Rchr
J-GLOBAL ID:200901021244669420
Update date: Apr. 24, 2024
Fujiwara Toshiyoshi
フジワラ トシヨシ | Fujiwara Toshiyoshi
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www.ges-okayama-u.com/
Research field (3):
Digestive surgery
, Tumor diagnostics and therapeutics
, Biomedical engineering
Research keywords (6):
遺伝子治療
, 腫瘍外科
, 消化器外科
, Gene Theuapy
, Surgical Oncology
, Gastroenterological Surgery
Research theme for competitive and other funds (45):
- 2022 - 2025 Immune molecular mechanism for enhancing antitumor potency of a next-generation oncolytic virus by pre-immunization
- 2022 - 2025 胆管癌のmolecular subtype分類の構築
- 2020 - 2023 Non-clinical study of wild-type p53-expressing armed adenovirus for refractory cancer
- 2019 - 2022 Development of a next-generation viral agent targeting immunosuppression by crosstalk in the pancreatic cancer microenvironment
- 2019 - 2022 Development of boron neutron capture therapy targeting gastrointestinal cancer and search for biomarkers of its efficacy
- 2019 - 2022 Practical classification of molecular subtype of intrahepatic cholangiocarcinoma including liquid biopsy
- 2016 - 2019 Development of the Dual fluorescent cytology with tumor-specific viruses for gastrointestinal cancer precision medicine
- 2016 - 2019 Detection of Circulating MicroRNAs with Ago2 Complexes to Monitor the Tumor Dynamics of Colorectal Liver Metastasis Patients during Chemotherapy
- 2015 - 2018 Preclinical analysis of oncolytic adenovirus infection to patient-derived tumor specimens of bone and soft tissue tumors
- 2015 - 2018 Development of novel treatment strategy against bone and soft tissue sarcoma by combination of tumor-specific oncolytic adenovirus and radiotherapy
- 2015 - 2018 Development of oncolytic virotherapy against both cancer cells and cancer-associated fibroblasts
- 2015 - 2017 Analysis for intraperitoneal cancer microenvironment to elucidate the biological mechanism of peritoneal metastasis of gastrointestinal cancer
- 2014 - 2016 Novel targeting therapy to cancer-associated fibroblasts for treatment-resistant carcinomas
- 2013 - 2016 "Cell-in-cell" activity-based tumor-specific delivery of biologics
- 2013 - 2016 p53-expressing oncolytic adenovirus enhances the anti-tumor effect of chemotherapy and radiotherapy
- 2013 - 2016 Therapeutic potential of circulating tumor microenvironment based on metastatic mechanism
- 2013 - 2016 Photoimmunotherapy for gastrointestinal cancer
- 2013 - 2016 Novel treatment strategy for colorectal cancer based on genetic/ epigenetic information
- 2013 - 2015 Fluorescent virus-guided capturing of epithelial-mesenchymal transition (EMT)-induced circulating tumor cells (CTCs) for genetic analysis
- 2012 - 2015 Establishment of 4th generation of islet isolation and the clinical application
- 2011 - 2015 Development of an efficient gene expression vector utilizing RNA-binding proteins and antisense transcripts
- 2011 - 2014 Establishment of non-invasive cancer screening paradigm
- 2011 - 2013 Fluorescence-guided detection and genetic analysis of circulating tumor cells
- 2011 - 2013 Tumor suppressor FHIT regulates tumor invasion of pancreatic cancer cells via inhibiting association of Ezrin and Actin cytoskeleton
- 2011 - 2012 Circulating Tumor Cell of Gastrointestinal Stromal Tumor
- 2010 - 2012 Molecular therapy for gastric cancer using HER2-extracellular domain-expressing adenovirus
- 2010 - 2012 Circulating tumor cell-based tailor-made therapy for hepatocellular carcinoma
- 2010 - 2012 Development of new diagnostic methods for bladder cancer using GFP expressing adenovirus vector
- 2008 - 2010 Development of an adenovirus vector containing microRNA-regulated gene expression system
- 2008 - 2009 進行食道癌に対するテロメラーゼ活性を標的とする新規アデノウイルス製剤の創薬研究
- 2007 - 2008 Telomerase-specific virotherapy for malignant mesothelioma
- 2007 - 2008 Telomerase specific oncolytic virotherapy to purge lymph node metastasis for minimizing invasiveness of gastrointestinal surgery
- 2006 - 2008 The development study of the new gene therapy that assumed telomerase activity for urinary cancers.
