Wakayama Tomohiko

ワカヤマトモヒコ | Wakayama Tomohiko

Affiliation and department：
Job title： Professor

Research field (1)： Anatomy

Research keywords (9)： Electron microscope , 解剖学 , Male infertility , 細胞接着分子 , セルトリ細胞 , 精子形成 , Reproductive biology , Histochemistry , Histology

Research theme for competitive and other funds (30)：

2021 - 2024 A search of novel genes involved in spermatogenesis failure of Down syndrome model mice
2021 - 2024 血清尿酸値を感受する尿酸センサーの同定と生理作用
2018 - 2021 細胞接着分子が制御する細胞小器官の配置と鞭毛形成の分子機構
2018 - 2021 development of scaffold free three dimensional internal thoracic artery from autologous ITA cell
2018 - 2021 development of scaffold free three dimensional contractile cardiac tissue from human stem cell

2017 - 2020 Analysis of the spermatogenic ability in the testis of the cell adhesion molecules defective pigs using the genome editing technology

2016 - 2020 Drug-food interaction on transporters

2015 - 2019 Role of prostaglandin transporter in pulmonary fibrosis and its therapeutic significance

2017 - 2018 細胞接着分子の遺伝子欠損マウスによる異常な精子完成における精子細胞とセルトリ細胞の相互作用に関連する膜性構造物の三次元的構造解析

2014 - 2017 Molecular mechanisms in the hormone-dependent differentiation of the mouse submandibular gland

2013 - 2017 The study of regulatory mechanisms of spermatogenic cell differentiation by cell adhesion molecules

2016 - 2017 精子形成の調節因子である細胞接着分子およびその相互作用する細胞内分子のノックアウトマウスの精巣の形態学的解析

2016 - 2017 精子の形態形成過程における精子細胞とセルトリ細胞間で見られる細胞膜および細胞内膜性構造物の三次元構造解析

2014 - 2016 Local drug-drug interaction of donepezil with cilostazol at BCRP transporter

2013 - 2016 「細胞接着分子による造精細胞の分化調節機構の研究」

2013 - 2015 Transdermal drug delivery targeted to xenobiotics ABC transporters expressed in the skin

2012 - 2015 Investigation of pathophysiological roles of transporter for antioxidant with an aim to develop pharmacotherapeutics of inflammatory organ diseases

2011 - 2013 Roles of the androgen receptor in the sexual differentiation in the mouse submandibular gland

2011 - 2012 Development of triple-target antitumor drugs recognized by oligopeptide transporters

2010 - 2012 Molecular mechanism of cell adhesion molecules involved in testiculargerm cell differentiation.

2008 - 2010 Research of transporter-adaptor network as target of drug effect and toxicity

2008 - 2010 Regulatory role of ezrin on transportsome at the blood placenta barrier

2008 - 2010 Study on the functional mechanisms of androgens in differentiation of the mouse submandibular gland

2007 - 2009 Research of signal transduction by cell adhesion molecules in spermatogenesis

2005 - 2006 GENE EXPRESSION DURING THE DUCT CELL DIFFERENTIATION IN SALIVARY GLANDS

2003 - 2004 The mechanism of androgen-dependent differentiation of the duct system in the submandibular gland

2001 - 2002 The signal-transduction mechanisms of the cell proliferation and differentiation in the submandibular gland

