Rchr

J-GLOBAL ID：200901019030949006 Update date: Jan. 30, 2024

Takahashi Kazuhiro

タカハシカズヒロ | Takahashi Kazuhiro

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.med.tohoku.ac.jp/about/laboratory/077.html , http://www.journal.med.tohoku.ac.jp/editor_in_chief/page.html

Research field (4)： Physiology , Metabolism and endocrinology , Metabolism and endocrinology , Metabolism and endocrinology

Research keywords (8)： Applied physiology , Cardiovascular endocrinology , Neuroendocrinology , Prorenin receptor , Autophagy , Tumor biology , Biologically active peptides , Endocrinology and Metabolism

Research theme for competitive and other funds (30)：

1992 - 現在 Applied physiology
1985 - 現在 Endocrinology and Metabolism
2016 - 2019 Effects of exercise and drug therapies in heart failure models
2013 - 2016 (Pro)renin receptor in renal and cardiovascular injuries.
2013 - 2015 The roles of (pro)renin receptor in cerebral, cardiac and renal diseases

2012 - 2015 Mechanism behind cardioprotective effect after chronic exercise in heart failure rats.

2011 - 2013 Studies on the novel factor in the renin-angiotensin system in the pathophysiology of the cardio-renal anemia syndrome

2011 - 2012 (Pro)renin receptor in cerebral, cardiac and renal diseases

2009 - 2011 Novel hormones and receptors in renal and cardiovascular injuries.

2009 - 2011 Expression of vasoactive substances in heart failure model of exercise therapy.

2007 - 2008 Molecular mechanism of the novel hormone/receptor systems in renal and cardiovascular dysfunction

2006 - 2007 Studies on novel peptide hormones in the pathophy siology of obesity and hypertension

2002 - 2003 ヒト脳におけるプロゲステロン産生と作用-プロゲステロンはneurosteroidか?-

2002 - 2003 睡眠時無呼吸に対する防御機構としての低酸素応答の分子基盤

2001 - 2003 PLASMA LEVELS OF UROTENSIN II AND ITS URINARY EXCRETION IN PATIENTS WITH DIABETES MELLITUS : RELATION WITH DIABETIC NEPHROPATHY

2001 - 2003 Studies on expression of bioactive substances under hypoxia and relation to diseases

2001 - 2002 神経ペプチドの血液脳関門通過性とペプチドトランスポーターの解析

1999 - 2001 The analysis of intratumoral estrogen metabolism and production in human breast and endometrial carcinoma

1999 - 1999 多種の腫瘍から産生・分泌される新しい増殖制御因子、アドレノメデュリンの研究

1998 - 1999 Molecular basis of the structural and functional multiplicity of microphthalmia-associated transcription factor

1997 - 1998 個体老化のモデルとしての白髪形成の分子機構の解明

1997 - 1998 Heme oxygenase in the brain

1996 - 1997 Analysis of in situ estrogen production in human osteoporosis.

1996 - 1997 Molecular mechanisms of pigment cell differentiation.

1995 - 1996 Development of a new method for detecting gene expression in a single cell and its medical application.

1995 - 1995 コルチコトロピン放出ホルモン遺伝子の転写調節機構の解析

1995 - 1995 神経線維腫症1型の原因遺伝子産物の新しい生理機能の解明

1994 - 1995 Analysis of growth factors and cytokines in human adrenocortical steroidogenesis

1994 - 1994 下垂体アデニレートシクラーゼ活性化ペプチドの生理機能の解析

1993 - 1993 新しく発見された神経ペプチド,メラニン凝集ホルモンの生理機能解析

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Papers (284)：

Hiroki Ito, Takuo Hirose, Shigemitsu Sato, Chika Takahashi, Risa Ishikawa, Akari Endo, Ayaka Kamada, Ikuko Oba-Yabana, Tomoyoshi Kimura, Kazuhiro Murakami, et al. Pericyte detachment and renal congestion involve interstitial injury and fibrosis in Dahl salt-sensitive rats and humans with heart failure. Hypertension research : official journal of the Japanese Society of Hypertension. 2023
Kazuhiro Takahashi. Tweets about War, Medicine and Humanity: Do You Hear the People Tweet in Ukraine?. The Tohoku journal of experimental medicine. 2023. 259. 3. 175-176
Shigemitsu Sato, Takuo Hirose, Koji Ohba, Fumihiko Watanabe, Tomoki Watanabe, Kazuya Minato, Akari Endo, Hiroki Ito, Takefumi Mori, Kazuhiro Takahashi. (Pro)renin receptor and insulin signalling regulate cell proliferation in MCF-7 breast cancer cells. Journal of biochemistry. 2022. 172. 6. 355-363
Kazuhiro Takahashi. Heart peptides and HFpEF (heart failure with preserved ejection fraction). Peptides. 2022. 157. 170866-170866
Go Anan, Takuo Hirose, Daisuke Kikuchi, Chika Takahashi, Akari Endo, Hiroki Ito, Shigemitsu Sato, Shingo Nakayama, Hideaki Hashimoto, Katsuya Ishiyama, et al. Inhibition of Sodium-glucose Cotransporter 2 Suppresses Renal Stone Formation. Pharmacological Research. 2022. 186. 106524-106524

