Rchr

J-GLOBAL ID：200901020274000758 Update date: Apr. 11, 2024

Noguchi Koichi

Affiliation and department：
Job title： Professor & Chair

Research field (3)： Neuroscience - general , Neuroanatomy and physiology , Orthopedics

Research keywords (33)：包括脳ネットワーク , 統合脳・神経回路機能 , 統合脳・神経回路機能班友 , 関節炎 , 接着因子 , 神経損傷 , ペプチド , in situ ハイブリダイゼ-ション , 侵害刺激 , p38 , 神経炎 , 可塑性 , 後索核 , 遺伝子発現 , MAPK , 脊髄損傷 , 末梢神経障害 , L1-CAM , BDNF , mRNA , サブスタンスP , ERK , 痛み , 脊髄後角 , TRPA1 , ラット , DRG , ニューロパチックペイン , NGF , 脊髄 , in situハイブリダイゼ-ション法 , 疼痛 , 後根神経節

Research theme for competitive and other funds (45)：

2022 - 2026 運動器疼痛による情動系脳内ネットワーク変調のゲートキーパー、腕傍核の調節機構
2017 - 2020 Regulation of activation switching in spinal microglia as a tool of treatment of chronic pain
2017 - 2020 Aberrant axo-axonic synaptic reorganization in the calcium channel subunit alpha2 delta-1/L1-CAM-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model
2015 - 2017 New mechanisms of neuropathic pain after spinal cord injury
2015 - 2017 Development of minimally invasive treatment for osteoarthritis using focused ultrasound technique

2014 - 2017 pain modulation by AMP kinase through TRP channels and its molecular mechanism

2013 - 2016 Molecular basis of spinal glia/endothelium/neurons interaction as the mechanisms of development and maintenance of chronic pain

2012 - 2014 Novel regulator of gene expression in DRG in a neuropathic pain

2011 - 2013 脂質メディエーター特にロイコトリエンによる疼痛伝達制御機構

2010 - 2012 Molecular mechanisms of spinal neuro-glial interaction involving neuropathic pain

2009 - 2009 脊髄グリア細胞でのtPA発現を介した脊髄根損傷モデル特異的疼痛メカニズムの証明

2009 - 2009 神経栄養因子によるペインセンサーTRPA1の機能調節機構

2007 - 2009 Molecular mechanisms of neuropathic pain

2007 - 2008 Role of MAP kinase family in the peripheral sensitization in a model of temporomandibular joint pain

2007 - 2008 Contribution of extra-cellular protease, tPA to the radicular pain

2007 - 2008 マルチモーダルセンサーTRPA1の機能調節機構

2006 - 2007 神経栄養因子の発現制御による坐骨神経痛モデルの治療の試み

2006 - 2007 modulation mechanism of transient receptor potential A1 by proteinase activated receptor 2

2006 - 2007 Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain

2006 - 2007 神経因性疼痛における細胞間接着因子L1-CAMの役割

2005 - 2006 Role of inflammation on neuropathic pain in trigeminal nerve

2005 - 2006 Contribution of thermo-sensitive ion channels to pathomechanism of CRPS

2003 - 2006 Signal transduction mechanisms in primary afferent neurons following pain transmission

2005 - 2005 侵害受容神経回路網における細胞間接着因子の役割

2003 - 2004 Mechanisms of ectopic orofacial pain following peripheral nerve injury.

2003 - 2004 深部組織特異的な一次感覚ニューロンの感受性亢進のメカニズム

2001 - 2002 Involvement of immune system to the inferior alveolar nerve injury.

2001 - 2002 神経因性疼痛における非損傷ニューロンの役割

2001 - 2001 根性坐骨神経痛モデルにおける炎症反応と一次知覚ニューロンでの遺伝子発現

2000 - 2001 REGULATION OF GENE EXPRESSION AND NEUROFUNCTION UNDER OROFACIAL PAIN

1999 - 2000 MOLECULAR MECHANISM OF ABNORMAL SENSATION AFTER INJURY OF INFERIOR ALVEOLAR NERVE

1999 - 2000 The mechanism of neuropatic pain model

1998 - 2000 Expression of nerve construction protein in developing and regenerating auditory organ

1998 - 1999 腰部脊柱管狭窄症モデルラットの脊髄における間欠性跛行発症の分子機構

1997 - 1998 損傷脊髄機能再建の為の分子基盤の解明

1996 - 1997 Changes in neuroactive substances in trigeminal motor nucleus after peripheral nerve injury

