Rchr
J-GLOBAL ID：200901022217640743   Update date: Apr. 15, 2024

Hamada Akinobu

ハマダ アキノブ | Hamada Akinobu
Affiliation and department：
National Cancer Center Research Institute, Division of Molecular Pharmacology

About National Cancer Center Research Institute, Division of Molecular Pharmacology


Job title： Chief
Other affiliations (1)：
  • National Cancer Center
Homepage URL  (1)： https://www.ncc.go.jp/jp/ri/division/molecular_pharmacology/index.html
Research field  (5)： Clinical pharmacy ,  Clinical pharmacy ,  Tumor diagnostics and therapeutics ,  Pharmacology ,  Pharmaceuticals - chemistry and drug development
Research keywords  (5)： 創薬開発・薬効試験 ,  動物モデル・patient derived xenograft model ,  薬物動態・薬力学・薬理遺伝学 ,  個別化医療 ,  分子イメージング
Research theme for competitive and other funds  (8)：
  • 2021 - 2025 Development of a novel cell differentiation cancer therapy
  • 2013 - 2016 Personalized cancer chemotherapy: efficacy and safety based on pharmacokinetics and pharmacogenetics
  • 2009 - 2011 Novel strategy for development of suppressive drugs for kidney disease based on inhibition of metabolic production of uremic toxins
  • 2009 - 2011 Development of personalized medicine for cancer chemotherapy according to a variety of sensitivity and pharmacokinetics
  • 2007 - 2008 Development of an individualized therapy for establishing the optimal dosage by analysis of pharmacological gene
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Papers (172)：
  • Kiyoto Tsuchiya, Yoshiharu Hayashi, Shoraku Ryu, Hieu Trung Tran, Misao Takano, Kazuko Tanaka, Daisuke Mizushima, Shinichi Oka, Hiroyuki Gatanaga, Akinobu Hamada. Determination of intracellular tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots for pre-exposure prophylaxis adherence. Journal of Infection and Chemotherapy. 2024
  • Bunpei Miyazaki, Toshihide Ueno, Masanaka Sugiyama, Shinya Kojima, Ayumu Arakawa, Kayoko Tao, Kazuki Tanimura, Kouya Shiraishi, Shigehiro Yagishita, Shinji Kohsaka, et al. Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia. npj Precision Oncology. 2023. 7. 1
  • 寺崎 将, 田中 卓二, 柳下 薫寛, 濱田 哲暢, 坂本 康成, 肱岡 範, 森實 千種, 高橋 真美. フコキサンチンは患者由来腫瘍組織移植モデルにおける膵がんの腫瘍増殖を抑制する(Fucoxanthin inhibits tumor growth of pancreatic cancer in a patient-derived xenograft mouse model). 日本癌学会総会記事. 2023. 82回. 638-638
  • Trung Hieu Tran, Kiyoto Tsuchiya, Akira Kawashima, Koji Watanabe, Yoshiharu Hayashi, Shoraku Ryu, Akinobu Hamada, Hiroyuki Gatanaga, Shinichi Oka. Steady-state pharmacokinetics of plasma tenofovir alafenamide (TAF), tenofovir (TFV) and emtricitabine (FTC), and intracellular TFV-diphosphate and FTC-triphosphate in HIV-1 infected old Japanese patients treated with bictegravir/FTC/TAF. Global Health & Medicine. 2023. 5. 4. 216-222
  • Yuki Kojima, Emi Noguchi, Tomomi Yoshino, Shigehiro Yagishita, Shu Yazaki, Hitomi S Okuma, Tadaaki Nishikawa, Maki Tanioka, Kazuki Sudo, Tatsunori Shimoi, et al. Development of a Detection System for ESR1 Mutations in Circulating Tumour DNA Using PNA-LNA-Mediated PCR Clamping. Diagnostics (Basel, Switzerland). 2023. 13. 12
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MISC (153)：
  • 坂本 康成, 肱岡 範, 前原 耕介, 谷本 泉, 丸木 雄太, 永塩 美邦, 大場 彬博, 近藤 俊輔, 森実 千種, 柳下 薫寛, et al. 膵癌EUS-FNA検体からのPatient-derived xenograft(PDX)モデル作製の可能性について. 膵臓. 2019. 34. 3. A248-A248
  • Makoto Ohno, Mitsuhiro Hayashi, Yuko Matsushita, Yasuji Miyakita, Masamichi Takahashi, Erika Yamazawa, Natsuko Tsushita, Koichi Ichimura, Akinobu Hamada, Yoshitaka Narita. ISOCITRATE DEHYDROGENASE MUTATIONS AND INCREASED TISSUE 2-HYDROXYGLUTARATE CONCENTRATION MIGHT BE RELATED WITH SEIZURE ONSET IN PATIENTS WITH GLIOMAS. NEURO-ONCOLOGY. 2018. 20. 195-195
  • Mitsuhiro Hayashi, Yukari Tsubata, Hiroaki Aikawa, Kenji Tamura, Yasuhiro Fujiwara, Takeshi Isobe, Akinobu Hamada. Heterogeneous tissue distributions of erlotinib in lung cancer using MALDI mass spectrometry imaging. CANCER SCIENCE. 2018. 109. 902-902
  • Tadaaki Nishikawa, Mitsuhiro Hayashi, Kosei Hasegawa, Kan Yonemori, Kenji Tamura, Akinobu Hamada. Development of patient derived xenograft models for rare cancers. CANCER SCIENCE. 2018. 109. 172-172
  • Antibody-drug conjugates. 2017. 19. 4. 392-396
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Education (2)：
  • - 1992 Kumamoto University
  • - 1990 Kumamoto University School of Pharmacy
Professional career (1)：
  • Doctor of Pharmaceutical Science
Work history (7)：
  • 2022/04 - 現在 National Cancer Center Research institute Fundamental Innovative Oncology Core Center Director
  • 2012/04 - 現在 National Cancer Center
  • 2008 - 2011/03 Kumamoto University
  • 2005/08 - 2007/08 National Cancer Institute/National Institutes of Health Visiting Scientist
  • 2001/04 - 2005/07 Kumamoto University
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Committee career (4)：
  • 日本臨床薬理学会 評議員
  • 日本薬物動態学会 評議員
  • 日本臨床腫瘍学会 評議員
  • 日本癌学会 評議員
Awards (5)：
  • 2013/12 - 臨床薬理研究振興財団 学術論文賞
  • 2011/11 - 日本薬物動態学会 奨励賞 慢性骨髄性白血病治療薬イマチニブにおける個別化医療の実践と薬物動態変動要因の解析
  • 2007/05 - ASCO Merit Award Pharmacogenetics of organic anion transporting polypeptides (OATP): An association of a SLCO1B3 polymorphism with the overall survival in white Caucasian patients with androgen independent prostate cancer
  • 2007 - 臨床薬理研究振興財団 奨励賞 慢性リウマチに対する個別投与設計法の開発
  • 2004/12 - 日本薬学会 九州支部奨励賞 抗癌薬体内動態情報に基づく個別投与設計法の基盤構築に関する研究
Association Membership(s) (10)：
日本臨床薬理学会 ,  日本癌治療学会 ,  日本癌学会 ,  日本薬学会 ,  日本がん分子標的治療学会 ,  European Society for Medical Oncology ,  American Society for Clinical Pharmacology & Therapeutics ,  American Society of Clinical Oncology ,  American Association for Cancer Research ,  日本臨床腫瘍学会
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