- 2005 - 2006 Telomerase-specific fluorescent navigation system for lung cancer surgery
- 2005 - 2006 Development of immortalized allogenic dendritic cells expressing telomerase for treatment of gastroenterological cancer
- 2004 - 2005 Development of cell therapies using reversibly immortalized human pancreatic beta cell lines
- 2003 - 2005 DEVELOPMENT OF TAILORED-MADE TYPE PROSTATE CANCER GENE THERAPY AIMING AT SYSTEMIC IMMUNE-ACTIVATION
- 2003 - 2004 Molecular Fluorescent Imaging of Metastatic Tumors with Conditionally Replication-Selective Adenovirus and GFP Gene
- 2003 - 2003 テロメラーゼ活性を標的とした新規ウイルス療法の開発と化学療法との相互作用の解明
- 2001 - 2002 Molecular Analysis of Resistance to p53 Gene Therapy in Human Lung Cancer
- 2001 - 2001 臨床応用可能なウイルスベクター製造のための企画調査
- 1999 - 2000 Development of Gene Therapy for Lung Cancer using a Novel Antiangiogenic Factor BAI1
- 1997 - 1998 Development of Differentiation-directed Cancer Gene Therapy with p21
- 1996 - 1997 Basic and Clinical Research of p53 Gene Therapy for Human Cancer
- 1995 - 1996 Gene Therapy for Colon Cancer with Adenoviral Vector Expressing Tumor Suppressor p53 Gene
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Papers (1,352):
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Masaaki Akai, Kazuhiro Noma, Takuya Kato, Seitaro Nishimura, Hijiri Matsumoto, Kento Kawasaki, Tomoyoshi Kunitomo, Teruki Kobayashi, Noriyuki Nishiwaki, Hajime Kashima, et al. Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity. British journal of cancer. 2024
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Satoru Kikuchi, Takashi Matsusaki, Toshiharu Mitsuhashi, Shinji Kuroda, Hajime Kashima, Nobuo Takata, Ema Mitsui, Yoshihiko Kakiuchi, Kazuhiro Noma, Yuzo Umeda, et al. Epidural versus patient-controlled intravenous analgesia on pain relief and recovery after laparoscopic gastrectomy for gastric cancer: randomized clinical trial. BJS open. 2024. 8. 1
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Kazuya Yasui, Toshiaki Toshima, Ryo Inada, Yuzo Umeda, Shuya Yano, Hiroaki Tanioka, Akihiro Nyuya, Toshiyoshi Fujiwara, Takeshi Yamada, Yoshio Naomoto, et al. Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles. Molecular cancer. 2024. 23. 1. 1-1
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Koji Uotani, Hiroshi Tazawa, Joe Hasei, Tomohiro Fujiwara, Aki Yoshida, Yasuaki Yamakawa, Toshinori Omori, Kazuhisa Sugiu, Tadashi Komatsubara, Hiroya Kondo, et al. Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus. PloS one. 2024. 19. 2. e0298292
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Kosei Takagi, Tomokazu Fuji, Kazuya Yasui, Yuzo Umeda, Toshiyoshi Fujiwara. ASO Author Reflections: The Role of Robotic Surgery in Patients with Portal Annular Pancreas. Annals of surgical oncology. 2023
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MISC (943):
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重安邦俊, 香川俊輔, 寺石文則, 楳田祐三, 岡田尚大, 半澤俊哉, 橋本将志, 垣内慶彦, 松三雄騎, 菊地覚次, et al. 岡山大学消化器外科の大腸がん診療におけるがんゲノムプロファイリング検査の活用. 日本遺伝性腫瘍学会学術集会プログラム・抄録集. 2023. 29th
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野間和広, 野間和広, 田邊俊介, 田邊俊介, 藤原俊義, 藤原俊義, 藤原俊義. Esophageal reconstruction with free jejunal flap. 消化器外科. 2023. 46. 2
