Tsukahara Tamotsu

ツカハラタモツ | Tsukahara Tamotsu

Affiliation and department：
Homepage URL (1)： https://nrid.nii.ac.jp/ja/nrid/1000000529943/

Research field (5)： Nanobioscience , Pharmacology , Pharmaceuticals - chemistry and drug development , Cell biology , Neuroscience - general

Research keywords (6)：酸化ストレス , 炎症 , 認知症 , リゾリン脂質 , 生理活性脂質 , 核内受容体

Research theme for competitive and other funds (20)：

Show all

Papers (81)：

Tamotsu Tsukahara, Shigeyuki Imamura, Toshiro Morohoshi. A Review of Cyclic Phosphatidic Acid and Other Potential Therapeutic Targets for Treating Osteoarthritis. Biomedicines. 2023
Cyclic Phosphatidic Acid for Treating Osteoarthritis. Encyclopedia. 2023
Tamotsu Tsukahara, Masanori Sasaki, Hisao Haniu, Yoshikazu Matsuda. Lysophospholipids transport across blood-brain barrier in an in vitro reconstruction model. Biochemical and Biophysical Research Communications. 2023. 676. 91-96
Masaki Yoshii, Shigeyuki Imamura, Toshiro Morohoshi, Tamotsu Tsukahara. Effects of 2-carba-cyclic phosphatidic acid derivatives on IL-1β-stimulated human chondrocytes. Prostaglandins & Other Lipid Mediators. 2023. 164. 106699-106699
Tatsuya Karaki, Hisao Haniu, Yoshikazu Matsuda, Tamotsu Tsukahara. Lysophospholipids: A Potential Drug Candidates for Neurodegenerative Disorders. Biomedicines. 2022. 10. 12. 3126

ｍore...

MISC (7)：

Tamotsu Tsukahara, Kimiko Murakami-Murofushi. Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor gamma. FASEB JOURNAL. 2011. 25
Ryoko Tsukahara, Tamotsu Tsukahara, Yuko Fujiwara, Junming Yue, Yunhui Cheng, Huazhang Guo, Alyssa Bolen, Chunxiang Zhang, Louisa Balazs, Fabio Re, et al. The PLD2 Product Cyclic Phosphatidic Acid Is a Novel Lipid Second Messenger that Inhibits the Nuclear Hormone Receptor PPAR gamma. FASEB JOURNAL. 2011. 25
Alyssa Lynn Bolen, Anjapravanda P. Naren, Daniel L. Baker, Sarka Beranova-Giorgianni, Michael D. Best, Meng M. Rowland, Derek D. Norman, Li Chen, Sunitha Yarlagadda, Takemitsu Sano, et al. The Phospholipase A1 Activity of Acyl-Protein Thioesterase Links Platelet Activation to LPA Production During Blood Clotting. FASEB JOURNAL. 2011. 25
Tamotsu Tsukahara. Cyclic phosphatidate is a second messenger that negatively regulates the nuclear hormone receptor PPAR gamma. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2008. 28. 6. E98-E98
Gabor Tigyi, Yunhui Cheng, Tamotsu Tsukahara, Chunxiang Zhang, Louisa Balazs. PPAR gamma 1 but not LPA1 and LPA2 GPCR are required for neointima formation induced by lysophosphatidic acid and rosiglitazone in mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2008. 28. 6. E85-E85

ｍore...

Patents (3)：

神経機能再生促進剤
α-シヌクレインの凝集抑制剤、シヌクレオパチーの治療または予防剤、アミロイド形成疾患の治療または予防剤
Novel inhibitors of the Peroxisomes proliferators activated receptor gamma and production thereof. USA

Lectures and oral presentations (35)：

Pharmacological effects of bioactive phospholipids on cellular dysfunction caused by seed-dependent alpha-synuclein aggregation
(2023)
豚肝臓分解物に由来する脂質画分の用量依存的な神経傷害因子放出抑制作用
(日本薬学会第143年会 (札幌) 2023)
豚肝臓分解物に由来する脂質画分の添加時期に依存した神経傷害因子放出抑制作用
(日本薬学会第143年会 (札幌) 2023)
Neurofunctional phospholipids for inhibition of α-synuclein aggregation
(第96回日本薬理学会年会 (横浜) 2022)
Effects of 2-carba-cyclic phosphatidic acid derivatives on IL-1β-stimulated human chondrocytes
(第96回日本薬理学会年会 (横浜) 2022)

ｍore...

Education (1)：

Professional career (1)：

Work history (7)：

Show all

Committee career (6)：

Show all

Awards (12)：

2023/11 - Nagasaki University 2023 Impact Paper Award Lysophospholipids-potent candidates for brain food, protects neuronal cells against α-Synuclein aggregation
2023/07 - 公益財団法人伊藤記念財団研究受賞助成
2018/06 - 公益財団法人伊藤記念財団研究助成受賞
2016/11 - 公益財団法人先進医薬研究振興財団循環医学分野研究助成
2016/11 - タケダ・リサーチサポート

Show all

Association Membership(s) (3)：

Japanese Cytokine Society , THE JAPANESE PHARMACOLOGICAL SOCIETY , 日本脂質生化学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page