Maeda Shiro

マエダシロウ | Maeda Shiro

Affiliation and department：
Job title： Professor

Research field (3)： Nephrology , Metabolism and endocrinology , Genetics

Research keywords (5)： Okinawa Bio-Information Bank , Diabetic Nephropathy , Diabetes Mellitus , Genome-wide association study , Human Genetics

Research theme for competitive and other funds (26)：

2023 - 2027 Deciphering the prehistoric peopling of the Ryukyu Archipelago based on ancient genome data
2023 - 2026 生活習慣病リスクと関連する疾患感受性ミトコンドリアゲノム多型の網羅的探索
2021 - 2024 銀ナノ錯体バイオチップを活用したヌクレオソーム解析による新規大腸癌診断法の確立
2020 - 2023 新たなゲノム創薬手法により同定されたKIF11阻害薬の耐糖能改善機序の解明
2017 - 2020 Identification of novel therapeutic target for type 2 diabetes through genome-based drug discovery

2014 - 2018 Comprehensive analysis of autophagy in the pathogenesis of diabetes and its complications

2014 - 2017 Functional analysis of GWAS-derived type 2 diabetes susceptibility genes

2013 - 2016 Fatty acid composition and diabetic nephropathy

2012 - 2015 Assessing the clinical utility of the genetic information using the genotype data for GWAS-derived type 2 diabetes susceptibility variants in a Japanese population.

2011 - 2013 Investigation for the role of UBE2E2 in insulin secretory machinery and its molecular mechanisms

2010 - 2012 Investigation of molecular mechanisms for the regulation of insulin secretion by KCNQ1

2010 - 2011 The relationship between lowered expression level of novel mitochondrial regulator-A and onset of diabetes mellitus

2009 - 2011 Role of TFAP2B as environment response gene on Metabolic Syndrome

2009 - 2011 A new strategy for the treatment of diabetic nephropathy : regulation of AMPK/ACC pathway in podocyte.

2007 - 2009 The role of AP2β, the molecule which leads to adipocyte hypertrophy, in the metabolic syndrome

2007 - 2008 Regulation of Adipokine Expression on Metabolic Syndrome

2007 - 2008 Molecular mechanism for the contribution of TFAP2B and KLF7 to the onset of type 2 diabetes

2006 - 2008 Effect of diet and exercise education on prevention of life style-related diseas

2005 - 2007 Elucidation of the mechanism for the activation of transcription factors and gene response in the aorta of the postprandial state ofrata

2005 - 2005 ゲノム疫学研究・薬理ゲノミクスに基づく新たな糖尿病合併症治療戦略の開発

2004 - 2005 脂肪細胞におけるインスリン感受性獲得の分子機構と肥大化誘導分子の同定

2002 - 2005 OXIDATIVE STRESS AND EXERCISE : ESTABLISHMENT OF EXERCISE THERAPY FOR HEALTH PROMOTION AND PREVENTION OF DIABETES

2004 - 2004 糖尿病合併症・糖尿病薬剤感受性遺伝子の同定と新たな治療戦略への展開

2003 - 2003 糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子の検索

2000 - 2001 腎糸球体硬化におけるCalcineurin-NFAT経路の重要性とその分子機構

1997 - 1999 The molecular mechanism of increase of TGF-β expression in diabetic glomeruli

