Rchr
J-GLOBAL ID：200901018172502894
Update date: Jan. 30, 2024
Kobayashi Hiroyuki
コバヤシ ヒロユキ | Kobayashi Hiroyuki
Affiliation and department：
Job title：
Professor
Other affiliations (3)：
Homepage URL (1)：
http://www.cp-tokai.com/
Research field (5)：
Hematology and oncology
, Other
, Pharmacology
, Clinical pharmacy
, Pharmaceuticals - chemistry and drug development
Research keywords (6)：
RNAi・リボザイム・アンチセンス
, 抗癌剤の薬剤耐性
, 分子薬理学
, RNA interference・Ribozyme・Antisense
, Anti-Cancer Drug Resistance
, Molecular Pharmacology
Research theme for competitive and other funds (17)：
- 2020 - 2023 Diagnosis and therapeutic effect of neurally mediated syncope (NMS) using fluctuation of adenylate cyclase activity
- 2015 - 2018 Candidate biomarkers for predicting drug response in cancer treatment
- 2013 - 2016 Examination of pharmacokinetics and pharmacodynamics of pyridoxamine as a protective agent of peritoneal membrane
- 2012 - 2015 Targeted therapy for anti-cancer drug resistance: Basic research
- 2010 - 2012 The Role of Adrenaline in Neurally Mediated Syncope
- 2009 - 2011 Targeted therapy for anti-cancer drug resistance mediated by several kinase pathways activation
- 2009 - 2011 Evolutionary Origin and Genetic Differentiation of Dopamine Receptor D2, D3 and D4 Genes of Japanese Domesticated Chickens
- 2007 - 2008 Functional analysis of D-serine-metabolizing enzymes using RNA interference : Application to treatment of schizophrenia
- 2003 - 2003 ランダム化RNAiライブラリーを用いた抗癌剤感受性遺伝子の探索
- 1999 - 2001 Differential blockade of opioid analgesia by gene-specific therapeutics directed against various G protein α subnits
- 1997 - 1998 Elucidation of cellular mechanism of mu-opioid receptor agonist-induced analgesia by employing antisense oligodeoxynucleotide
- 1997 - 1997 アンチセンスオリゴDNAを用いた脳内特定タンパク質の発現阻止に関する研究
- 核酸製剤の臨床応用
- 抗癌剤第一・二相試験における効果・有害事象の予測モデル
- 機能性核酸による腫瘍特異的遺伝子発現の抑制
- Application of gene-specific therapeutics to clinic
- Knockout of tumor-specific gene expression by ribozyme or RNA interference
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Papers (106)：
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Tomoyoshi Komiyama, Kengo Ayabe, Misaki Hasegawa, Marie Yoshikawa, Susumu Sakama, Kyong-Hee Lee, Atsuhiko Yagishita, Mari Amino, Eiichiro Nagata, Yuji Ikari, et al. Onset Mechanisms and Prognosis of Neurally Mediated Syncope. Reports. 2023. 6. 4. 56-56
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Tsutomu Murakami, Tomoyoshi Komiyama, Hiroyuki Kobayashi, Yuji Ikari. Gender Differences in Takotsubo Syndrome. biology. 2022. 11. 5. 653-653
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Tomoyoshi Komiyama, Hakushi Kim, Masayuki Tanaka, Sanae Isaki, Keiko Yokoyama, Akira Miyajima, Hiroyuki Kobayashi. RNA-seq and Mitochondrial DNA Analysis of Adrenal Gland Metastatic Tissue in a Patient with Renal Cell Carcinoma. biology. 2022. 11. 4
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Misaki Hasegawa, Tomoyoshi Komiyama, Kengo Ayabe, Susumu Sakama, Tetsuri Sakai, Kyong Hee Lee, Masahiro Morise, Atsuhiko Yagishita, Mari Amino, Ayumi Sasaki, et al. Diagnosis and prevention of the vasodepressor type of neurally mediated syncope in Japanese patients. PLOS ONE. 2021. 16. 6. e0251450-e0251450
