Rchr
J-GLOBAL ID：200901019288465470   Update date: Apr. 08, 2024

Kawakami Junji

カワカミ ジュンジ | Kawakami Junji
Affiliation and department：
Konan University Faculty of Frontiers of Innovative Research in Science and Technology, Department of Nanobiochemistry

About Konan University Faculty of Frontiers of Innovative Research in Science and Technology, Department of Nanobiochemistry


Research field  (4)： Molecular biology ,  Structural biochemistry ,  Biochemistry ,  Molecular biochemistry
Research keywords  (9)： nucleic acid therapeutics ,  antisense ,  aptamer ,  生物物理化学 ,  試験管内分子進化 ,  リボザイム ,  physical biochemistry ,  in vitro molecular evolution ,  ribozyme
Research theme for competitive and other funds  (6)：
  • 2009 - 2011 Development of novel nucleic acid materials that efficiently work in the intracellular molecular environment
  • 2004 - 2006 ヘアピンループDNA/RNAを認識するモデルペプチドの速度論的機能評価
  • 2001 - 2004 Evaluation of RNA cleavage reaction based on the prediction parameters for nucleic acid structures
  • 1998 - 1999 核酸の鏡像異性体合成と、その相互作用の研究
  • 生命分子の構造-活性相関に関する研究
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Papers (75)：
  • Hiroyuki Togawa, Takashi Okubo, Kazuki Horiuchi, Takao Yamaguchi, Elisa Tomita-Sudo, Tomoka Akita, Junji Kawakami, Satoshi Obika. Separation of the diastereomers of phosphorothioated siRNAs by anion-exchange chromatography under non-denaturing conditions. Journal of Chromatography A. 2024. 1721. 464847-464847
  • Kaoru Karasawa, Eva Duchoslav, Lyle Burton, Junji Kawakami, Takashi Baba. Sequencing of Morpholino Antisense Oligonucleotides Using Electron Capture Dissociation Mass Spectrometry. Analytical Chemistry. 2023. 95. 44. 16352-16358
  • Takahiro Yaguchi, Misaki Kameno, Hirofumi Taira, Junji Kawakami. Mitochondrial Dynamics of Bcl-2 Family Proteins during 17-β-Estradiol-Induced Apoptosis Correlate with the Malignancy of Endometrial Cancer Cells. Biochemstry. 2023. 62. 21. 3041-3049
  • Tomoka Akita, Elisa Tomita-Sudo, Shin Itoh, Nae Sakimoto, Takeshi Masuda, Akifumi Nakamura, Yoshiyuki Onishi, Makoto Koizumi, Junji Kawakami. Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes. Nucleosides, Nucleotides & Nucleic Acids. 2023
  • 川上 純司. 製造委託の際に知っておきたい核酸医薬の特性ー品質と安全性評価面を中心に. Pharm Tech Japan. 2022. 38. 12. 2017-2022
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MISC (14)：
  • 秋田 智香, 冨田 恵麗沙, 川上 純司. 核酸医療の基礎知識 修飾核酸. 月刊 臨床神経科学. 2023. 41. 5. 639-642
  • 日本発の核酸医薬を世界に向けて. SCAS NEWS. 2023. 23-Jan. 1-2
  • LC/MSを使用したオリゴ核酸の不純物分析. Medical Science Digest. 2023. 49. 14. 780-782
  • 廣瀬賢治, 吉田徳幸, 寺崎真樹, 瀬崎浩史, 唐澤薫, 岩崎了教, 高原健太郎, 滝口直美, 関口光明, 南海浩一, et al. Comparison of Analysis Data of Model Oligonucleotide Therapeutics Obtained with Different Types of Liquid Chromatograph-Mass Spectrometers. 医薬品医療機器レギュラトリーサイエンス. 2023. 54. 5
  • 秋田 智香, 川上 純司. 核酸医薬の化学 総論 -修飾核酸と機能評価. 実験医学. 2021. 39. 17. 2716-2722
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Books (8)：
  • 不純物の分析法と化学物質の取り扱い
    技術情報協会 2024
  • 核酸医薬品のCMC管理戦略 -品質評価・不純物管理-
    サイエンス&テクノロジー 2022 ISBN:9784864282925
  • 実験医学 (Experimental Medicine)
    実験医学 2021
  • 核酸科学ハンドブック
    講談社 2020 ISBN:9784065207864
  • 医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略
    情報機構 2019
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Lectures and oral presentations  (239)：
  • Ligation reaction on Capped RNA substrates by a Ligase Ribozyme
    (The 50th International Symposium on Nucleic Acids Chemistry The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry 2023)
  • Sequences that destabilize DNA/RNA duplexes
    (The 50th International Symposium on Nucleic Acids Chemistry The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry 2023)
  • Sequence-dependent effects on kinetic parameters of nucleic acid duplex formation
    (The 50th International Symposium on Nucleic Acids Chemistry The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry 2023)
  • Sequence-dependent effects on kinetic parameters of nucleic acid duplex formation
    (The 50th International Symposium on Nucleic Acids Chemistry The 7th Annual Meeting of Japan Society of Nucleic Acids Chemistry 2023)
  • Assessment of Subtle HOS Changes in Oligonucleotide Therapeutics Using High-Throughput Circular Dichroism Spectrometer HTCD Plus and a program qHOS
    (19th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS, at Barcelona) 2023)
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Education (3)：
  • 1991 - 1994 Graduate School of Hokkaido University Pharmaceutical Sciences
  • 1989 - 1991 Graduate School of Osaka University Pharmaceutical Sciences
  • 1985 - 1989 Osaka University Pharmaceutical Sciences
Professional career (1)：
  • Ph. D. (Hokkaido University)
Work history (11)：
  • 2009 - 現在 甲南大学 フロンティアサイエンス学部 教授
  • 2009 - 現在 Professor, Department of Nanobiochemistry, FIRST, Konan University
  • 2005 - 2009 Konan University Faculty of Science and Engineering
  • 2005 - 2009 Associate Professor, Faculty of Science and Engineering, Konan University
  • 1996 - 2005 Konan University
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Committee career (5)：
  • 2016/09 - 現在 日本核酸化学会 評議員
  • 2015/12 - 現在 日本核酸医薬学会 事務局長
  • 2015/04 - 現在 日本核酸医薬学会 評議員
  • 2004/04 - 2017/03 高分子学会 バイオ・高分子研究会 運営委員
  • 2005/04 - 2016/03 アンチセンスDNA/RNA研究会 運営委員
Association Membership(s) (8)：
The RNA Society ,  AAAS ,  高分子学会 ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  日本薬学会 ,  日本化学会 ,  NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN ,  日本核酸化学会
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