Rchr
J-GLOBAL ID：200901022198116310
Update date: Jan. 31, 2024
Nagai Takayuki
ナガイ タカユキ | Nagai Takayuki
Affiliation and department：
Job title：
Associate Professor
Other affiliations (1)：
Research field (3)：
Internal medicine - General
, Pharmaceuticals - chemistry and drug development
, Pharmaceuticals - health and biochemistry
Research keywords (5)：
antidepressant
, airway inflammation
, influenza vaccine
, anti-influenza virus agent
, Kampo (Japanese herbal) medicines
Research theme for competitive and other funds (14)：
- 2020 - 2023 Mechanism of host-mediated anti-influenza virus activity of a Kampo medicine and its active ingredients
- 2017 - 2020 Proteomic analysis of the mode of action of antidepressive-like effect of a Kampo (traditional Japanese) medicine "kososan" extract.
- 2015 - 2018 Elucidation of immunoabnormality on plumonary mucosal immune system of streptozotocin-induced type I diabetes mice model and analysis of improving effect of Hachimigan
- 2014 - 2017 Study of stress-related disorder monitored by plasma proteomics
- 2014 - 2017 Host-mediated anti-influenza virus activity and action mechanism of a Kampo (traditional Japanese herbal) medicine "shakakusan"
- 2011 - 2013 Action mechanism of Ephedra Herb drug group against influenza virus infection
- 2011 - 2012 Role of orexinergic system in the mechanism underlying an antidepressant-like effect of kososan
- 2009 - 2011 Study on clarification of action mechanism of a Kampo medicine, Hochuekkito through immunomodulating exosome
- 2009 - 2010 Involvement of orexin-A and neuropeptide Y in the antidepressant-like effect of kososan.
- 2008 - 2010 ACTION MECHANISM OF A KAMPO MEDICINE "MAOTO" AGAINST INFLUENZA VIRUS INFECTION
- 2007 - 2008 A possible mechanism underlying an antidepressive-like effect of kososan -A association of orexin-A with neurogenesis-
- 2005 - 2007 ACTION MECHANISM OF A KAMPO MEDICINE "SHOSEIRYUTO" AGAINST AIRWAY INFECTION AND ITS ACTIVE SUBSTANCE
- 2004 - 2006 The comprehensive study on the modulation of airway mucosal immune system by hochuekkito
- 2002 - 2004 Clarification of oligosaccharides for modulation of common mucosal immune system by using formation of artificial oligosaccharide clusters
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Papers (75)：
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Takuya Maeda, Haruna Hosaka, Yuki Nakamura, Shuuji Mawaribuchi, Takayuki Nagai, Mari Endo, Naoki Ito, Hiroaki Kiyohara. Fibroblastic reticular cells and type 3 innate lymphoid cells in <scp>Peyer</scp> ’s patches: Target cell candidates for inulooligosaccharides in hochuekkito formula containing <scp>Atractylodis</scp> rhizoma. Traditional & Kampo Medicine. 2022. 9. 1. 32-40
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Naoki Ito, Akiko Maruko, Kenshiro Oshima, Masaaki Yoshida, Kengo Honma, Chika Sugiyama, Takayuki Nagai, Yoshinori Kobayashi, Hiroshi Odaguchi, Norihiro Okada. Kampo formulas alleviate aging-related emotional disturbances and neuroinflammation in male senescence-accelerated mouse prone 8 mice. Aging. 2022. 14. 1. 109-142
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Naoki Ito, Kazunori Sasaki, Eiji Hirose, Takayuki Nagai, Hiroko Isoda, Hiroshi Odaguchi. Preventive effect of a Kampo medicine, kososan, on recurrent depression in a mouse model of repeated social defeat stress. Gene. 2022. 806. 145920-145920
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Tatsuya Shirahata, Rintaro Miyaishi, Tatsuki Kitazoe, Masaya Saito, Yuki Taneoka, Shuhei Hidaka, Masaki Yokoyama, Takayori Tojima, Tatsuya Katsumi, Nozomu Hirata, et al. Preparation of Tenuifolin from Polygala senega L. Root Using a Hydrolytic Continuous Flow System under High-Temperature, High-Pressure Conditions. The Journal of Organic Chemistry. 2021. 86. 23. 16268-16277
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Liufang Hu, Xiaojun Song, Takayuki Nagai, Marina Yamamoto, Yi Dai, Liangliang He, Hiroaki Kiyohara, Xinsheng Yao, Zhihong Yao. Chemical profile of Cimicifuga heracleifolia Kom. And immunomodulatory effect of its representative bioavailable component, cimigenoside on Poly(I:C)-induced airway inflammation. Journal of Ethnopharmacology. 2021. 267. 113615-113615
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MISC (31)：
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山田陽城, 清原寛章, 永井隆之. パチュリでインフルエンザ対策. aromatopia. 2012. 21. 2. 18-21
