Aso Teijiro

アソウテイジロウ | Aso Teijiro

Affiliation and department：

Research field (4)： Pathobiochemistry , Neuropathology , Molecular biology , Medical biochemistry

Research keywords (8)： Alzheimer's disease , drug discovery , protein degradation , ubiquitin ligase , RNAポリメラーゼII , Elongin , transcription elongation , regulation of gene expression

Research theme for competitive and other funds (23)：

2022 - 2025 Development of an innovative anti-Alzheimer drug that selectively inhibits the ubiquitination of BRI2 and BRI3
2018 - 2021 BRI2/3-ユビキチンリガーゼを標的とする新規認知症治療薬開発のための基盤研究
2015 - 2018 Identification of Elongin A target genes and clarification of the mechanisms governing conversion of the Elongin complex from its elongation factor to its ubiquitin ligase form
2012 - 2015 In vivo role of transcriptional elongation/ubiquitin ligase factor Elongin
2009 - 2011 Role and mechanism of action of mammalian Elongin A in the stress response

2005 - 2007 Role of transcription elongation factor Elongin on the determination of the cell fate

2005 - 2005 転写伸長因子Elonginの欠失による細胞早期老化の機構の解析

2004 - 2005 転写伸長因子エロンガンの欠失による細胞分裂遅滞の原因の解明

2004 - 2005 Basic Strategy for the treatment of kidney cancer : identification and clinical utilization of new tumor suppressor genes or oncogenes closely correlated with VHL gene VHL

2001 - 2004 Elucidation of the molecular mechanisms of carcinogenesis by the VHL, tumor suppressor gene

2003 - 2003 転写伸長因子エロンガンの細胞増殖制御機能の解析

2002 - 2003 Elucidation in the mechanism of human renal cell carcinoma cancer growth and micrometastasis with inactivation of VHL

2002 - 2003 エロンガン遺伝子欠損マウスを用いた転写伸長相の制御と細胞増殖制御との関連性の解明

2002 - 2002 転写伸長因子エロンガンの機能とVHL発がんとの関連性の解析

2001 - 2002 Transcriptional elongation factor and its implication in human disease

2001 - 2001 VHL癌抑制蛋白の機能喪失による発がんのメカニズムの解析

2000 - 2000 転写伸長制御の破綻に基づく発がんのメカニズムの解明

1997 - 2000 Analysis of gene regulatory function of TFIIF and elongin

1998 - 1998 エロンガンによる転写伸長の制御と発がんとの関連性の解析

1996 - 1998 カルシウム信号を伝達する細胞内調節蛋白質の構造生物学

1997 - 1997 ElonginとVHL癌抑制蛋白による転写調節と細胞の増殖・分化との関連性の解析

1997 - 1997 Elonginのin vivoの機能とVHL癌抑制蛋白による転写制御の機構の解析

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Papers (41)：

Takashi Yasukawa, Aya Tsutsui, Chieri Tomomori-Sato, Shigeo Sato, Anita Saraf, Michael P Washburn, Laurence Florens, Tohru Terada, Kentaro Shimizu, Ronald C Conaway, et al. NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation. Cell reports. 2020. 30. 10. 3478-3491
Juston C Weems, Brian D Slaughter, Jay R Unruh, Stefan Boeing, Shawn M Hall, Merry B McLaird, Takashi Yasukawa, Teijiro Aso, Jesper Q Svejstrup, Joan W Conaway, et al. Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage. The Journal of biological chemistry. 2017. 292. 16. 6431-6437
Juston C Weems, Brian D Slaughter, Jay R Unruh, Shawn M Hall, Merry B McLaird, Joshua M Gilmore, Michael P Washburn, Laurence Florens, Takashi Yasukawa, Teijiro Aso, et al. Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses. The Journal of biological chemistry. 2015. 290. 24. 15030-41
Junya Kawauchi, Makoto Inoue, Mizue Fukuda, Yohei Uchida, Takashi Yasukawa, Ronald C Conaway, Joan W Conaway, Teijiro Aso, Shigetaka Kitajima. Transcriptional properties of mammalian elongin A and its role in stress response. The Journal of biological chemistry. 2013. 288. 34. 24302-15
Takashi Yasukawa, Shachi Bhatt, Tamotsu Takeuchi, Junya Kawauchi, Hidehisa Takahashi, Aya Tsutsui, Takuya Muraoka, Makoto Inoue, Masayuki Tsuda, Shigetaka Kitajima, et al. Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation. Cell reports. 2012. 2. 5. 1129-36

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MISC (13)：

Makoto Inoue, Junya Kawauchi, Mizue Fukuda, Yohei Uchida, Takashi Yasukawa, Ronald Conaway, Joan Conaway, Teijiro Aso, Shigetaka Kitajima. Transcriptional properties of mammalian Elongin A and its role in stress response. FASEB JOURNAL. 2014. 28. 1
Teijiro Aso, Takumi Kamura, Shigetaka Kitajima, Ronald C. Conaway, Joan W. Conaway, Takashi Yasukawa. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. FASEB JOURNAL. 2009. 23
田村賢司, 宮田恵吉, 管原和宣, 麻生悌二郎. 転写症候群:転写装置近傍の因子病. 臨床検査. 2004. 48. 2. 223-231
北嶋繁孝, 麻生悌二郎, 山崎勝久. 転写伸長因子の機能--TF2Fとエロンガン (転写因子の機能--転写制御複合体形成のダイナミクス) -- (転写開始・伸長反応の制御機構). 蛋白質核酸酵素. 2000. 45. 9. 1513-1522
S Kitajima, K Yamazaki, T Aso. [Function of transcriptional elongation factors, TFIIF and elongin in gene regulation]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2000. 45. 9 Suppl. 1513-22

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Education (1)：

- 1986 Kochi Medical School

Professional career (1)：

博士(医学)

Work history (1)：

2001/05 - 現在 Kochi Medical School Department of Functional Genomics Professor

Association Membership(s) (3)：

日本生化学会 , 日本分子生物学会 , 米国生化学分子生物学会

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