Show all

Papers (73)：

Xiaoxi Liu, Masatoshi Matsunami, Momoko Horikoshi, Shuji Ito, Yuki Ishikawa, Kunihiko Suzuki, Yukihide Momozawa, Shumpei Niida, Ryosuke Kimura, Kouichi Ozaki, et al. Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations. Molecular biology and evolution. 2023. 40. 10
Kae Koganebuchi, Masatoshi Matsunami, Minako Imamura, Yosuke Kawai, Yuki Hitomi, Katsushi Tokunaga, Shiro Maeda, Hajime Ishida, Ryosuke Kimura. Demographic history of Ryukyu islanders at the southern part of the Japanese Archipelago inferred from whole-genome resequencing data. Journal of human genetics. 2023
今村美菜子, 松波雅俊, 前田士郎. 2型糖尿病および糖尿病合併症のゲノム研究の成果と疾患予防への応用. 糖尿病. 2023. 66. 5. 385-386
松波雅俊, 今村美菜子, 小金渕佳江, 堀越桃子, 寺尾知可史, 植田真一郎, 石田肇, 木村亮介, 前田士郎. 沖縄県での精密医療を目指したヒトゲノム研究. 糖尿病. 2023. 66. 1. 49-50
内里開, 松波雅俊, 今村美菜子, 前田士郎. 沖縄県民を対象としたゲノムワイド相関解析(GWAS)によるBMI関連領域の同定. 糖尿病. 2023. 66. 1. 87-87

ｍore...

MISC (32)：

松波雅俊, 前田士郎. 【個人差の理解へ向かう肥満症研究 GWAS、エピゲノム、腸内細菌、栄養学的知見から多様な病態を解明し、Precision Medicineをめざす】(第4章)肥満症の個人差 Polygenic Risk Score Precision Medicine実現における有用性. 実験医学. 2021. 39. 5. 755-760
大城匡恭, 松波雅俊, 今村美菜子, 前田士郎. ゲノムワイド相関解析によるAST、ALTの関連領域の同定. 琉球医学会誌. 2021. 40. 1-4. 61-61
上原慶史郎, 松波雅俊, 今村美菜子, 前田士郎. 沖縄県民を対象としたゲノムワイド相関解析による血圧関連領域の同定. 琉球医学会誌. 2021. 40. 1-4. 64-64
竹田和輝, 松波雅俊, 今村美菜子, 前田士郎. 血中脂質に関するゲノムワイド相関解析とゲノム情報を利用した脂質異常症発症予測の試み. 琉球医学会誌. 2021. 40. 1-4. 67-67
今村美菜子, 高橋篤, 松波雅俊, 堀越桃子, 前田士郎. 網膜症日本人2型糖尿病集団における糖尿病網膜症のゲノムワイド関連解析. 糖尿病合併症. 2020. 34. Suppl.1. 248-248

ｍore...

Education (2)：

1986 - 1990 Shiga University of Medical Science Graduate School of Medicine
1979 - 1985 Shiga University of Medical Science Undergraduate School of Medicine Faculty of Medicine

Professional career (1)：

医学博士 (滋賀医科大学)

Work history (7)：

2014/08 - 現在 Graduate School of Medicine, University of the Ryukyus Department of Advanced Genomic and Laboratory Medicine Professor
2013/04 - 2016/03 RIKEN Center for Integrative Medical Sciences Laboratory for Endocrinology and Metabolism Laboratory Head
2008/04 - 2013/03 RIKEN Center for Genomic Medicine Laboratory for Endocrinology, Metabolism and Kidney Diseases Laboratory Head
2001/04 - 2008/03 RIKEN SNP Research Center Laboratory for diabetic nephropathy Laboratory Head
1999/01 - 2000/09 Shiga University of Medical Science Third Department of Internal Medicine Assistant professor

Show all

Committee career (4)：

日本医療検査科学会評議員
日本臨床化学会評議員
日本臨床検査医学会評議員
日本糖尿病学会学術評議員

Association Membership(s) (14)：

International Society of Nephrology , Asian Association for the study of Diabetes , European Association for the Study of Diabetes , American Society of Nephrology , American Diabetes Association , The International Academy of Sportology , The Japan Society of Human Genetics , The Japanese Society of Internal Medicine , The Japan Society of Diabetic Complications , The Japan Association for Clinical Laboratory Science , Japan Society of Clinical Chemistry , Japanese Society of Laboratory Medicine , Japanese Society of Nephrology , Japan Diabetes Association

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page