Research theme for competitive and other funds (14)：
2020 - 2023 Molecular mechanism of extreme environmental resistance revealed from structural properties of proteins embedded in sugar glass
2016 - 2019 Elucidation of molecular mechanism of biological effect by structural characterization of ultra-fine bubble
2013 - 2016 Study of functional structure of protein and biomembrane by the developement of resonant X-ray solution scattering in wide-energy range
2010 - 2012 Study of protein folding under crowding and confined-space condition that mimics intracellular environments
2008 - 2010 Development of a Physically Bent Cylindroid Mirror for Grazing-Incidence Small-Angle Scattering with a Focused Neutron Beam
2007 - 2009 Establishment of hierarchical structure analysis of proteins insolutions by high-throughput of wide-angle X-rays scattering usingsynchrotron radiation source
2008 - 2008 Development and application of new glycolipid-containing drug nanocapsules with high retention and selectivity
2000 - 2001 Structure formation of biopolymer solution under magnetic field / magnetic field gradient ・ Elucidation of mechanism of concentration fluctuation and crystallization control
1992 - 1993 Development of new solution scattering method using ferrofluid
1991 - 1991 Synchrotron radiation X-ray solution scattering of biological material by magnetic field orientation at low temperature
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Papers (130)：
Mitsuhiro Hirai, Shigeki Arai, Hiroki Iwase. Fibrillization Process of Human Amyloid-Beta Protein (1-40) under a Molecular Crowding Environment Mimicking the Interior of Living Cells Using Cell Debris. Molecules (Basel, Switzerland). 2023. 28. 18
Shigeki Arai, Rumi Shimizu, Motoyasu Adachi, Mitsuhiro Hirai. Magnetic field effects on the structure and molecular behavior of pigeon iron-sulfur protein. Protein science : a publication of the Protein Society. 2022. 31. 6. e4313
