Okubo Tadashi

オオクボタダシ | Okubo Tadashi

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/10450719

Research field (3)： Developmental biology , Molecular biology , Laboratory animal science

Research keywords (16)：マウス , 発生 , 咽頭弓 , 心臓血管系 , 胸腺 , 感覚神経 , 味蕾 , ゲノム編集 , 転写制御 , 先天性心疾患 , 副甲状腺 , ノックアウト , 体節 , 遺伝子 , 脊椎動物 , 形態形成

Research theme for competitive and other funds (15)：

2023 - 2027 心臓形成におけるGlyr1を介した転写制御機構とRipply3の作用機序解明
2022 - 2025 Peptide LvによるOA疼痛制御機構の解明と疼痛治療シーズの創出
2020 - 2023 M2マクロファージ由来神経ペプチドを介した炎症非依存性腰痛惹起機構の解明
2019 - 2023 咽頭嚢からの胸腺の分離移動を制御するRipply3の機能モチーフと胚葉特異的役割
2019 - 2022 Relationship between infrapatellar fat pad derived neuropeptides and osoteoarthritic pain

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Papers (31)：

Yuji Yokozeki, Kentaro Uchida, Ayumu Kawakubo, Mitsufumi Nakawaki, Tadashi Okubo, Masayuki Miyagi, Gen Inoue, Makoto Itakura, Hiroyuki Sekiguchi, Masashi Takaso. TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model. BMC musculoskeletal disorders. 2021. 22. 1. 634-634
Manabu Mukai, Kentaro Uchida, Tadashi Okubo, Shotaro Takano, Toshihide Matsumoto, Masashi Satoh, Gen Inoue, Masashi Takaso. Regulation of Tumor Necrosis Factor-α by Peptide Lv in Bone Marrow Macrophages and Synovium. Frontiers in medicine. 2021. 8. 702126-702126
Effect of retinoic acid, signaling on Rip, l, expression a, pharyngeal arch morphogenesis in mouse embryos. Effect of retinoic acid signaling on Ripply3 expression and pharyngeal arch morphogenesis in mouse embryos. 2021. 250. 1036-1050
Shintaro Saegusa, Masahiro Fukaya, Wataru Kakegawa, Manabu Tanaka, Osamu Katsumata, Takeyuki Sugawara, Yoshinobu Hara, Makoto Itakura, Tadashi Okubo, Toshiya Sato, et al. Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions. PloS one. 2019. 14. 5. e0216960
Tadashi Okubo, Asako Sato, Hirotsugu Okamoto, Toshiya Sato, Toshikuni Sasaoka. Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages. International Journal of Developmental Neuroscience. 2018. 66. in press. 1-8

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MISC (12)：

齊藤奈英, 板倉誠, 田井中一貴, Macpherson Tom, 疋田貴俊, 山口瞬, 佐藤朝子, 大久保直, 知見聡美, 南部篤, et al. 【ドパミン研究の最近の展開】D1およびD2ドーパミン受容体を介する神経伝達による運動制御と学習記憶の仕組みの理解. 日本生物学的精神医学会誌. 2022. 33. 3. 100-105
相川淳, 内田健太郎, 天野英樹, 大久保直, 佐藤威文, 大貫裕子, 馬嶋正隆, 高相晶士. Gemcitabineは骨破壊抑制非依存性にがん性骨痛を軽減する. 日本整形外科学会雑誌. 2017. 91. 8. S1738-S1738
大久保直. 国立科学博物館企画展「卵からはじまる形づくり」ブックレット. 2017. 37
Tadashi Okubo. Tbx1/Ripply3/retinoic acid signal network that regulates pharyngeal arch development. New Principles in Developmental Processes. 2014. 9784431546344. 97-108
Tadashi Okubo, Shinji Takada. Molecular mechanism of thymus development from the pharyngeal arch. Seikagaku. 2012. 84. 3. 168-176

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Education (1)：

Professional career (1)：

Work history (6)：

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Committee career (1)：

Awards (1)：

Association Membership(s) (4)：

日本ゲノム編集学会 , JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE , The Molecular Biology of Japan , The Japanese Society of Developmental Biologist

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