2019 - 2020 Combined effects of space radiation and variable gravity
2017 - 2019 頭頸部がん微小環境におけるがん幹細胞のEMTを介した浸潤・転移機構の解明
2015 - 2019 Acute Effects of Space Radiation with Different Radiation Qualities and Dose-rates
2015 - 2019 宇宙からひも解く新たな生命制御機構の統合的理解
2016 - 2018 がん幹細胞を標的とした重粒子線および温熱治療の基礎的研究
2014 - 2016 Selection of DSBs repair pathways in heat-induced cell death mediated by BRCA2
2014 - 2016 Elucidation of cancer invasion / metastasis mechanism associated with abnormal glucose metabolism and activation of EMT signaling in head and neck cancer
2011 - 2015 放射線による細胞応答機構の解明
2011 - 2015 Elucidation of molecular mechanisms for radiation-induced cellular responses
2015 - Biological effect of space radiation
2011 - 2013 Elucidation of the cancer stem cell activation mechanism by EMT in invasion and metastasis of head and neck cancer
2011 - 2013 Elucidation of the suppression mechanism to activation of cancer stem cells by hyperthermia
2010 - 2012 Elucidation of the radio-sensitization mechanism by heat
2008 - 2010 Effect of mTOR inhibitors on radiation sensitivity of head and neck cancer cells
2008 - 2010 Analysis of cell nuclear dynamics in thermotolerance development
2006 - 2008 A study of the Heavy-ion beams medical treatment on the oral cancer
2006 - 2007 To clarify of the mechanism of thermotolerance
2006 - 2007 放射線誘導DSB認識タンパク質の挙動解明
2005 - 2007 Regulation of radiation-induced apoptosis targeting signal transduction factors
2004 - 2006 Low dose-rate effects and non-homologous end-joining repair pathway of double strand breaks
2004 - 2005 ハイパーサーミアによるヒストンH2AXのリン酸化機構の解明
2000 - 2004 分子シャペロンを併用した放射線・温熱癌治療法の基礎的研究
2002 - 2003 重粒子線特異的誘導新規p53非依存性アポトーシス関連遺伝子の探索
2000 - 2001 重粒子線と温熱との併用療法の基礎的研究
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Papers (183)：
Polina Malatesta, Konstantinos Kyriakidis, Megumi Hada, Hiroko Ikeda, Akihisa Takahashi, Premkumar Saganti, Alexandros Georgakilas, Ioannis Michalopoulos. Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity. Biomolecules. 2024
Takuya Adachi, Yukari Yoshida, Kei Shibuya, Ken Sato, Yuichi Yamazaki, Satoru Kakizaki, Toshio Uraoka, Akihisa Takahashi. Partial liver irradiation in rats induces the hypertrophy of non-irradiated liver lobes through hepatocyte proliferation. J Radiat Res. 2023. 64. 693-701
Anggraeini Puspitasari, Fabio Squarcio, Martina Quartieri, Cristina Totis, Timna Hitrec, Akihisa Takahashi, Yukari Yoshida, Kenji Hanamura, Tomoko Yako, Matteo Cerri, et al. Synthetic torpor protects rats from exposure to accelerated heavy ions. Scientific Reports. 2022. 12. 1. 16405-16405
Shenke Zhang, Takuya Adachi, Shengli Zhang, Yukari Yoshida, Akihisa Takahashi. A new type of simulated partial gravity apparatus for rats based on a pully-spring system. Front Cell Dev Biol . 2022. 10. 965656
Zhenlin Ju, Tamlyn Thomas, Yi-Jen Chiu, Sakuya Yamanouchi, Yukari Yoshida, Jun-ichi Abe, Akihisa Takahashi, Jing Wang, Keigi Fujiwara, Megumi Hada. Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector. International Journal of Molecular Sciences. 2022. 23. 6127
Jun Hirayama, Atsuhiko Hattori, Akihisa Takahashi, Yukihiro Furusawa, Yoshiaki Tabuchi, Masahiro Shibata, Aiko Nagamatsu, Sachiko Yano, Yusuke Maruyama, Hajime Matsubara, Toshio Sekiguchi, Nobuo Suzuki. Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure. Journal of Pineal Research. 2022
Akihisa Takahashi. Study for Managing Space Radiation Risk in Deep Space. 2021. 279. 6. 550-554
Afshin Beheshti, John McDonald, Megumi Hada, Akihisa Takahashi, Christopher E Mason, Maddalena Mognato. Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells. International Journal of Molecular Sciences. 2021
Anggraeini Puspitasari, Matteo Cerri, Akihisa Takahashi, Yukari Yoshida, Kenji Hanamura, Walter Tinganelli. Hibernation as a tool for radiation protection in space exploration. Life. 2021. 11. 54
Chromosome aberration induction by simulation environment of outer space, Moon and Mars
(2nd JSQMS meeting 2022)
Deep space and mitochondria
(JPW2022 2022)
FLASH carbon-ion irradiation~First report: construction of system and cultur ed cell experiments~
(2022)
Expression profile of cell cycle / aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity
(ASGSR 2022 2022)
The early proteomic responses of cultured mammalian cells exposed to simulated microgravity
(ASGSR 2022 2022)
2020/08 - Elsevier One of the Most Valued Reviewers from 2019 (LSSR)
2016 - Scientific Dream Award of The 6th International Society of Radiation Neurobiology Conference
2016 - The Prize of The Japanese Society for Biological Sciences in
2016 - Excellent Award of the 41st Japan Health & Research Institute
2015 - ICRR2015 Excellent Poster Award
2013 - 第1回日本放射線腫瘍学会 生物部会賞
2013 - 第1回関東ハイパーサーミア研究会 優秀発表賞
2010 - 日本ハイパーサーミア学会 優秀論文賞
2009 - Japanese Society of Thermal Medicine Abe Award
2009 - International Association for the Sensitization of Cancer Treatment Association Award
2008 - Young Investigator Award from Radiation Effects Association
2005 - 日本ハイパーサーミア学会 研究奨励賞
2005 - 中島佐一 学術研究奨励賞
2002 - 日本放射線影響学会 JRR表紙デザインコンテストグランプリ
2001 - Incentive Award from Japanese Association of Radiation Research Society
2000 - Young Investigator Award from International Association for the Sensitization of Cancer Treatment
1998 - Young Investigator Award from Japanese Association of Space Biology Science
1980 - 財団法人東京都体育協会 体育優良章
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Association Membership(s) (11)：
宇宙惑星居住科学連合
, Japanese Society of Space Radiation Research (JSSRR)
, International Association for the Sensitization of Cancer Treatment (IASCT)
, International Society of Radiation Neurobiology (ISRN)
, 関東ハイパーサーミア研究会
, Japanese Society of Thermal Medicine (JSTM)
, Japanese Association of Cancer Research (JACR)
, 日本宇宙生物学会
, 日本放射線腫瘍学会
, The Japan Radiation Research Society (JRRS)
, PTCOG Radiobiology Sub-committee
