Rchr
J-GLOBAL ID:200901020128097057   Update date: Apr. 18, 2024

Masunaga Shin-ichiro

マスナガ シンイチロウ | Masunaga Shin-ichiro
Affiliation and department:
Job title: Associate Professor,Associate Professor
Research field  (1): Radiology
Research keywords  (6): Hyperthermia ,  Neutron capture therapy ,  放射線生物学 ,  放射線腫瘍学 ,  Radiation Biology ,  Radiation Oncology
Research theme for competitive and other funds  (42):
  • 2019 - 2023 二重特異性抗体を用いたBNCTホウ素デリバリーシステムの開発
  • 2019 - 2022 Interrelationship analysis of the characteristics of quiescent tumor cells with tumor heterogeneity and cancer stem cell nature, referring to application to cancer therapy
  • 2018 - 2021 Analyses of selective cytotoxicity of the anti-diabetic biguanide drug, Metformin, in solid tumor specific microenvironment
  • 2015 - 2019 Analysis of neoplastic cell-specific fatal effects with reactive oxygen species abnormality derived from compound from plant species, piperlongumine
  • 2015 - 2019 腫瘍内微小環境特性の解析成果を応用した局所腫瘍制御と遠隔転移抑制の同時達成の試み
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Papers (369):
  • Tong Ying, Gao Zhongming, Imamichi Shoji, Sanada Yu, 佐々木 由香, 野崎 中成, Suzuki Minoru, Masunaga Shinichiro, 益谷 美都子. BNCT後の早期反応バイオマーカーとしてのHMGB1の動的プロファイル(Dynamic profile of HMGB1 as a biomarker for the early response after BNCT). 日本癌学会総会記事. 2023. 82回. 2156-2156
  • Naonori Hu, Minoru Suzuki, Shin-ichiro Masunaga, Genro Kashino, Yuko Kinashi, Yi-Wen Chen, Yong Liu, Koki Uehara, Toshinori Mitsumoto, Hiroki Tanaka, et al. Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study. Journal of Radiation Research. 2023
  • Shoji Imamichi, Lichao Chen, Tasuku Ito, Ying Tong, Takae Onodera, Yuka Sasaki, Satoshi Nakamura, PierLuigi Mauri, Yu Sanada, Hiroshi Igaki, et al. Correction: Imamichi et al. Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy. Biology 2022, 11, 420. Biology. 2023. 12. 8
  • Tsubasa Watanabe, Tomohiro Yoshikawa, Hiroki Tanaka, Yuko Kinashi, Genro Kashino, Shin-Ichiro Masunaga, Toshimitsu Hayashi, Koki Uehara, Koji Ono, Minoru Suzuki. Pharmacokinetic Study of 14C-Radiolabeled p-Boronophenylalanine (BPA) in Sorbitol Solution and the Treatment Outcome of BPA-Based Boron Neutron Capture Therapy on a Tumor-Bearing Mouse Model. European journal of drug metabolism and pharmacokinetics. 2023. 48. 4. 443-453
  • Shin-Ichiro Masunaga, Yu Sanada, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Mitsunori Kirihata, Koji Ono. The impact of TP53 status of tumor cells including the type and the concentration of administered 10B delivery agents on compound biological effectiveness in boron neutron capture therapy. Journal of radiation research. 2023. 64. 2. 399-411
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MISC (713):
  • GAO Zhongming, TONG Ying, IMAMICHI Shoji, IMAMICHI Shoji, IMAMICHI Shoji, SANADA Yu, SUZUKI Minoru, 石合正道, 石合正道, MASUNAGA Shinichiro, et al. The biological analysis of noncoding RNA SNHG12 after boron neutron capture therapy (BNCT). 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 新津明穂, 山本凌大, 真田悠生, 渡邉翼, 増永慎一郎, 増永慎一郎, 辻美恵子, 平山佑, 永澤秀子. Development of a novel boron carrier for BNCT exploiting a tumor-specific amino acid transport system. 日本薬学会年会要旨集(Web). 2023. 143rd
  • TONG Ying, CHEN Lichao, IMAMICHI Shoji, IMAMICHI Shoji, SANADA Yu, 佐々木由香, 佐々木由香, 野崎中成, 野崎中成, ISHIAI Masamichi, et al. The roles of GM-CSF and inflammatory/immune cascades in the tumor cell response to boron neutron capture therapy. 日本癌学会学術総会抄録集(Web). 2022. 81st
  • 杉浦幸作, 板尾琴子, 金井大成, 櫻井良憲, 真田悠生, 増永慎一郎, 長崎健, 大谷亨. Evaluation of hyperbranched polyglycerol-graft-γ-cyclodextrin for neutron capture therapy. シクロデキストリンシンポジウム講演要旨集. 2021. 37th
  • 増永慎一郎, 真田悠生, 永澤秀子, 原田浩, 平山亮一, 笠岡敏, 長崎健, 宇都義浩, 安井博宣, 益谷美都子, et al. Analyzing tumor microenvironment and exploiting its characteristics in search of optimizing cancer therapy including neutron capture therapy. KURNS-EKR (Web). 2021. 10
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Books (45):
  • 分割照射の基礎 『がん・放射線療法 2017』
    学研メディカル秀潤社 2017
  • Tumor Microenvironment and Hyperthermia
    Springer Singapore 2016 ISBN:9789811007194
  • 放射線治療中でも普通に生活できますか?がん放射線治療のしくみについておしえてください。放射線治療は、なぜがんに有効なのですか? 『患者さんと家族のための放射線治療Q&A 2015年版』
    金原出版 2015
  • 1-2 治療抵抗性腫瘍細胞の放射線増感 『新しい酵素標的・増感放射線療法 KORTUCの基礎と臨床』
    篠原出版新社 2015
  • 2-61 放射線生物学 『チームで取り組む 乳がん放射線療法』
    メディカル教育研究社 2013
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Lectures and oral presentations  (539):
  • Usefulness of Combination With Both Continuous Administration of Hypoxic Cytotoxin, Tirapazamine and Mild Temperature Hyperthermia in Boron Neutron Capture Therapy in Terms of Local Tumor Control and Lung Metastatic Potential.