1996 - 1997 Changes in gene expression in facial nerve nuclei in the rat model of ischemic Bell's palsy

1996 - 1997 脊髄損傷にによる神経ペプチド発現誘導と神経栄養因子による制御機構

1996 - 1997 Dynorphin mRNA expression in dorsal horn neurons following traumatic spinal cord injury and the effect of neurotrophic factor

1995 - 1996 Electron microsopic and histochemical study on the neural circuitry for color vision in the monkey retina

1995 - 1996 Changes in neuroactive substances in a rat model of neuropathic pain and the role of hyperexcitability in neurons of spinal cord-dorsal colum-thalamus pathway

1993 - 1995 The development of viral vector for in vivo gene-delivery and its applications

1992 - 1994 脊髄上行性投射ニュ-ロンにおける痛覚伝達関連物質とその制御機構に関する研究

1992 - 1993 痛みによる内因性活性物質の変化とその分子機構

1991 - 1991 痛みによる内因性活性物質の変化とその分子機構

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Papers (260)：

Masakazu Toi, Tachibana Toshiya, Koichi Noguchi, Hiroki Yamanaka, Kimiko Kobayashi, Masamichi Okubo, Kazuya Kishima, Yi Dai. COX2 expression plays a role in spinal cord injury-induced neuropathic pain. Neuroscience letters. 2024. 823. 137663-137663
Hirosato Kanda, Koichi Noguchi, Yi Dai. Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier. Molecular Brain. 2023
Shaoqi Duan, Nobuko Imamura, Takashi Kondo, Hirosato Kanda, Yoko Kogure, Takuya Okugawa, Masashi Fukushima, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, et al. Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia. Journal of neurogastroenterology and motility. 2022. 28. 2. 255-264
Ayano Saeki, Hiroki Yamanaka, Kimiko Kobayashi, Masamichi Okubo, Koichi Noguchi. Analgesic effect of gastrin-releasing peptide in the dorsal horn. Molecular pain. 2022. 18. 17448069221108965-17448069221108965
Xiaohang Wang, Hirosato, Takeshi Tsujino, Yoko Kogure, Feng Zhu, Satoshi Yamamoto, Taichi Sakaguchi, Koichi Noguchi, Yi Dai. Reactive Oxygen Species Cause Exercise-Induced Angina in a Myocardial Ischaemia-Reperfusion Injury Model. International Journal of Molecular Sciences. 2022

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MISC (179)：

木島和也, 橘俊哉, 圓尾圭史, 有住文博, 楠山一樹, 都井政和, 野口光一. 脊髄損傷後神経障害性疼痛におけるROCKの役割. 日本整形外科学会雑誌. 2021. 95. 2. S124-S124
段韶基, 段韶基, 近藤隆, 神田浩里, 河野友彰, 福島政司, 富田寿彦, 大島忠之, 福井広一, 戴毅, et al. 母子分離ラットの胃知覚過敏と胃十二指腸微小炎症との関連. 日本潰瘍学会プログラム・抄録集. 2021. 48th
野口光一. 疼痛領域各学会の現状・めざす方向性と日本痛み関連学会連合の連携から生まれるもの・期待できるもの日本疼痛学会痛み関連学会連合に期待するもの. PAIN RESEARCH. 2020. 35. 4. 227-227
大久保正道, 山中博樹, 小林希実子, 野口光一. 脊髄後角におけるmGluRの発現解析と炎症性疼痛との関連. PAIN RESEARCH. 2020. 35. 4. 237-237
段韶き, 神田浩里, 近藤隆, 三輪洋人, 野口光一, 戴毅. ラット母子分離ストレスモデルにおける胃十二指腸の微小炎症は胃の痛覚過敏に関与する(Micro-inflammation in the Gastroduodenal Tract Contributes to Gastric Pain Hypersensitivity in MS Model Rats). PAIN RESEARCH. 2020. 35. 4. 259-259

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Work history (9)：

2020 - 現在日本痛み関連学会連合代表
2016 - 現在 Hyogo College of Medicine
2013 - 現在日本疼痛学会理事長
1994 - 現在 Hyogo College of Medicine Faculty of Medicine
1991 - 1994 Wakayama Medical University

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Awards (1)：

2012/11 - 兵庫県兵庫県科学賞

Association Membership(s) (6)：

Society for Neuroscience , International Society for the Study of Pain (IASP) , 日本運動器疼痛学会 , 日本神経科学学会 , 日本解剖学会 , 日本疼痛学会

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