Kuboniwa Masae

2021 - 2024 Development of a Novel Evaluation System Useful for Determining Periodontitis Grading Classification

2019 - 2022 Detection of adult lifestyle-related presymptomatic disease by a dynamic network marker derived from oral specimens

2019 - 2022 Analysis of genes responsible for the gingival epithelial barrier leading to the development of periodontal disease

2019 - 2022 An informatics approach to clarify the multiple influence of oral status, microbiota and nutrition on systemic conditions

2018 - 2022 Molecular basis of colonization of periodontal pathogen into periodontal tissues

2018 - 2021 Development of high-precision periodontal health examination using saliva

2016 - 2019 Association of the onset of refractory periapical periodontitis with oral microbiota

2015 - 2019 The role of complex infection with oral resident microbiota: epidemiological elucidation for new hypotheses of oral-systemic relations

2015 - 2018 Development of a novel method to prevent an ecological shift in oral polymicrobial biofilms by using bacteriophage therapy.

2015 - 2018 Development of rheumatoid arthritis prevention method targeting P. gingivalis

2014 - 2018 Establishment of the periodontitis onset risk rating system for the realization of predictive dentistry

2015 - 2017 Development of a bacteriophage therapy against periodontopathic microbiome

2013 - 2017 Comprehensive multiomics analysis of mechanism of biofilm formation by oral normal baciterlal flora and periodontopathic bacteria

2012 - 2015 Study of new biomarkers for periodontal disease using Phosphoproteome

2012 - 2015 Obesity, chronic inflammation and gene-environment interaction: common pathological basis of oral and metabolic diseases

2012 - 2015 Elucidation of the functional mechanism underlying aspiration pneumonia in lethal influenza and its prevention

2012 - 2015 Molecular basis of phenotype alteration between planktonic and biofilm in Porphyromonas gingivalis

2012 - 2014 Molecular dissection of periodontal susceptibility for generation of predictive dentistry

2011 - 2014 Periodontal disease susceptibility evaluated on membrane traffic machinery

2010 - 2011 In vitro study on comparison of epigenetic alteration patterns between periodontitis and a particular type of cancer models

2009 - 2011 Relationship between tooth loss and risk factors for cancer

2008 - 2010 Role of multifunctional protein, GAPDH, associated with bacteria and human cells in infection by periodontopathic bacteria

2008 - 2010 Database on general health status and oral health behavior for improving supportive periodontal treatment

2008 - 2009 Proteomics of Porphyromonas gingivalis within a model oral microbial community

2007 - 2009 Molecular mechanism involved in the association of periodontal disease with pathology of metabolic syndrome

2007 - 2008 Elucidation of mechanism of enhanced innate salivary-IgA antibody to Thymus-independent antigen

2006 - 2007 Elucidation of molecular mechanism on periodontal bacterial adherence, invasion and signal transduction to human cell

2006 - 2007 Identification of Streptoooocus gordoniigenes involved in recruiting Porphyromonas gingivatiscens into a multispecies biofilm

2006 - 歯周病原性菌の感染が歯肉上皮細胞の細胞周期に及ぼす影響

2005 - 歯周病原性バイオフイルムの形成メカニズムに関する研究

2002 - 2003 Development of effective immunization by DNA vaccine against iron-acquisition protein of periodontopathic bacteria

2002 - 2003 細菌クオラムセンシングの歯肉縁下バイオフィルム形成に果たす役割の解析

2001 - 2002 Development of clinical diagnostic test and DNA vaccination based on genotypes of the periodontal pathogen

2001 - 2002 Development of a peptide inhibit oral bacteria related with senile pneumonia

2001 - 2002 歯周病原性菌のシステインプロテアーゼを標的としたDNAワクチンの開発

1999 - 2001 Biomolecular analysis on iron acquisition mechanism and pathogenicity of periodontopathic bacteria

2001 - Detection of periodontopathic bacteria by real-time PCR

1999 - 2000 歯周病原性菌の鉄獲得を制御するレプレッサー蛋白の遺伝子クローニングと機能解析

1996 - 1997 Analysis of structure and function of saliva protein receptor domains for periodontopathogen

1996 - 1996 ポルフィロモナスジンジバリスのヘモグロビン結合性蛋白質の精製と遺伝子クローニング

Study on Iron Uptake Mechanism of Periodontal Pathogen