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MISC (238)：

廣瀬卓男, 廣瀬卓男, 伊藤大樹, 伊藤大樹, 遠藤明里, 遠藤明里, 加藤季子, 石川里紗, 佐藤峻行, 高橋知香, et al. 腎うっ血に伴う腎間質線維化に対するマイオカイン・アイリシンの保護効果. 日本内分泌学会雑誌. 2022. 98. 1
山越聖子, 伊藤修, 伊藤修, 戎栄, 大崎雄介, 中村貴裕, 廣瀬卓男, 高橋和広, 森建文, 戸恒和人, et al. 食塩感受性ラットにおける高食塩食摂取による腎(プロ)レニン受容体発現調節と尿中L型脂肪酸結合蛋白変化. 腎と脂質研究会プログラム・抄録集. 2020. 32nd
山越聖子, 伊藤修, 大崎雄介, 中村貴裕, 廣瀬卓男, 高橋和広, 森建文, 戸恒和人, 戎栄, 上月正博. Dahl食塩感受性高血圧ラットにおける高食塩食摂取による(プロ)レニン受容体腎内発現と腎間質線維化. 日本腎臓学会誌(Web). 2020. 62. 4
山越聖子, 伊藤修, 戎栄, 大崎雄介, 中村貴裕, 高橋和広, 森建文, 伊藤貞嘉, 戸恒和人, 上月正博. Dahl食塩感受性ラットの腎ネフロンセグメントにおける高食塩食摂取による(プロ)レニン受容体発現とキサンチンオキシダーゼ活性の変化. 痛風と尿酸・核酸. 2019. 43. 1. 60-60
高橋和広. 人工知能(AI)と少子高齢化時代における臨床検査技師養成教育雨にも負けず、風にも負けず、AIにも負けず. 東北大学医学部保健学科紀要. 2019. 28. 1. 15-20

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Books (11)：

内分泌性高血圧診療マニュアル改訂第2版
診断と治療社 2017 ISBN:9784787822611
Handbook of Biologically Active Peptides Second Edition. Kastin A, ed.
Elsevier 2013
内分泌性高血圧診療マニュアル
診断と治療社 2010
Endocrine Pathology: Differential Diagnosis and Molecular Advances
Springer New York Dordrecht Heidelberg London 2010
Handbook of Biologically Active Peptides
Elsevier 2006

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Lectures and oral presentations (240)：

Suppression of (pro)renin receptor expression inhibits autophagy and decreases cell proliferation in cultured cancer cells.
(Physiology 2019 2019)
High salt intake-increased (pro)renin receptor expression is exaggerated in the kidney of Dahl salt-sensitive rats.
(International Symposium of Aldosterone and Related Substances in Hypertension 2019 2019)
Inhibition of autophagy induced accumulation of soluble (pro)renin receptor in cultured cancer cells.
(International Symposium of Aldosterone and Related Substances in Hypertension 2019 2019)
Mechanism of cell proliferative effects by insulin and (pro)renin receptor in human cancer cultured cells.
(International Symposium of Aldosterone and Related Substances in Hypertension 2019 2019)
Effects of anti-cancer agents on soluble (pro)renin receptor expression in cultured human breast cancer cells and lung cancer cells.
(International Symposium of Aldosterone and Related Substances in Hypertension 2019 2019)

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Education (1)：

- 1983 Tohoku University Faculty of Medicine

Professional career (1)：

医学博士 (Tohoku University)

Work history (12)：

2008/04 - 現在 Tohoku University Graduate School of Medicine Professor
2005/04 - 2008/03 Tohoku University School of Medicine Professor
1999/04 - 2005/03 Tohoku University Graduate School of Medicine Associate Professor
1998/09 - 1999/03 Tohoku University School of Medicine Associate Professor
1996/08 - 1998/08 Tohoku University School of Medicine Lecturer

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Committee career (13)：

2021/01 - 現在 Tohoku Journal of Experimental Medicine Editor-in-Chief
2014/04 - 現在 Tohoku Journal of Experimental Medicine Editorial board member
2005/04 - 現在 The Lancet Editorial Consultant
2003/04 - 現在日本腎臓学会評議員
2001/01 - 現在 PEPTIDES Editorial board member

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Awards (7)：

2003/03/01 - Pigment Cell Research Pigment Cell Research Outstanding Article Award
2002/06 - 日本内分泌学会 Research Award from the Japan Endocrine Society 新規生理活性ペプチド研究を通した内分泌学の新規分野への発展
2002/05 - インテリジェント・コスモス A grant from Intelligent Cosmos 魚類から発見されたホルモンの研究を、先端医療に生かす
2001/01 - 東北大学医学部 Gold Medal from Tohoku University School of Medicine 多機能性ペプチド、アドレノメデュリンを通した分子内分泌学の境界領域研究
1999/11 - 持田記念医学薬学振興財団 Mochida Research Award for Young Investigator 虚血性心疾患における血管拡張性物質の転写調節機構の解析

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Association Membership(s) (7)：

日本高血圧学会、評議員、特別正会員 , 日本心血管内分泌代謝学会、評議員 , 日本神経内分泌学会、評議員 , 日本腎臓学会、評議員 , 日本内科学会 , The Physiological Society , Japan Endocrine Society

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