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Tsutomu Murakami, Tomoyoshi Komiyama, Shingo Matsumoto, Hiroshi Kajiwara, Hiroyuki Kobayashi, Yuji Ikari. Examination of gender differences in patients with takotsubo syndrome according to left ventricular biopsy: two case reports. Journal of Medical Case Reports. 2021. 15. 281. 281-281
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MISC (56)：
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Tomoyoshi Komiyama, Eiichiro Nagata, Hiroshi Kamiguchi, Tadashi Hashida, Susumu Sakama, Kyoko Sato, Hiroshi Sakura, Koichiro Yoshioka, Hiroyuki Kobayashi. Study of adenylate cyclase activity in NMS patients based on. Autonomic Neuroscience. 2018. 210. 85-86
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森 良孝, 角田 隆俊, 都川 貴代, 竹腰 進, 湯澤 公子, 小林 広幸, 川上 純, 宮田 敏男, 深川 雅史. 腎不全腹膜透析ラットに対するピリドキサミン内服の腹膜機能保護作用の検討. 日本透析医会雑誌. 2017. 32. 1. 167-172
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小見山智義, 広川貴次, 佐藤恭子, 神口浩, 永田栄一郎, 佐倉宏, 大塚邦明, 小林広幸. 神経調節性失神とADRA2B遺伝子多型との分子相互作用機構の解明. 日本自律神経学会総会プログラム・抄録集. 2015. 68th
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Masaaki Miura, Masanobu Yoshikawa, Mariko Watanabe, Shigeru Takahashi, Junko Ajimi, Hiroyuki Kobayashi, Toshiyasu Suzuki. Effects of one or three peptidase inhibitors on antinociception of [Leu5]-enkephalin by intrathecal administration in rats. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 212P-212P
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Junko Ajimi, Masanobu Yoshikawa, Masaaki Miura, Shigeru Takahashi, Hiroyuki Kobayashi, Toshiyasu Suzuki. Effects of three peptidase inhibitors on antinociceptive action of Dynorphin A(1-17) without toxicity by intracerebroventricular administration in rats. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 212P-212P
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Books (1)：
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Anti-MDR1 ribozyme gene therapy
Methods in Molecular Medicine. Gene Therapy: Methods and Protocols 1999
Works (1)：
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薬剤耐性遺伝子のNASBA法による定量的検出
1999 -
Education (4)：
- - 2005 Vanderbilt Master of Science in Clinical Investigation
- - 2005 Vanderbilt Master of Science in Clinical Investigation
- - 1985 Keio University School of Medicine
- - 1985 Keio University Faculty of Medicine
Professional career (2)：
- Medical Doctor (Keio University)
- MSCI (Vanderbilt大学大学院)
Work history (15)：
- 2014/04 - 現在 東海大学大学院医学研究科 研究科長
- 2009/04 - 現在 Tokai University School of Medicine
- 2006/04 - 現在 Tokai University School of Medicine
- 2005/04 - 現在 東海大学大学院医学研究科 総合臨床研究センター 所長
- 2016/04 - 2022/03 Tokai University School of Medicine
- 2002 - 2006 東海大学基礎医学系 助教授
- 2003/03 - 2005/05 バンダービルド大学医療センター癌センター 研究員
- 1997 - 2002 東海大学基礎医学系 講師
- 1993 - 1997 防衛医科大学校検査部 助手
- 1993 - 1997 National Defense Medical School,
- 1990 - 1993 マウントサイナイ医科大学癌センター 研究員
- 1990 - 1993 Mount Sinai School of Medicine,
- Research Assistant
- Department of Laboratory Medicine,
- Cancer Center, Research Associate
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Committee career (4)：
- 2002 - 日本薬理学会 学術評議員
- 2000 - 日本検査血液学会 評議員
- 1997 - 日本血液学会 評議員
- 1992 - 米国癌研究学会(American Association for Cancer Research) active member
Association Membership(s) (6)：
米国臨床腫瘍学会(American Society of Clinical Oncology, ASCO)
, 日本臨床薬理学会
, 日本薬理学会
, 日本検査血液学会
, 日本血液学会
, 米国癌研究学会(American Association for Cancer Research)
