Rchr
J-GLOBAL ID:200901018061996766   Update date: Apr. 02, 2024

Kishi Hiroko

Kishi Hiroko | Kishi Hiroko
Affiliation and department:
Job title: Professor
Research field  (2): Clinical pharmacy ,  Physiology
Research keywords  (5): 細胞骨格 ,  細胞遊走 ,  Molecular Cellular Physiology ,  Smooth Muscle Physiology ,  Signal Transduction of Vascular Smooth Muscle
Research theme for competitive and other funds  (32):
  • 2021 - 2024 Elucidation of the mechanism by which paxillin controls vascular abnormal contraction
  • 2020 - 2023 中間径フィラメントビメンチンを介した新規血管平滑筋異常収縮シグナル伝達機構の解明
  • 2020 - 2023 疾患エクソソームを新規バイオマーカーとして心疾患の予防・先制医療に挑む
  • 2018 - 2021 Elucidation of the mechanism by which paxillin controls vascular abnormal contraction
  • 2015 - 2020 New Development of Foods for Preventing Vascular Diseases-Search for Biomarkers for Disease Prevention on the plasma Exosomes-
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Papers (49):
  • 重信 圭祐, 岸 博子, 宮本 達雄. 血管平滑筋異常収縮のシグナル伝達におけるvimentin断片化の役割. 山口医学. 2023. 72. 3. 135-135
  • Ying Zhang, Hiroko Kishi, Sei Kobayashi. Direct active Fyn-paxillin interaction regulates vascular smooth muscle cell migration. Journal of Smooth Muscle Research. 2023. 59. 58-66
  • Nan Li, Ying Zhang, Tomoka Morita, Hiroko Kishi, Sei Kobayashi. Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction. Journal of Pharmacological Sciences. 2022. 149. 4. 189-197
  • Qian Lu, Hiroko Kishi, Ying Zhang, Tomoka Morita, Sei Kobayashi. Hesperetin Inhibits Sphingosylphosphorylcholine-Induced Vascular Smooth Muscle Contraction by Regulating the Fyn/Rho-Kinase Pathway. Journal of Cardiovascular Pharmacology. 2022. 79. 4. 456-466
  • Kosuke Hosoba, Tomoka Morita, Ying Zhang, Hiroko Kishi, Takashi Yamamoto, Tatsuo Miyamoto. High-efficient CRISPR/Cas9-mediated gene targeting to establish cell models of ciliopathies. Methods in Cell Biology. 2022
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MISC (121):
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Patents (19):
Books (2):
  • Muscle Contraction and Cell Motility: Fundamentals and Developments
    Pan Stanford (2016/11/23), p333 -342, edited by Haruo Sugi 2016 ISBN:9789814745161
  • Molecular Mechanisms of Smooth Muscle Contraction
    R. G. Landes Company 1998 ISBN:1570595666
Lectures and oral presentations  (321):
  • The role of calpain protease and vimentin cleavage in the signal transduction of abnormal vascular smooth muscle contraction
    (10th Federation of the Asian and Oceanian Physiological Societies (FAOPS) Congress 2023)
  • 血管平滑筋収縮Ca2+-sensitizationのシグナル伝達における中間径フィラメントビメンチン断片の役割の解明
    (第65回日本平滑筋学会総会 2023)
  • 血管平滑筋異常収縮の分子機構におけるカルパイン活性化およびビメンチン断片化の役割
    (筋生理の集い 2022)
  • 血管平滑筋異常収縮のシグナル伝達におけるカルパイン活性化およびビメンチン断片化の役割の解明
    (第74回日本生理学会中国四国地方会 2022)
  • Paxillin は活性型 Fyn に直接結合することにより血管平滑筋細胞のストレスファイバー形成と細胞遊走を制御する
    (第64回日本平滑筋学会総会 白鳥常男賞受賞講演 2022)
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Education (2):
  • - 1999 Gunma University Graduate School, Division of Medicine Pharmacology
  • - 1990 Gunma University Faculty of Medicine School of Medicine
Professional career (1):
  • Doctor (Medicine) (Gunma University)
Work history (3):
  • 2023/05 - 現在 Shimane University Faculty of Medicine, Department of Environmental Physiology Professor
  • 2011/10 - 2023/04 YAMAGUCHI UNIVERSITY Graduate School of Medicine(Medicine) Associate Professor
  • 2002/09 - 2011/09 YAMAGUCHI UNIVERSITY Graduate School of Medicine(Medicine) Lecturer
Committee career (6):
  • 2023/08 - 現在 Japan Society of Smooth Muscle Research Director
  • 2011/08 - 現在 Japan Society of Smooth Muscle Research Councilor
  • 2006/03 - 現在 The Physiological Society of Japan Councilor
  • 2004/03 - 現在 The Japanese Pharmacological Society Councilor
  • 2022/08 - 2023/07 Japan Society of Smooth Muscle Research Auditor
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Awards (4):
  • 2021/08 - 日本平滑筋学会 一般演題賞 血管平滑筋異常収縮のシグナル伝達におけるカルパインの役割の解明
  • 2013/10 - 公益社団法人発明協会 会長奨励賞 血管病を予防する機能性食品の開発
  • 2012/03 - The Physiological Society of Japan Poster Award The development of a high-throughput and objective screening system to validate candidate molecules for downstream target of Fyn in SPC/Fyn/ROK pathway which mediates abnormal vascular smooth muscle contraction
  • 2007/07 - Japan Society of Smooth Muscle Research The Excellent Research Award
Association Membership(s) (7):
Physiological Society of Japan ,  The Japanese Society of Internal Medicine ,  The Japanese Vascular and Medicine Organization ,  Japan Society of Smooth Muscle Research ,  The Japanese Pharmacological Society ,  The Japanese Circulation Society ,  Biophysical Society
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