2001 - 2002 新規接着分子の精子発生における機能解析およびそれと相互作用する分子の探索

1999 - 2000 精子鞭毛蛋白質の遺伝子発現、機能解析と新規免疫グロブリンスーパーファミリーの探索

1998 - 1999 微少注入法を利用した精細胞分化のin vivo 実験系の確立と応用

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Papers (107)：

Satoshi Yokota, Tomohiko Wakayama, Hidenobu Miyaso, Kousuke Suga, Masakatsu Fujinoki, Satoru Kaneko, Satoshi Kitajima. Reactive Blue 2 Labels Protamine in Late-Haploid Spermatids and Spermatozoa and Can Be Used for Toxicity Evaluation. Andrologia. 2023. 2023. 1-12
Arunothai Wanta, Kazuhiro Noguchi, Taichi Sugawara, Kayoko Sonoda, Suthat Duangchit, Tomohiko Wakayama. Expression of Protein Markers in Spermatogenic and Supporting Sertoli Cells Affected by High Abdominal Temperature in Cryptorchidism Model Mice. Journal of Histochemistry and Cytochemistry. 2023. 71. 7. 387-408
Satoshi Yokota, Hidenobu Miyaso, Toshinori Hirai, Kousuke Suga, Tomohiko Wakayama, Yuhji Taquahashi, Satoshi Kitajima. Development of a non-invasive method for testicular toxicity evaluation using a novel compact magnetic resonance imaging system. The Journal of toxicological sciences. 2023. 48. 2. 57-64
Tomohiko Wakayama, Satoshi Yokota, Kazuhiro Noguchi, Taichi Sugawara, Kayoko Sonoda, Arunothai Wanta. Correction to: Quantitative evaluation of spermatogenesis by fluorescent histochemistry (Histochemistry and Cell Biology, (2022), 157, 3, (287-295), 10.1007/s00418-022-02080-6). Histochemistry and Cell Biology. 2022. 157. 6. 703
Aya Hasan Alshammari, Yusuke Masuo, Ken-Ichi Fujita, Kazuhiro Shimada, Noriho Iida, Tomohiko Wakayama, Yukio Kato. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition. Biochemical pharmacology. 2022. 197. 114914-114914

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MISC (119)：

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Books (2)：

生殖器
日本医事新報社 2021 ISBN:9784784932450
「Essential解剖学-テキスト&アトラス」
南江堂 2015

Lectures and oral presentations (12)：

SEM連続断面観察法による精子形成における膜構造の三次元微細構造解析
(第123回日本解剖学会総会・全国学術集会 2018)
哺乳類の精巣の精子形成と細胞接着分子Cell adhesion molecule-1の発現と局在
(第49回日本臨床分子形態学会総会・学術集会 2017)
細胞接着分子による精子形成の調節機構
(第57回日本先天異常学会学術集会 2017)
女性生殖器系の組織構造
(第59回日本婦人科腫瘍学会学術講演会 2017)
野生型および細胞接着分子CADM1欠損マウスの精巣におけるCADM1のアダプター蛋白質MPP6の発現と局在
(第73回日本顕微鏡学会学術講演会 2017)

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Education (4)：

- 1998 Kanazawa University
- 1998 Kanazawa University Graduate School, Division of Medicine
- 1994 Kanazawa University
- 1994 Kanazawa University Faculty of Medicine

Professional career (1)：

Doctor (Medicine) (Kanazawa University)

Work history (3)：

2023/04 - 現在熊本大学大学院生命科学研究部附属臨床医学教育研究センター副センター長
2015/04 - Kumamoto University Faculty of Life Sciences
2015 - Professor,Faculty of Life Sciences(Basic medicine group),Kumamoto University

Awards (8)：

2016/09 - 科研費審査委員表彰
2012/07 - 第8回十全医学賞受賞
2011/12 - 日本生殖免疫学会学会賞
2010/07 - 日本アンドロロジー学会学術奨励賞
2008/07 - 日本アンドロロジー学会オルガノ学術奨励賞

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Association Membership(s) (11)：

THE JAPANESE SOCIETY OF MICROSCOPY , THE JAPANESE SOCIETY FOR CLINICAL MOLECULAR MORPHOLOGY , The Histochemical Society , The Society for Reproduction and Fertility , JAPAN SOCIETY FOR IMMUNOLOGY OF REPRODUCTION , JAPAN SOCIETY OF ANDROLOGY , Society for the Study of Reproduction , 日本組織細胞化学会 , 日本解剖学会 , Japan Society of Histochemistry and Cytochemistry , TheJapanese Association of Anatomists

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