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J-GLOBAL ID：200901017050680795   Update date: Apr. 14, 2024

Kanoh Naoki

カノウ ナオキ | Kanoh Naoki
Affiliation and department：
Hoshi University

About Hoshi University


Job title： Professor
Homepage URL  (2)： https://polaris.hoshi.ac.jp/kyoshitsu/seitaiyuki/ ,  https://polaris.hoshi.ac.jp/kyoshitsu/seitaiyuki/index-e.html
Research field  (5)： Biochemistry ,  Synthetic organic chemistry ,  Chemical biology ,  Pharmaceuticals - chemistry and drug development ,  Molecular biochemistry
Research keywords  (12)： synthetic organic chemistry ,  bioactive small molecules ,  Induced pluripotent small molecules ,  polyene macrolactam ,  Proteolysis-targeting chimera ,  small molecule microarray ,  cytochrome P450 ,  chemical proteomics ,  probe synthesis ,  mode-of-action analysis ,  structure-activity relationship ,  bioactive natural products
Research theme for competitive and other funds  (16)：
  • 2023 - 2026 ポリエンマクロラクタム型人工多能性幹分子の概念拡大と新規分子創製
  • 2022 - 2024 PROTAC特有の標的タンパク質分解誘導機構を探索する分子プローブ群の創製と活用
  • 2022 - 2024 Generation of hybrid molecules that facilitate and optimize target protein degradation
  • 2019 - 2022 Synthesis and structural diversification of induced pluripotent stem molecules based on polyene macrolactam natural products
  • 2018 - 2020 Chemical signaling analysis of membrane-binding natural products using synthetic probes
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Papers (114)：
  • Yuki Tateishi, Ryo Sato, Shingo Komatsu, Masatsugu Noguchi, Shota Nagasawa, Yusuke Sasano, Naoki Kanoh, Yoshiharu Iwabuchi. Asymmetric Total Synthesis of Cytotrienin A: Late-stage Installation of C11 Side Chain onto the Macrolactam Scaffold. Angewandte Chemie (International ed. in English). 2023. e202303140
  • Hiromasa Yokoe, Akiko Kiriyama, Miho Shimoda, Satoru Nakajima, Yuna Hashizume, Yuto Endo, Ryoko Iwamoto, Masayoshi Tsubuki, Naoki Kanoh. Cis-Selective Double Spirocyclization via Dearomatization and Isomerization under Thermodynamic Control. The Journal of Organic Chemistry. 2023
  • Naoki Kanoh. Naturally Occurring Polyene Macrolactams as Pluripotent Stem Molecules: Their Chemistry and Biology, and Efforts Toward the Creation of Polyene Macrolactam-based Induced Pluripotent Small Molecules. J. Synth. Org. Chem., Jpn. 2022. 80. 9. 817-830
  • Yifan Huang, Hiromasa Yokoe, Ai Kaiho-Soma, Kazunori Takahashi, Yusuke Hirasawa, Hiroshi Morita, Fumiaki Ohtake, Naoki Kanoh. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation. Bioconjugate Chemistry. 2021. 33. 1. 142-151
  • Naoki Kanoh, Ryusei Terashima, Hiromichi Nishiyama, Yuta Terajima, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Hiroaki Saito, Syusuke Egoshi, Kosuke Dodo, et al. Design, Synthesis, and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C. The Journal of Organic Chemistry. 2021. 86. 23. 16249-16258
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MISC (251)：
  • 下田実穂, 横江弘雅, 横江弘雅, 中島諒, 叶直樹, 叶直樹. Development of cis-selective double spirocyclization via isomerization. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 三村匠太朗, 吉木美穂, 吉木美穂, 小林容直, 李智成, 小山栞, 横江弘雅, 横江弘雅, 叶直樹, 叶直樹. Facile synthesis of 3-enoyltetramic acid derivatives via three-component coupling. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 桐山明子, 横江弘雅, 横江弘雅, 下田実穂, 中島諒, 橋爪優奈, 遠藤雄斗, 岩本涼子, 津吹政可, 津吹政可, et al. Cis-selective synthesis of diazadispirocycles via dearomatization. 日本薬学会年会要旨集(Web). 2022. 142nd
  • 吉木美穂, 吉木美穂, 三村匠太朗, 小林容直, 李智成, 小山栞, 岩渕好治, 横江弘雅, 横江弘雅, 叶直樹, et al. 三成分連結による3-エノイルテトラミンの酸誘導体の簡便合成法の開発(I). 日本薬学会関東支部大会講演要旨集. 2022. 66th (CD-ROM)
  • 小林容直, 三村匠太朗, 吉木美穂, 吉木美穂, 李智成, 小山栞, 岩渕好治, 横江弘雅, 横江弘雅, 叶直樹, et al. 三成分連結による3-エノイルテトラミン酸誘導体の簡便合成法の開発(2). 日本薬学会関東支部大会講演要旨集. 2022. 66th (CD-ROM)
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Patents (3)：
  • 固相単体への低分子化合物の固定化法
  • 相互作用観察法
  • 錯体化合物、炭素炭素三重結合を有する化合物の製造方法等
Education (2)：
  • 1992 - 1997 Hokkaido University Graduate School of Science Division of Chemistry
  • 1988 - 1992 Hokkaido University Faculty of Science Department of Chemistry
Professional career (1)：
  • Ph.D. (Hokkaido University)
Work history (8)：
  • 2020/04 - 現在 Hoshi University Institute of Medicinal Chemistry Director
  • 2019/04 - 現在 Hoshi University Institute of Medicinal Chemistry Professor
  • 2007/04 - 2019/03 Tohoku University Graduate School of Pharmaceutical Sciences Associate Professor
  • 2006/10 - 2007/03 Tohoku University Graduate School of Pharmaceutical Sciences Associate Professor
  • 2001/04 - 2006/09 RIKEN Antibiotics Laboratory Research Scientist(2001-2006), Senior Research Scientist(2007)
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Committee career (7)：
  • 2015 - 現在 日本ケミカルバイオロジー学会 世話人
  • 2007 - 現在 フロンティア生命化学研究会 運営委員、理事
  • 2010 - 2022 新規素材探索研究会 幹事
  • 2007 - 2015 天然物化学談話会 世話人
  • 2011 - 2013 公益社団法人 日本薬学会 「ファルマシア」誌トピックス専門小委員
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Awards (5)：
  • 2015/10 - 14th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds Elsevier Best Poster Prize
  • 2009/02 - 有機合成化学協会 有機合成化学協会奨励賞
  • 2006/03 - 第86回日本化学会春季年会 若い世代の特別講演
  • 2004/02 - 有機合成化学協会 有機合成化学協会第一製薬研究企画賞
  • 2003/10 - 天然物討論会 第45回天然有機化合物討論会奨励賞
Association Membership(s) (9)：
日本ケミカルバイオロジー学会 ,  Forum on Biomolecular Chemistry ,  The Pharmaceutical Society of Japan ,  The Japanese Association for Molecular Target Therapy of Cancer ,  Japanese Society for Bioscience, Biotechnolotgy, and Agrochemistry ,  American Chemical Society ,  The Society of Synthetic Organic Chemistry, Japan ,  Chemical Socierty of Japan ,  The Japanese Cancer Association
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