Maejima Yuko

マエジマユウコ | Maejima Yuko

Affiliation and department：
Other affiliations (1)：

福島県立医科大学肥満・体内炎症解析講座特任教授

Research theme for competitive and other funds (22)：

2022 - 2025 The study of anti-aging and healthy life expectancy via oxytocin receptors
2021 - 2025 Reveal of the theanine effect in the brain with antidepressant based on derivatization imaging MS.
2018 - 2021 The study of anti-obesity effect by recovery of endogenous oxytocin secretion and its clinical implication
2014 - 2017 Contribution of KATP channel in PVN oxytocin neurons for food intake regulation.
2015 - 2017 幼少期エネルギー環境に適応した室傍核オキシトシン神経回路網の発達・構築機構の解明

2014 - 2015 光による摂食制御:神経回路の解明と生理的・病態的・治療的意義

2012 - 2014 Regulation by Na-K pump of glucose-sensitive NPY neurons and feeding behavior, and its dysfunction in hyperphagia and obesity

2011 - 2014 Regulation by nesfatin and oxytocin of feeding, metabolism and circadian rhythm, as a basis for treating life style-related diseases

2013 - 2014 オキシトシンによる摂食リズム創出神経経路の解明

2012 - 2014 オキシトシン点鼻投与による肥満・メタボリックシンドロームの改善と治療基盤の確立

2012 - 2014 満腹因子Nesfatin-1の食事・中枢時計による制御機構の解明と病態的役割

2012 - 2013 オキシトシンの抗肥満作用の臨床応用基盤

2011 - 2012 末梢オキシトシンによる摂食・代謝調節神経経路の解明と肥満治療

2010 - 2011 Novel function of oxytocin : its anorectic neuronal pathway and(patho) physiological role in regulating feeding

2010 - 2011 末梢経由オキシトシンの摂食調節作用機序の解明と肥満治療応用

2010 - 2011 Nesfatin-1誘導性Oxtによる摂食抑制経路の解明とOxtを用いた肥満治療応用基盤の確立

2010 - 2011 新規満腹因子ネスファチンとオキシトシンの中枢・末梢作用経路と肥満治療展開

2010 - 2011 オキシトシンの摂食抑制機構の解明と肥満治療への応用

2010 - 2011 ネスファチンーオキシトシンーPOMC系による摂食・代謝調節機構の解明

2008 - 2009 Nesfatin-1を介した摂食抑制経路:末梢満腹因子-脳幹-視床下部連関

2006 - 2007 Inputs and outputs of NPY and BDNF neurons in the hypothalamus and their implication in feeding and metabolic regulation

2003 - 2007 Novel signaling function of adipocytes

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Papers (103)：

Shigeki Kitamura, Naoya Murao, Shoko Yokota, Masaru Shimizu, Tomoyuki Ono, Yusuke Seino, Atsushi Suzuki, Yuko Maejima, Kenju Shimomura. Effect of fenofibrate and selective PPARα modulator (SPPARMα), pemafibrate on KATP channel activity and insulin secretion. BMC research notes. 2023. 16. 1. 202-202
Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Yuko Maejima, Shingen Misaka, Kenju Shimomura, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani. C188-9, a specific inhibitor of STAT3 signaling, prevents thermal burn-induced skeletal muscle wasting in mice. Frontiers in Pharmacology. 2022. 13
Yuko Maejima, Shoko Yokota, Tomoyuki Ono, Zhiqian Yu, Megumi Yamachi, Shizu Hidema, Kenneth E Nollet, Katsuhiko Nishimori, Hiroaki Tomita, Hiroyuki Yaginuma, et al. Identification of oxytocin expression in human and murine microglia. Progress in neuro-psychopharmacology & biological psychiatry. 2022. 119. 110600-110600
Yuko Maejima, Shoichiro Horita, Shoko Yokota, Megumi Yamachi, Masaru Shimizu, Tomoyuki Ono, Zhiquian Yu, Hiroaki Tomita, Kenju Shimomura. Surface translocation of Kir2.1 channel induces IL-1β secretion in microglia. Molecular and cellular neurosciences. 2022. 120. 103734-103734
Yuko Maejima, Shoichiro Horita, Shoko Yokota, Tomoyuki Ono, Peter Proks, Hiromi Yoshida-Komiya, Yoichi Ueta, Katsuhiko Nishimori, Shingen Misaka, Kenju Shimomura. Identification of oxytocin receptor activating chemical components from traditional Japanese medicines. Journal of food and drug analysis. 2021. 29. 4. 653-675

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MISC (21)：

Jingmin Zhao, Ryota Imai, Naoyuki Ukon, Saki Shimoyama, Yuko Maejima, Yuji Omiya, Kazuhiro Takahashi, Guangxian Nan, Songji Zhao, Hiroshi Ito, et al. Evaluation of effect of Ninjin'yoeito on regional brain glucose metabolism by F-18-FDG autoradiography with insulin loading in superaged mice. JOURNAL OF NUCLEAR MEDICINE. 2021. 62
趙景敏, 趙景敏, 今井亮太, 今井亮太, 右近直之, 下山彩希, 前島裕子, 大宮雄司, 高橋和弘, 南光賢, et al. ¹⁸F-FDG ARGを用いた超高齢マウスの局所脳糖代謝に対する人参栄養湯の効果評価. 核医学(Web). 2021. 58. Supplement
桂田健一, 桂田健一, 桂田健一, 中田正範, 中田正範, 齋藤俊信, 齋藤俊信, 齋藤俊信, 張博洋, 張博洋, et al. GLP-1受容体作動薬の高血圧改善メカニズム:延髄孤束核カテコラミンニューロン活性化と交感神経活動是正. 糖尿病(Web). 2020. 63. Suppl
前島裕子, 下村建寿. オキシトシンの心と身体における役割. 脳神経内科. 2019. 90. 3. 230-238
The mechanisms of feeding regulation and anti-obesity effect by oxytocin:The clinical implication. 2018. 35. 4

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Books (3)：

最強の医師団が教える長生きできる方法
2020
オキシトシンの中枢神経作用
2014
糖尿病の分子標的と治療薬事典 : 糖尿病・代謝疾患治療薬のターゲット分子と作用機序,薬効のすべて
羊土社 2013 ISBN:9784758120425

Lectures and oral presentations (5)：

Oxytocin and herbal medicine
(日本内分泌学会学術総会ランチョンセミナー 2019)
oxytocin's feeding regulation and anti-obesity effects
(第175回分泌セミナー 2018)
オキシトシンによる摂食制御機構とその慢性効果
(日本農芸化学会東北支部150回大会 2015)
オキシトシンによる摂食制御メカニズムとその慢性効果
(日本動物学会第86回大会 2015)
Paraventricular nucleus oxytocin to arcuate nucleus POMC: a novel anorexigenic neuronal pathway in hypothalamus
(2014)

Professional career (1)：

博士(農学) (東京農工大学)

Work history (2)：

2017/04 - 現在 Fukushima Medical University School of Medicine Department of Bioregulation and Pharmacological Medicine
2014/09 - 2017/03 Fukushima Medical University School of Medicine

Awards (4)：

2022/02 - 福島医学会令和3年福島医学会学術奨励賞
2010 - EASD EASD travel Award
2010 - 自治医科大学自治医科大学最優秀論文賞
2007 - 日本畜産学会日本畜産学会研究奨励賞

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