Research theme for competitive and other funds (38)：
2022 - 2025 Elucidation of the mechanism of exercise-induced acute kidney injury associated with renal hypouricemia type 1 model mice
2018 - 2022 Sutudy for substances responsible for renal failure death in xanthine oxidoreductase knockout mice
2017 - 2020 Generation of human urate metabolism complete model mice by suppressing xanthine dehydrogenase expression
2014 - 2017 Analysis of genes influencing serum urate levels
2014 - 2017 Studies on androgenic and angiotensin system inhibitors for inhibiting the progression of chronic kidney disease
2013 - 2016 Development of a novel experimental evaluation method for predicting the drug delivery to the brain in human
2014 - 2016 Elucidation of environmental factors involved in the onset of hyperuricemia using complete model animals of human uric acid metabolism
2011 - 2013 Identification and analysis of genes influencing serum uric acid levels
2011 - 2013 Elucidation of the pathogenic mechanism of hyperuricemia in obesity and metabolic syndrome
2008 - 2010 Elucidation of mechanism for exercise-induced acute renal failure in urate transporter deficient mice
2008 - 2010 Production of disease model mice for the drug screening of familial juvenile hyperuricemic nephropathy
2005 - 2007 Genetic analysis for uric acid handling in the kidney
2005 - 2007 Analysis of the mechanism of cadmium nephropathy based on, cadmium kinetics
2005 - 2007 Analysis of the onset mechanism of acute renal failure post exercise using urate transporter knockout mice
2003 - 2004 Study of drug transport mechanism by renal organicion transporters and their clinical significance
2002 - 2004 Genetic analysis for mechanism of underexcretion type hyperuricemia
2002 - 2004 Protein analysis of steroid resistant congenital nephrotic syndrome gene: podocin
2002 - 2004 Development of novel anti-uricosuric agents based on the genomic strategy.
2001 - 2004 Genetic Abnormality of Renal Proximal Tubule-Specific Transporters as Causes of Sudden Death Syndrome in South-Eastern Asia
2001 - 2002 ヒト有機アニオントランスポーターhOAT1におけるプロモーター解析
2000 - 2002 Identification of transporter genes regulating systemic kinetics of drugs and foreign compounds and their genetic polymorphism
1999 - 2001 Molecular mechanisms of drug transport across cell membrane
1999 - 2001 FUNCTIONAL ANALYSIS OF THE ANIONIC DRUG TRANSPORTERS USING KNOCKOUT MICE
1999 - 2001 Cloning of transporters for anionic drugs and the application to pharmacokinetic analysis
1999 - 2000 ヒト尿酸トフンスポーター遺伝子のクローニングと機能解析
1998 - 2000 Development of artificial kidney hybridized with human organic anion transporter expressed cells
1998 - 1999 鼻粘膜薬物吸収におけるトランスポーターの役割に関する研究
1998 - 1999 ISOLATION AND ANALYSIS OF URATE TRANSPORTER OF HUMAN PROXIMAL TUBULE
1997 - 1999 Molecular cloning and functional expression of kidney-specific organic anionic drug transporters
1997 - 1998 New roprorective roles of amino acid transporrers
1997 - 1998 腎特異性グルタミン酸トランスポーターの遺伝子クローニングと機能特性
1996 - 1998 The study toward the development of specific agonist and antagonist for the purinergic receptors in the kidney
1997 - 1997 有機アニオン輸送の細胞内分子機序
1995 - 1997 腎毒性予測法の開発
1997 - 腎での尿酸輸送
1997 - Renal urate handling
1987 - 蛋白尿の病態生理
1987 - Pathophysiology of proteinuria
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Papers (119)：
Masaru Doshi, Yujin Natori, Akira Ishii, Daisuke Saigusa, Shiro Watanabe, Makoto Hosoyamada, Yutaka Hirashima-Akae. Hypothermia increases adenosine monophosphate and xanthosine monophosphate levels in the mouse hippocampus, preventing their reduction by global cerebral ischemia. Scientific reports. 2024. 14. 1. 3187-3187
Yu Toyoda, Hiroshi Miyata, Naohiro Uchida, Keito Morimoto, Ryuichiro Shigesawa, Hidetoshi Kassai, Kazuki Nakao, Naoko H Tomioka, Hirotaka Matsuo, Kimiyoshi Ichida, et al. Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations. Pflugers Archiv : European journal of physiology. 2023
Hisayo Yamaoka, Keiko Yamaoka, Shigekazu Watanabe, Hideyuki Tanaka, Makoto Hosoyamada, Yuzo Komuro. Lactose Stabilization Prolongs In Vivo Retention of Cross-linked Fish Collagen Subcutaneous Grafts in Nude Mice. Plastic and reconstructive surgery. Global open. 2022. 10. 10. e4601
Takuji Hosoya, Shunya Uchida, Shigeru Shibata, Naoko H Tomioka, Koji Matsumoto, Makoto Hosoyamada. Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice. Journal of the American Society of Nephrology : JASN. 2022. 33. 2. 326-341
道志勝, 渡辺志朗, 名取雄人, 細山田真, 赤江豊. Triiodothyronine aggravates delayed neuronal death caused by transient cerebral ischemia in mice. 日本薬学会年会要旨集(Web). 2021. 141st
道志勝, 渡辺志朗, 名取雄人, 細山田真, 赤江豊. Effect of thyroid hormone on occurrence of neuronal death following cerebral ischemia-reperfusion in mice. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
Potassium-Retaining Diuretics : Aldosteron antagonists. In Diuretics : Handbook of Experimental Pharmacology. (共著)
Greger RF. Knauf H. Mutschler E. Springer 1995
Education (2)：
1992 - 1996 The University of Tokyo Post-graduate School of Medicine
- 1990 The University of Tokyo Faculty of Medicine School of Medicine
Professional career (1)：
PhD. (The University of Tokyo)
Work history (6)：
2011 - 現在 Teikyo University Faculty of Pharma-Science Professor
2008 - 2011 Keio University Faculty of Pharmacy Associate Professor
2007 - 2008 Kyoritsu University of Pharmacy Associate Professor
2005 - 2007 Kyoritsu University of Pharmacy Associate Professor
2001 - 2005 Kyorin University Faculty of Medicine Lecturer
1996 - 2001 Kyorin University Faculty of Medicine Assistant Professor
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Committee career (2)：
2002 - 2005 The Japanese Pharmacological Society councilman
2003 - Japanese Society of Gout and Nucleic Acid metabolism councilman
Awards (1)：
2017/02 - 日本痛風·核酸代謝学会 日本痛風・核酸代謝学会賞
Association Membership(s) (8)：
THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, 日本痛風・核酸代謝学会
, 日本薬理学会
, 日本腎臓学会
, The Japanese Society of Nephrology
, Japanese Society of Gout and Nucleic Acid metabolism
, The Japanese Pharmacological Society