    (The 106th Scientific Assembry and Annual Meeting, Radiological Society of North America 2020)
  • 休止期腫瘍細胞特性と癌幹細胞性との関連性解析と癌治療への応用
    (第22回菅原・大西記念癌治療増感シンポジウム 2020)
  • Significance of manipulating tumor hypoxia and radiation dose rate in terms of local tumor control and distant lung metastasis
    (105th Scientific Assembry and Annual Meeting 2019)
  • Cellular uptake mechanism of kojic acod modified o-carborane as a boron drug toward melanoma-targeting BNCT
    (10th Young Researchers BNCT Meeting 2019)
  • Development of neutron irradiation field for cells and small animals using cyclotron-basedepithermal neutron source
    (10th Young Researchers BNCT Meeting 2019)
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Education (4):
  • - 1991 Kyoto University
  • - 1991 Kyoto University Graduate School, Division of Medicine Radiation Oncololgy
  • - 1983 Kyoto University Faculty of Medicine Department of Medical Science
  • - 1983 Kyoto University Faculty of Medicine Faculty of Medicine
Professional career (1):
  • M. D., D. Med. Sc. (Kyoto University) (Kyoto University)
Work history (15):
  • 2013/02 - 現在 Kyoto University
  • 1996/08 - Kyoto University Research Reactor Institute
  • 1996/08 - Associate Professor, Research Reactor Institute,
  • 1993/09 - 1995/01 米国ロチェスター 大学放射線腫瘍学教室 博士後研究員
  • 1995/01 - Kyoto University Research Reactor Institute
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Committee career (28):
  • 2010 - 現在 日本放射線腫瘍学会生物部会 常任幹事
  • 2008 - 現在 放射線医学総合研究所重粒子線がん治療装置等共同利用運営委員会 委員
  • 2006 - 現在 日本癌治療学会 雑誌Editorial Board
  • 2006 - 現在 日本放射線影響学会 雑誌編集委員
  • 2004 - 現在 日本放射線影響学会 雑誌編集査読委員
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Awards (15):
  • 2020/06 - 日本医学放射線学会 第79回日本医学放射線学会総会 CyPos賞(Silver Medal) ホウ素中性子捕捉療法における低酸素細胞毒の連続的投与と低温度温熱療法の同時併用処置の有用性
  • 2017 - 日本医学放射線学会 第76回総会CyPos賞(Bronze Medal) 酸素化休止期腫瘍細胞における放射線照射後回復に対するチラパザミン投与や低温度温熱処置の効果
  • 2016 - 日本放射線影響学会 平成28年度学会賞 腫瘍内微小環境特性の解析成果を応用する局所腫瘍制御と遠隔転移抑制の同時達成を目指す試み
  • 2016 - 京都府医師会 第42回京都医学会学術研鑽賞
  • 2015 - 日本医学放射線学会 第74回総会CyPos賞(Gold Medal) 局所腫瘍効果と肺転移抑制能から見たγ線照射時における分割サリドマイド投与併用の意義
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Association Membership(s) (15):
International Society of Neutron Capture Therapy for Cancer ,  日本放射線腫瘍学会 ,  日本放射線影響学会 ,  日本癌治療学会 ,  日本癌学会 ,  日本医学放射線学会 ,  日本ハイパーサーミア学会 ,  日本アイソトープ協会 ,  Japanese Society for Thrapeutic Radiology and Oncology ,  Japan Radiation Research Society ,  Japan Sciety of Clinical Oncology ,  Japanese Cancer Association ,  Japan Radiological Society ,  Japanese Society for Hyperthermic Oncology ,  Japan Radioisotope Association
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