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Nagai T, Takata M, Shimizu Y, Nakao M, Matsuki EM, Yamada H. Analysis of the Pharmaceutical Mechanism of a Kampo (Japanese Herbal) Medicine 'Shoseiryuto (Xiao-Qing-Long-Tang)' against Bronchial Asthma with Airway Inflammation in a Mouse Model-Comparion with Steroid. Kampo and Immuno-allergy. 2011. 24. 85-103
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山田陽城, 清原寛章, 松本 司, 永井隆之. Kampo medicine and immunity. 小児科診療. 2010. 73. 3. 387-391
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永井隆之, 蓮見菜月, 橋本良子, 伊藤直樹, 矢部武士, 小寺義男, 大石正道, 前田忠計, 花輪壽彦, 山田陽城. 漢方薬の薬効解析へのプロテオミクスの応用:香蘇散の抗うつ様作用に関わる生体内タンパク質の探索. Clinical Proteomics in Chiba 2008. 2009. 17-22
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Hiroaki Kiyohara, Toshiake Matsuzaki, Tsukasa Matsumoto, Takayuki Nagai, Haruki Yamada. Elucidation of structures and functions through Peyer's patches of responsible carbohydrate chains in intestinal immune system modulating polysaccharides from Japanese medicinal herbs. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN. 2008. 128. 5. 709-716
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Patents (3)：
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Saponin-containing vaccine preparation
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Saponin-containing vaccine preparation
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シアリダーゼ阻害剤
Books (4)：
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薬学生のための漢方医薬学(改訂第3版)
南江堂 2017 ISBN:9784524403363
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Probiotics : immunobiotics and immunogenics
CRC Press 2013 ISBN:9781482206845
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薬学生のための漢方医薬学(改訂第2版)
南江堂 2012 ISBN:9784524402915
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薬学生のための漢方医薬学
南江堂 2007 ISBN:9784524402144
Lectures and oral presentations (211)：
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漢方処方の呼吸器ウイルス感染症に対する効果 補中益気湯、葛根湯・小柴胡湯加桔梗石膏合剤の基礎研究
(第38回和漢医薬学会学術大会 2021)
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中鎖長イヌロオリゴ糖のパイエル板ストローマ細胞に対する調節作用の解析
(第38回和漢医薬学会学術大会 2021)
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Poly(I:C)誘発肺炎症に対する葛根湯および小柴胡湯加桔梗石膏の医療用エキス合剤の作用の解析
(第38回和漢医薬学会学術大会 2021)
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「補中益気湯」のウイルス性呼吸器感染症に対する感染予防作用とその作用メカニズムの検討
(第38回和漢医薬学会学術大会 2021)
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中鎖長イヌロオリゴ糖のLPS誘発sickness behaviorモデルマウスのうつ様行動及び脳内炎症に対する作用の解析
(第38回和漢医薬学会学術大会 2021)
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Works (11)：
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乳酸菌IWF50株が産生するパイエル板免疫機能調節多糖の解析
佐藤仁一, 笠井宏朗, 関口 毅, 永井隆之, 清原寛章 2017 - 2017
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Clarification of modulating activity of Japanese traditional herbal formula, Hochuekkito, on mucosal immune system
Kiyohara H, Idehara M, Ideno S, Matsui H, Nagai T, Hanawa T, Odaguchi H 2017 - 2017
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漢方薬の効き目はどこまで解明されているか?-インフルエンザと抑うつに対する基礎研究から-
永井隆之 2017 - 2017
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漢方方剤「香蘇散」煎剤及び慢性社会的敗北ストレスの免疫系に対する作用の解析
廣瀬栄治, 伊藤直樹, 永井隆之, 及川哲郎, 小田口 浩, 清原寛章 2016 - 2016
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漢方方剤「補中益気湯」からの制御性免疫系を発動するオリゴ糖の探索
安田綾乃, 関谷路子, 丸山弘子, 永井隆之, 清原寛章 2015 - 2015
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Education (2)：
- 1982 - 1984 Kitasato University Graduate School of Pharmaceutical Sciences
- 1978 - 1982 Kitasato University Faculty of Pharmaceutical Science 薬学科
Professional career (6)：
- Ph.D. in Pharmaceutical Sciences (Kitasato University)
- 博士(薬学) (北里大学)
- M.S. in Pharmaceutical Sciences (Kitasato University)
- 薬学修士 (北里大学)
- B.S. in Pharmaceutical Sciences (Kitasato University)
- 薬学士 (北里大学)
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Committee career (2)：
- 2017 - 現在 Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine Delegate
- 1999 - 2017 Medical and Pharmaceutical Society for WAKAN-YAKU Councillor
Awards (3)：
- 2015/10/10 - The Japanese Society of Pharmacognosy 2015年度日本生薬学会年会優秀発表賞 Japan
- 2013/09/07 - The Japanese Society of Pharmacognosy 平成25年度日本生薬学会論文賞 Japan
- 1998/08/29 - 和漢医薬学会 平成10年度和漢医薬学会奨励賞 糖質コルチコイド処置マウス赤血球膜のシアル酸代謝および桂枝茯苓丸の効果
Association Membership(s) (2)：
一般社団法人 和漢医薬学会
, 公益社団法人日本薬学会
