Takahashi Ken

タカハシケン | Takahashi Ken

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://ken-takahashi.net/

Research field (6)： Physiology , Biomaterials , Biomedical engineering , Bio-, chemical, and soft-matter physics , Clinical pharmacy , Physiology

Research keywords (10)： organ on a chip , ischemia-reperfusion injury , myocardial infarction , Cardiovascular diseases , Biomedical Engineering , Space Medicine , Mechanobiology , Regenerative Medicine , Biophysics , Physiology

Research theme for competitive and other funds (17)：

2023 - 2026 Roles of cancer extracellular vesicles in hijacking macrophages and metastatic niche formation
2023 - 2025 Verification and Mechanism Elucidation of Blood-Brain Barrier Permeability of Food-Derived Functional Compounds Using Organ-on-a-Chip Systems
2021 - 2024 Next-generation mechanomedicine through the development of new mechanical load devices
2020 - 2024 Elucidation of mechanism of ischemia-reperfusion injury using heart-, brain-, and kidney-on-a-chips
2022 - 2023 Practical application of heart-on-a-chip

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Papers (71)：

Mengxue Wang, Harumi Idei, Chen Wang, Yin Liang, Yun Liu, Yusuke Matsuda, Ken Takahashi, Hiroshi Kamioka, Keiji Naruse. Effect of mechanical stretching stimulation on maturation of human iPS cell-derived cardiomyocytes co-cultured with human gingival fibroblasts. bioRxiv. 2023
Yun Liu, Rumaisa Kamran, Xiaoxia Han, Mengxue Wang, Qiang Li, Daoyue Lai, Keiji Naruse, Ken Takahashi. Development of a human heart-on-a-chip model using induced pluripotent stem cells, fibroblasts and endothelial cells. bioRxiv. 2023
Nalinrat Petpiroon, Woranan Netkueakul, Kanokwan Sukrak, Chen Wang, Yin Liang, Mengxue Wang, Yun Liu, Qiang Li, Rumaisa Kamran, Keiji Naruse, et al. Development of lung tissue models and their applications. Life Sciences. 2023
Qiang Li, Yun Liu, Mengxue Wang, Yin Liang, Keiji Naruse, Ken Takahashi. Development of a lung fibrosis model using lung epithelial cells, fibroblasts, and vascular endothelial cells. The Journal of Physiological Sciences. 2023. 73. S1. 166-166
Rumaisa Kamran, Yun Liu, Qiang Li, Keiji Naruse, Ken Takahashi. Facilitated differentiation of induced pluripotent stem cells into cardiomyocytes in a microfluidic chip. The Journal of Physiological Sciences. 2023. 73. S1. 163-163

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MISC (27)：

Takahashi K, Sasanami M, Osada H, Naruse K. Cellular mechanism of gravity sensing. 2018. 69. 2. 106-109
Takahashi K, Oh H, Iribe G, Matsuura K, Naruse K. Application of mechanobiological engineering to regenerative and reproductive medicine. Trans JSMBE. 2017. 55. 4PM-Abstract. 340-340
Takahashi K, Naruse K. Response to mechanical stimulus and cardiovascular homeostasis. Clinical Calcium. 2016. 26. 12. 1671-1676
Takahashi K. Mechanosensor. Okayama Igakkai Zasshi (Journal of Okayama Medical Association). 2016. 128. 1. 61-62
高橋賢. 書評「メカノバイオロジー」. 生物物理. 2016. 56. 1. 54-54

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Patents (4)：

Method for producing cardiomyocytes
Centrifugal microscope
Cell incubator
Preventive/therapeutic reagent for ischemic heart diseases

Books (7)：

エネルギー代謝・生体エネルギー代謝
日本生体医工学会 2022
感覚受容器
日本生体医工学会 2022
Dynamic remodeling of the heart and blood vessels: implications of health and disease
Wiley-Blackwell 2016 ISBN:9781118966143
Innovation of vascular engineering by mechano-medicine
Springer Japan 2016 ISBN:9784431548
Guyton and Hall Textbook of Medical Physiology, 11th Edition
Elsevier Japan 2010 ISBN:9784860347246

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Lectures and oral presentations (102)：

Recapitulating heart function using organ chip technology
(The 45th Annual Meeting of Japan Society of Circulation Control in Medicine)
Reconstruction and functional reproduction of heart tissue through mechanosignaling on organ chips
(63rd Annual Conference of Japanese Society for Medical and Biological Engineering)
Coculture with human gingival fibroblast cells promotes maturation of induced pluripotent stem cells into cardiac muscle cells.
Development of a live imaging system for mechanical stress-induced nitric oxide release in vascular endothelial cells on an organ-on-a-chip
(The 17th Annual Meeting of the Biomedical Society for Stress Response, Japan 2023)
Development of a lung fibrosis model using lung epithelial cells, fibroblasts, and vascular endothelial cells
(The 75th Annual Meeting of the Physiological Society of Japan Chugoku-Shikoku Division 2023)

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Works (8)：

中央西日本メディカル・イノベーション
高橋賢 2018 -
第13回国際バイオテクノロジー展/技術会議
高橋賢 2014 -
岡山メディカルイノベーション
高橋賢 2014 -
BIO tech 2014
2014 -
Bio Japan 2012 World Business Forum
2012 -

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Education (1)：

- 2006 Nagoya University Graduate School of Medicine

Professional career (1)：

Ph. D. (Medicine) (Nagoya University)

Work history (8)：

2023/06 - 現在 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
2020 - 現在 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences Research Associate Professor
2010 - 2020 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
2018 - 2019 Harvard University Wyss Institute for Biologically Inspired Engineering Visiting Scholar
2007 - 2010 Nagoya University Graduate School of Medicine Assistant Professor

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Committee career (18)：

2023/04 - 現在 Japanese Society for Medical and Biological Engineering Representative
2022/12 - 現在 Okayama University Department of Medicine Molecular Pathogenesis Organizers
2021/04 - 現在 Okayama University Department of Medicine Member, Curriculum Committee
2021/01 - 現在 The BME Society of Okayama Prefecture Secretary General
2020/10 - 現在 Pathophysiology Editorial Board

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Awards (13)：

2023/10 - Tsukuba Clinical Research & Development Organization (T-CReDO) Top Performing Team Research Studio 2023
2023/09 - The Osaka Chamber of Commerce and Industry, Kansai Innovation Initiative Finalist U-START UP KANSAI open pitch for university-based startups
2023/02 - New Energy and Industrial Technology Development Organization Finalist NEDO Technology Commercialization Program Final Examination
2023/02 - BIPROGY Inc. BIPROGY Award The 5th Okayama Tech Plan Grand Prix
2023/02 - OLBA HEALTHCARE HOLDINGS, Inc. OLBA Healthcare Prize The 5th Okayama Tech Plan Grand Prix

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Association Membership(s) (7)：

Japanese Society for Medical and Biological Engineering , The Biophysical Society of Japan , The Japanese Society for Comparative Physiology and Biochemistry , Japan Society of Aerospace and Environmental Medicine , Physiological Society of Japan , European Society of Cardiology , O-NECUS Interview Board

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