Rchr
J-GLOBAL ID：200901018828563712
Update date: Apr. 19, 2024
Kobashigawa Yoshihiro
コバシガワ ヨシヒロ | Kobashigawa Yoshihiro
Homepage URL (1)：
http://www.pharm.kumamoto-u.ac.jp/Labs/bunseki/
Research field (2)：
Biophysics
, Structural biochemistry
Research keywords (10)：
nuclear receptor
, tyrosine kinase inhibitor
, NMR
, 薬剤耐性変異体
, チロシンキナーゼ
, シグナル伝達
, Antibody Engineering
, Protein Engineering
, structural biology
, Protein Folding
Research theme for competitive and other funds (13)：
- 2022 - 2025 多彩な構造を有する天然物の迅速評価による核内受容体の活性化・阻害と構造の相関解析
- 2021 - 2024 抗がん剤耐性克服へ向けた核内受容体の活性制御機構の解明
- 2018 - 2021 Elucidation of the molecular mechanism underlying TTR monomer unfolding and aggregate formation and its application to therapeutic approaches for FAP
- 2018 - 2021 Production of peptide that associate to the dimer interface of kinase domains
- 2017 - 2020 Developments of functional single-chain antibodies and unraveling of mechanisms of diseases associated with advanced glycation end-products
- 2017 - 2019 キナーゼ間クロストークの解明へ向けたキナーゼドメイン間相互作用の構造基盤の解明
- 2016 - 2018 Development of highly sensitive imaging method by use of functional single-chain antibodies that discriminate the structure of advanced glycation endproduct
- 2015 - 2018 Biophysical evaluation of the interaction between tyrosine kinase and drug for elucidation of drug resistant mechanism
- 2015 - 2016 ゲートキーパー変異体チロシンキナーゼによる薬剤耐性の分子基盤の解明
- 2013 - 2015 Development of the method for production of isotope labeled tyrosine kinase and its application to analyze the conformational state for drug discovery
- 2012 - 2015 Development of functional human serum albumin (HSA) mutants and studies of their ABT recognition mechanisms
- 2004 - 2007 ラフトに集積するシグナル伝達タンパク質群の構造生物学的研究
- 2001 - 2003 リゾチーム~α-ラクトアルブミンの折り畳み中間体の構造と物性
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Papers (60)：
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Sena Kamesawa, Mizuki Ogawa, Yoshiki Funakoshi, Masaya Kato, Shosei Kai, Mana Namikawa, Kyo Okazaki, Takashi Sato, Yoshihiro Kobashigawa, Hiroshi Morioka. Evaluation of the cyclic single-chain Fv antibody derived from nivolumab by biophysical analyses and in vitro cell-based bioassay. Journal of biochemistry. 2024
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Yan Du, Yoshihiro Kobashigawa, Kyo Okazaki, Mizuki Ogawa, Tomoyuki Kawaguchi, Takashi Sato, Hiroshi Morioka. Structure-based design, biophysical characterization, and biochemical application of the heterodimeric affinity purification tag based on the Schistosoma japonicum glutathione-S-transferase (SjGST) homodimer. The Journal of Biochemistry. 2024
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Yuki Inada, Yuichiro Ono, Kyo Okazaki, Takuma Yamashita, Tomoyuki Kawaguchi, Shingo Kawano, Yoshihiro Kobashigawa, Shoko Shinya, Chojiro Kojima, Tsuyoshi Shuto, et al. Hydrogen bonds connecting the N-terminal region and the DE loop stabilize the monomeric structure of transthyretin. Journal of biochemistry. 2023. 174. 4. 355-370
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Kyo Okazaki, Yoshihiro Kobashigawa, Hikari Morita, Soichiro Yamauchi, Natsuki Fukuda, Chenjiang Liu, Yuya Toyota, Takashi Sato, Hiroshi Morioka. Molecular Dynamics-Based Design and Biophysical Evaluation of Thermostable Single-Chain Fv Antibody Mutants Derived from Pharmaceutical Antibodies. ACS Omega. 2023
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Yuri Emoto, Ryoya Katayama, Emi Hibino, Sho Ishihara, Natsuko Goda, Takeshi Tenno, Yoshihiro Kobashigawa, Hiroshi Morioka, Hidekazu Hiroaki. A Cost-Effective Immobilization Method for MBP Fusion Proteins on Microtiter Plates Using a Gelatinized Starch-Agarose Mixture and Its Application for Convenient Protein-Protein Interaction Analysis. Methods and Protocols. 2023. 6. 3. 44-44
ｍore...
MISC (1)：
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森岡 弘志, 小橋川 敬博, 諏訪 喜昭, 山下 駿, 山本 珠実, 福田 夏希, 二階堂 里那, 中原 悠介, 龍野 友花, 斉藤 貴士, et al. 創薬研究の基盤となる相互作用解析 一本鎖抗体の実用化に向けた構造機能解析. 日本薬学会年会要旨集. 2014. 134年会. 1. 242-242
Patents (10)：
Books (3)：
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パートナー分析化学II
南江堂 2021 ISBN:9784524403844
-
アップデート薬学機器分析学
廣川書店 2020 ISBN:9784567258104
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ペプチド医薬品のスクリーニング・安定化・製剤化技術
技術情報協会 2017
Education (2)：
- - 2002 Hokkaido University
- - 1999 Hokkaido University Graduate School, Division of Natural Science
Professional career (1)：
- (BLANK) (Hokkaido University)
Association Membership(s) (3)：
PROTEIN SCIENCE SOCIETY OF JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN
