Research keywords (5)：
Microtubule
, ATP
, Dynein
, Flagella
, Cilia
Research theme for competitive and other funds (15)：
2022 - 2025 Visualizing the activation of flagellar beating at high-pressure.
2021 - 2024 Revealing the architecture of the central pair complex of cilia by integrated structural approach
2019 - 2022 リズミカルな鞭毛運動を誘起する分子マシナリの力学制御
2015 - 2017 Regulatory mechanism of cilia and flagella motility by the change of axoneme diameter
2014 - 2017 Structure and function of novel minor dyneins
2011 - 2013 Regulation of dynein motor activity through the change of axoneme diameter.
2010 - 2013 Structure and function of novel dyneins localized to the proximal region of cilia and flagella
2007 - 2008 Analysis of the movements of single axonemal dyneins on microtubules visualized using quantum dots
2005 - 2008 Assembly mechanism of the highly regular axonemal structure in cilia and flagella
2004 - 2008 Regulatory mechanism of flagellar oscillation
2003 - 2004 Direct observation of dynein-microtubule binding
2002 - 2003 電気穿孔法による蛍光標識蛋白質の細胞内導入:鞭毛蛋白質動態解析への応用
2001 - 2002 細胞質性ダイニンの微小管結合部位の研究
2000 - 2000 鞭毛によるクラミドモナス細胞の滑走運動の研究
1998 - 1999 鞭毛ダイニン分子の力発生機構の研究
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Papers (70)：
Yusuke Kondo, Tomoka Ogawa, Emiri Kanno, Masafumi Hirono, Takako Kato-Minoura, Ritsu Kamiya, Toshiki Yagi. IC2 participates in the cooperative activation of outer arm dynein densely attached to microtubules. Cell Structure and Function. 2023. 48. 2. 175-185
Toshiki Yagi, Akiyuki Toda, Muneyoshi Ichikawa, Genji Kurisu. Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain. Biophysics and Physicobiology. 2023. 20. 1. n/a-n/a
Toshiki YAGI, Masayoshi NISHIYAMA. Activation of Eukaryotic Flagellar Beating at High-Pressure. The Review of High Pressure Science and Technology. 2021. 31. 2. 66-73
Toshiki YAGI, Akiyuki TODA, Muneyoshi ICHIKAWA, Genji KURISU. The Complex of Outer-arm Dynein Light Chain-1 and the Microtubule-binding Domain of the Heavy Chain Shows How Axonemal Dynein Tunes Ciliary Beating. Seibutsu Butsuri. 2021. 61. 1. 020-022
Cilia: Motors and Regulation: Motors and Regulation: 92 (Methods in Cell Biology)
Academic Press 2009
Lectures and oral presentations (34)：
Chlamydomonas Move-Backwards-Only mutants restored forward swimming by a point mutation in the outer-arm dynein β heavy chain
(The 61th annual meeting of biophysical society of Japan 2023)
A point mutation in intermediate chain 2 disturbs motor activity of outer arm dynein
(Chlamy Conference 2023)
Analysis of flagellar waveform conversion mechanism of Chlamydomonas reinhardtii.
(2023)
FAP47, HYDIN, and CPC1 in the central pair apparatus of Chlamydomonas
(2022)
Cooperative interactions among axonemal dyneins is regulated by the outer-arm dynein intermediate chain
(2022)
