Rchr
J-GLOBAL ID：200901018111475835   Update date: Apr. 22, 2024

Sowa Yoshihiro

ソワ ヨシヒロ | Sowa Yoshihiro
Affiliation and department：
Kyoto Prefectural University of Medicine Support for Pioneering Research Initiated by the Next Generation, Center for Higher Education

About Kyoto Prefectural University of Medicine Support for Pioneering Research Initiated by the Next Generation, Center for Higher Education


Job title： Endowed Professor
Research field  (2)： Hygiene and public health (laboratory) ,  Healthcare management, medical sociology
Research keywords  (2)： 予防医学 ,  Preventive Medicine
Research theme for competitive and other funds  (30)：
  • 2022 - 2025 Development of chemoprevention of cancer by drug repurposing with the macrolides
  • 2018 - 2022 Development of novel cancer prevention strategy by the enhancement of RB family proteins
  • 2015 - 2019 Application of molecular-targeting cancer prevention to human intervention study.
  • 2016 - 2017 Molecular-targeting prevention against human papilloma virus-positive cervical cancer
  • 2014 - 2017 Development of novel molecular-targeting cancer prevention with histone methylation inhibitory dietary compound
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Papers (89)：
  • Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. Bioorganic & medicinal chemistry. 2024. 100. 117632-117632
  • Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of medicinal chemistry. 2023. 66. 22. 15171-15188
  • Yukako Nakao-Ise, Takumi Narita, Shingo Miyamoto, Motoki Watanabe, Takuji Tanaka, Yoshihiro Sowa, Yosuke Iizumi, Mitsuharu Masuda, Gen Fujii, Yasuko Hirai, et al. Induction of MYCN-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist. Journal of clinical biochemistry and nutrition. 2023. 73. 3. 191-197
  • Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of medicinal chemistry. 2023
  • Yosuke Ota, Yukihiro Itoh, Takashi Kurohara, Ritesh Singh, Elghareeb E Elboray, Chenliang Hu, Farzad Zamani, Anirban Mukherjee, Yuri Takada, Yasunobu Yamashita, et al. Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates. ACS medicinal chemistry letters. 2022. 13. 10. 1568-1573
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MISC (132)：
  • 曽和 義広. がん治療におけるエピジェネティック作用薬-The Current Status of Epigenetic Drugs in Cancer Therapy and Their Future Development and Prospects-特集 がん治療における分子標的 : その課題と未来展望. 京都府立医科大学雑誌 / 京都府立医科大学雑誌編集委員会 編. 2023. 132. 2. 75-83
  • 成田匠, 曽和義広, 渡邉元樹, 飯泉陽介, 増田光治, 武藤倫弘, 武藤倫弘. Sulforapheneによる抗酸化を介した大腸がん予防. Cytoprotection研究会プログラム/抄録. 2022. 40th
  • 渡邉 元樹, 山田 恭正, 来見田 遥一, 亀田 倫史, 助野 真美子, 飯塚 まひろ, 曽和 義広, 飯泉 陽介, 高倉 英樹, 宮本 真吾, et al. ケモプロテオミクスおよび分子動力学シミュレーションが明らかにした、延命草の苦味成分ラブドシアノンIの標的タンパク質と抗腫瘍メカニズム. 電気泳動. 2021. 65. Suppl. s67-s67
  • 渡邉 元樹, 朴 将源, 宮本 景子, 曽和 義広, 飯泉 陽介, 増田 光治, 成田 匠, 中尾 俊雅, 武藤 倫弘, 酒井 敏行. 細胞外グルタミン濃度はがん予防薬の感受性に影響する. 日本衛生学雑誌. 2021. 76. Suppl. S159-S159
  • Takahiro Hamoya, Gen Fujii, Yosuke Iizumi, Masami Komiya, Takumi Narita, Yoshihiro Sowa, Motoki Watanabe, Mitsuharu Masuda, Michihiro Mutoh. Elucidation of Wnt signaling suppression mechanism by artesunate in human colorectal cancer cells. CANCER SCIENCE. 2021. 112. 936-936
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Patents (5)：
Education (4)：
  • 1992 - 1996 Kyoto Prefectural University of Medicine
  • 1988 - 1990 Kyoto Prefectural University Graduate School of Agriculture (DC)
  • 1984 - 1988 Kyoto Prefectural University Faculty of Agriculture
  • 1981 - 1983 大阪府立旭高等学校
Professional career (1)：
  • Doctor of Medicine
Work history (10)：
  • 2024 - 現在 Kyoto Prefectural University of Medicine
  • 2022 - 2024 Kyoto Prefectural University of Medicine
  • 2008 - 2021 Kyoto Prefectural University of Medicine
  • 2003 - 2008 Kyoto Prefectural University of Medicine
  • 2004 - 2007 文部科学省 科学技術政策研究所 客員研究官
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Committee career (8)：
  • 2023/08 - 現在 PLOS ONE Academic Editor
  • 2021/02 - 現在 日本がん予防学会 認定がん予防エキスパート
  • 2021/01 - 現在 日本衛生学会 衛生学エキスパート
  • 2020/06 - 現在 Cancers Editorial Board
  • 2014/01 - 現在 日本衛生学会 編集委員(Environmental Health and Preventive Medicine)
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Awards (2)：
  • 2002 - 日本衛生学会奨励賞
  • 2000 - 青蓮賞
Association Membership(s) (4)：
日本がん分子標的治療学会 ,  日本衛生学会 ,  日本癌学会 ,  日本がん予防学会
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