Kimura Yoshinobu

キムラヨシノブ | Kimura Yoshinobu

Affiliation and department：
Job title： Professor

Research field (2)： Applied molecular and cellular biology , Applied biochemistry

Research keywords (6)：蛋白質化学 , 糖鎖生物学 , グライコミクス , Protein chemistry , Glycotechndogy , Glycobiology

Research theme for competitive and other funds (10)：

2020 - 2024 Elucidation of physiological function of free N-glycans and application of the physiological function to development of biotechnology to control the plant development and growth
2017 - 2020 Functional analysis of plant free oligosaccharides through regulation of gene-expressions of oligosaccharide-related enzymes and application of the biological functions
2015 - 2018 Preparation of functional glyco-polymers and analysis of their cellular immune activities to develop anti-pollinosis drugs
2012 - 2015 Functional analysis of cytosolic free N-glycans involved in regulation of plant growth and application of the biofunction of free N-glycans
2009 - 2011 Functional analysis of free N-glycans involved in regulation of plant differentiation.

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Papers (157)：

Naoko Okamoto, Megumi Maeda, Chiharu Yamamoto, Reo Kodama, Koichi Sugimoto, Yoshihito Shinozaki, Hiroshi Ezura, Yoshinobu Kimura. Construction of tomato plants with suppressed endo-β-N-acetylglucosaminidase activity using CRISPR-Cas9 mediated genome editing. Plant physiology and biochemistry : PPB. 2022. 190. 203-211
Shun Takata, Megumi Hayashi, Megumi Maeda, Takeshi Ishimizu, Yoshinobu Kimura. Structural features of free N-glycans in α1,3/4-fucosidase-deficient Arabidopsis thaliana: deletion of α1,3/4-fucosidase activity induced accumulation of plant complex type GN1 free N-glycans. Bioscience, biotechnology, and biochemistry. 2022. 86. 10. 1413-1416
Shota Kosaka, Makoto Katsube, Megumi Maeda, Yoshinobu Kimura. Improved method for preparation and purification of recombinant α-synuclein: high-mannose-type free N-glycan prepared from an edible bean (Vigna angulari, Azuki bean) inhibits α-synuclein aggregation. Bioscience, biotechnology, and biochemistry. 2022. 86. 6. 770-774
Chiharu Yamamoto, Mikako Ogura, Ryota Uemura, Maeda Megumi, Hiroyuki Kajiura, Ryo Misaki, Kazuhito Fujiyama, Yoshinobu Kimura. Improved assay system for acidic peptide: N-glycanase (aPNGase) activity in plant extracts. Analytical Biochemistry. 2021. 634. 114367-114367
Ryota Takeuchi, Megumi Maeda, Miran Nakano, Hiroaki Funahashi, Yoshinobu Kimura. Large-scale preparation of sialyl-Tn antigen-containing peptides from mucin-like glycoproteins in boar seminal gel. Bioscience, Biotechnology, and Biochemistry. 2021. 85. 9. 2022-2025

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MISC (9)：

M Maeda, Y Kimura. N-glycans and endo-beta-N-acetylglucosaminidase in rice cultured cells. GLYCOBIOLOGY. 2004. 14. 11. 1120-1120
M Sakaguchi, M Maeda, F Matsuda, M Kimura, M Okano, Y Kimura. Immunological activity of plant N-glycans and synthesis of neoglycopeptides and neoglycolipids carrying antigenic glycans. GLYCOBIOLOGY. 2004. 14. 11. 1120-1120
M. Okano, Y. Kimura, K. Kino, Y. Michigami, S. Sakamoto, Y. Sugata, M. Maeda, F. Matsuda, M. Kimura, T. Ogawa, et al. Roles of major oligosaccharides on Cry j 1 in human immunoglobulin E and T cell responses. Clinical and Experimental Allergy. 2004. 34. 5. 770-778
H Koga, N Araki, H Takeshima, T Nishi, T Hirota, Y Kimura, M Nakao, H Saya. Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain. ONCOGENE. 1998. 17. 7. 801-810
Y Kimura, H Koga, N Araki, N Mugita, N Fujita, H Takeshima, T Nishi, T Yamashima, TC Saido, T Yamasaki, et al. The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas. NATURE MEDICINE. 1998. 4. 8. 915-922

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Patents (1)：

木村吉伸

Books (6)：

Chemistry, Molecular Sciences and Chemical Engineering
Elsevier 2013
Chemistry, Molecular Sciences and Chemical Engineering
Elsevier 2013
Experimental Glycoscience. Glycichemistry
Springer, New York. 2008
Comprehensive Glycoscience
Elsevier, Netherland 2007
「未来を拓く糖鎖科学」
金芳堂 2005

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Lectures and oral presentations (252)：

遊離N-グリカン(FNGs)のタンパク質フォールディング促進活性とアミロイド形成阻害活性に及ぼす糖鎖構造の差異
(日本農芸化学会中四国第50回講演会(支部例会) 2018)
抗原性糖鎖の多量調製法確立を目指したタケノコ糖タンパク質糖鎖の構造解析
(日本農芸化学会中四国第50回講演会(支部例会) 2018)
ミルレクチンのアフィニティークロマトによる精製法の確立と化学構造解析
(日本農芸化学会中四国第50回講演会(支部例会) 2018)
新規人工糖鎖ポリマーを利用したダイズ核/細胞質レクチンの同定
(日本農芸化学会中四国第50回講演会(支部例会) 2018)
キトオリゴ糖のアミロイド線維形成促進活性
(日本農芸化学会中四国第50回講演会(支部例会) 2018)

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Works (1)：

研究紹介ポスター
2007 -

Education (2)：

- 1987 Kyushu University
- 1987 Kyushu University Graduate School, Division of Agriculture

Professional career (2)：

農学博士 (九州大学)
農学修士 (九州大学)

Work history (14)：

2004 - 2012 岡山大学自然科学研究科バイオサイエンス専攻教授
2004 - 2012 Professor,Bioscience,Graduate School of Natural Science and Technology,Okayama University
2012 - - 岡山大学環境生命科学研究科教授
2012 - - Professor,Graduate School of Environmental and life Science,Okayama University
2003 - 2004 Okayama University Faculty of Agriculture, Department of Agricultural Sciences

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Committee career (5)：

2013 - 日本農芸化学会中四国支部幹事
2008 - 日本農芸化学会 Biosci. Biotechnol. Biochem. 誌編集委員
2007 - 日本農芸化学会 Biosci. Biotechnol. Biochem. 誌編集委員
2005 - 日本生化学会評議員
2004 - 日本糖質学会評議員

Awards (5)：

2010 - Award for Best Presentation for International Conference on Biologically Active Substance: Okayama Bioactive 2010
2006 - Biosci. Biotechnol. Biochem. 誌優秀論文賞
2006 - Award for Excellence to Authors Publishing in Bioscience. Biotechnology and Biochemistry
1998 - 日本農芸化学奨励賞
1998 - The Japan Bioscience, Biotechnology and Agrochemistry Society Award for the Encouragement of Young Scientists

Association Membership(s) (6)：

日本アレルギー学会 , American Society for Biochemistry and Molecular Biology(ASBMB) , 日本栄養食糧学会 , 日本糖質学会 , 日本生化学会 , 日本農芸化学会

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