Rchr
J-GLOBAL ID：200901020347156140
Update date: Feb. 01, 2024
Saito Yoshio
サイトウ ヨシオ | Saito Yoshio
Affiliation and department：
Job title：
Professor
Research field (1)：
Biochemistry
Research keywords (4)：
遺伝子診断
, ヌクレオシド
, 核酸化学
, Bioorganic Chemistry
Research theme for competitive and other funds (4)：
- 2019 - 2022 Development of novel environmentally sensitive fluorescent PNA probes
- 2016 - 2019 Development of dual-fluorescent ODN probes for SNPs typing
- 2013 - 2016 Development of pH-responsive fluorescent nucleosides for SNPs detection
- 2011 - 2014 Design of Environmentally Sensitive Fluorescent Nucleosides and Their Application to Innovative Fluorescence Probe for Gene Analysis
Papers (89)：
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Y. Oku, M. Kai, S. Kobayashi, R. Katoh, Y. Saito. Acyclic 2-ethynylnaphthalene-modified 8-aza-3,7-dideaza-2'-deoxyadenosine affords thymine discrimination by probing the DNA minor groove environment. Synlett. 2023. In press
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S. Koboku, T. Tsukada, Y. Oku, S. Kobayashi, Y. Saito. FRET-based dual-labeled oligonucleotide probe detects target DNA by probing a minor groove environment. Org. Biomol. Chem. 2022. 20. 1699-1706
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S. Koboku, M. Yanagi, A. Funato, A. Suzuki, Y. Saito. 2-Ethynylnaphthalene-modified 8-aza-3,7-dideaza-2′-deoxyadenosine derivative discriminates thymine in target DNA via changes in the fluorescence wavelength. Tetrahedron Lett. 2020. 61. 151841
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T. Takeda, M. Yanagi, A. Suzuki, R. Katoh, Y. Saito. Synthesis of ethynylpyrene-modified 3-deaza-2'-deoxyguanosines as environmentally sensitive fluorescent nucleosides: target DNA-sequence detection via changes in the fluorescence wavelength (Selected as a "Front cover"). Tetrahedron Lett. 2019. 60. 825-830
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S. Cho, A. Ghorbani-Choghamarani, Y. Saito, R. H. E. Hudson. 6-Phenylpyrrolocytidine: an intrinsically fluorescent, environmentally responsive nucleoside analogue. Current Protocols in Nucleic Acid Chemistry. 2019. 76. e75
ｍore...
MISC (2)：
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K. Matsumoto, Y. Saito, T. Morii, I. Saito. Design and synthesis of fluorescent oligodeoxyribonucleotides sensitive to the micro environmental change in polarity. The 2nd International Symposium Kyoto University Global COE Program, Uji, 2010.8.19-20. 2010
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齋藤 烈, Y. Saito, Y. Shinohara, S. S. Bag, Y. Takeuchi, K. Matsumsoto, I. Saito. Design of an ultimate quencher free molecular beacon containing pyrrocytidine-guanine base pair. Nucleic Acids Symp. Ser. 2008. 52. 361-362
Patents (12)：
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ウラシルヌクレオシド誘導体、ウラシルヌクレオチド誘導体及びポリヌクレオチド誘導体ならびにそれらを含むプローブ
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3-デアザプリンヌクレオシド誘導体、3-デアザプリンヌクレオチド誘導体及びポリヌクレオチド誘導体
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化合物、プローブ、縮合物及びシトシンの検出方法
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8-アザ-3,7-ジデアザアデニンヌクレオシド誘導体、8-アザ-3,7-ジデアザアデニンヌクレオチド誘導体及びポリヌクレオチド誘導体ならびにプローブ
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ステムループ構造を有する蛍光プローブ
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Books (3)：
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核酸科学ハンドブック(日本核酸化学会) 第II部 25. 遺伝子チップ
講談社 2020 ISBN:9784065207864
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Modified Nucleic Acids (Nucleic Acids and Molecular Biology Vol. 31)
Springer 2016
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ゲノム化学
化学同人 2007
Lectures and oral presentations (190)：
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Design and synthesis of environmentally sensitive fluorescent 7-deaza-2,8-diazaadenosine derivatives
(2022)
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Synthesis and photophysical properties of novel fluorescent DNA probes containing bis- pyrene unit for target DNA detection
(2022)
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Design and synthesis of novel fluorescent DNA probes containing bis-pyrene unit for DNA detection
(2022)
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Synthesis and photophysical properties of novel acyclic ESF nucleoside
(日本化学会第102春季年会 2022)
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Design of novel environmentally sensitive fluorescence nucleosides containing,7-deaza-2,8-diazaadenine skeleton
(日本化学会第102春季年会 2022)
ｍore...
Awards (1)：
Association Membership(s) (5)：
有機合成化学協会
, 日本光医学・光生物学会
, 光化学協会
, 日本化学会
, 日本薬学会