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寺石文則, 寺石文則, 中村峻輔, 高橋一剛, 武田正, 垣内慶彦, 重安邦俊, 重安邦俊, 近藤喜太, 黒田新士, et al. 当施設におけるロボット支援下直腸手術の導入と短期治療成績. 日本ロボット外科学会学術集会プログラム・抄録集. 2022. 14th
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重安邦俊, 矢野修也, 武田正, 山崎泰史, 河内麻里子, 平沢晃, 香川俊輔, 藤原俊義. ペムブロリズマブ使用中に下垂体機能低下症と間質性肺炎を発症したが診療科横断的に加療できた高頻度マイクロサテライト不安定性大腸癌の1例. 日本臨床腫瘍学会学術集会(CD-ROM). 2022. 19th
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菊地覚次, 高田暢夫, 黒田新士, 田辺俊介, 前田直見, 賀島肇, 垣内慶彦, 野間和広, 香川俊輔, 高橋絢子, et al. 患者参加型継続的栄養指導による胃癌術後のサルコペニア予防効果. 日本癌治療学会学術集会(Web). 2022. 60th
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Patents (5):
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腫瘍細胞において選択的に増殖する腫瘍融解ウイルス
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Methods and compositions comprising DNA damaging agents and p53
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Methods and compositions comprising DNA damaging agents and p53
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テロメライシン-GFP遺伝子含有組換えウイルス
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テロメライシン併用抗癌剤
Books (45):
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希少がん:がん診療の新たな課題
日本臨床社 2021
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よくわかるがん免疫療法ガイドブック
金原出版 2020
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入門 腫瘍内科学(改訂第3版)
南江堂 2020
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分子細胞治療フロンティア2020
飯田橋パピルス 2020
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消化器外科専門医の心得
一般社団法人 日本消化器外科学会 2020
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Lectures and oral presentations (2,412):
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岡山大学肝移植と肝胆膵外科の歩み
(第49回岡山大学外科肝胆膵研究会 2022)
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胆道癌に対する外科治療Up to date
(第17回五国胆膵画像診断研究会 2022)
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若手医師による症例提示
(SCSセミナー 2022)
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ここまで挑む!化学放射線療法後の局所進行食道癌の根治手術
(頭頚部手術の最前線2022Winter 2022)
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胃癌術後 1 年目に局所リンパ節再発を疑った腹腔内デスモイド腫瘍の 1 例
(第35回日本内視鏡外科学会総会 2022)
more...
Education (4):
- - 1990 Okayama University
- - 1990 Okayama University Graduate School, Division of Medicine Surgery
- - 1985 Okayama University Medical School Faculty of Medicine
- - 1985 Okayama University Faculty of Medicine
Professional career (1):
- Doctor(medicive) (Okayama University)
Work history (5):
- 2010 - - 岡山大学医歯薬学総合研究科 教授
- 2010 - - Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
- 1991 - 1993 テキサス大学MDアンダーソン癌センター 研究員
- 1991 - 1993 Researcher,The University of Texas M. D. Anderson Cancer Center
- 1985 - 1987 岡山済生会総合病院 未設定
Committee career (12):
- 2011 - 2017 日本癌治療学会 理事
- 2015 - 日本消化器外科学会 評議員
- 2014 - 日本外科学会 理事
- 2012 - 日本がん治療認定医機構 理事
- 2007 - 2011 日本遺伝子治療学会 理事
- 2011 - 日本外科学会 代議員
- 2009 - 日本胃癌学会 評議員
- 2009 - 日本癌治療学会 代議員
- 2007 - 2008 独立行政法人新エネルギー・産業技術総合開発機構(NEDO) 技術委員
- 2006 - 日本癌学会 評議員
- 2001 - 日本再生医療学会 評議員
- 1998 - 日本遺伝子治療学会 評議員
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Awards (6):
Association Membership(s) (11):
日本呼吸器外科学会
, 独立行政法人新エネルギー・産業技術総合開発機構(NEDO)
, 日本ヒト細胞学会
, 日本再生医療学会
, 日本胃癌学会
, 日本がん治療認定医機構
, 日本遺伝子治療学会
, 日本癌学会
, 日本消化器外科学会
, 日本癌治療学会
, 日本外科学会
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