrative Medicine, Department of Radiation Research Associate Professor
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Awards (7)：
  • 2017/07 - International Association for Sensitization of Cancer Treatment Excellent Presentation Award in 23rd Research Workshop Radiosensitivity of Shin-Godzilla
  • 2014/11 - Japan Society for the Promotion of Science Commendation of Excellent Reviewer
  • 2014/07 - Japanese Society for Radiation Oncology, Japanese Group of Radiation Biology Japanese Group of Radiation Biology Award
  • 2012/11 - Japan Society for the Promotion of Science Commendation of Excellent Reviewer
  • 2011/02 - Basic Strategic Research Initiative in Nuclear Power Young Investigator Award in Basic Strategic Research Initiative in Nuclear Power Study on the initial stage of the recognition and repair of DNA double-strand breaks
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Association Membership(s) (9)：
Molecular Biology Society of Japan ,  Japan Cancer Association ,  Japan Association for Radiation Research ,  日本分子生物学会 ,  日本医学放射線学会生物部会 ,  日本癌学会 ,  日本放射線影響学会 ,  ATOMIC ENERGY SOCIETY OF JAPAN ,  International Association for Sensitization of Cancer Treatment
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