Shinoda Takehiro

シノダタケヒロ | Shinoda Takehiro

Affiliation and department：
Job title：研究員

Research field (1)： Structural biochemistry

Research theme for competitive and other funds (2)：

2018 - 2023 ヒトクローディン-11の立体構造解析に基づいた血液精巣関門の構造基盤研究
2013 - 2017 Elucidation of the role of claudin on the tight junction mechanism

Papers (8)：

Yoshimi Shimizu, Takehiro Shinoda, Yoshitaka Shirasago, Masuo Kondoh, Naoko Shinya, Kentaro Hanada, Kiyohito Yagi, Tetsuro Suzuki, Takaji Wakita, Tomomi Kimura-Someya, et al. Occludin-binding single-chain variable fragment and antigen-binding fragment antibodies prevent hepatitis C virus infection. FEBS Letters. 2020
Haruka Nasako, Risa Akizuki, Yui Takashina, Yoshinobu Ishikawa, Takehiro Shinoda, Mikako Shirouzu, Tomohiro Asai, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari. Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2020. 1867. 4. 118642-118642
Shinoda T, Shinya N, Ito K, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Yokoyama S, et al. Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin. Scientific reports. 2016. 6. 33632-33632
Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, et al. Cell-free methods to produce structurally intact mammalian membrane proteins. Scientific reports. 2016. 6
Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, et al. Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator. Proceedings of the National Academy of Sciences of the United States of America. 2014. 111. 29. 10544-10549

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MISC (14)：

奈迫遥華, 秋月梨佐, 高階優衣, 石川吉伸, 篠田雄大, 遠藤智史, 松永俊之, 五十里彰. Increase in anticancer drug-induced toxicity targeting the cell adhesion molecule claudin-2. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
清水芳実, 清水芳実, 篠田雄大, 白砂圭崇, 近藤昌夫, 新屋直子, 花田賢太郎, 八木清仁, 鈴木哲朗, 脇田隆字, et al. C型肝炎ウイルス侵入を阻害する抗OCLN低分子抗体の創出. 日本生化学会大会(Web). 2020. 93rd
新屋直子, 篠田雄大, 桂一茂, 竹本千重, 花田和晴, 井上みお, 染谷友美, 白水美香子. 大腸菌無細胞タンパク質合成技術を利用した密着結合タンパク質クローディンファミリー分子の網羅的な大量調製手法. 日本生化学会大会(Web). 2019. 92nd
篠田雄大, 新屋直子, 染谷友美, 白水美香子. ヒトクローディン-11の立体構造解析に向けたモノクローナル抗体作製. 日本生化学会大会(Web). 2019. 92nd
篠田雄大, 染谷友美. 立体構造解析のための大腸菌無細胞タンパク質合成系を用いた哺乳類由来膜タンパク質調製手法. 生化学. 2018. 90. 4

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Patents (1)：

膜タンパク質の製造方法およびその利用

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