Nobori Tsutomu

• 神経芽腫の発癌機構
• プリン代謝酵素(MTAP)異常を標的とした選択的化学療法
• p16遺伝子の転写調節
• Oncogenesis of Neuroblastoma
• Selective chemotherapy against cancer with purine metabolic enzyme (MTAP) abnomality
Transcriptional regulation of the p16 gene

• M Yamashiki, A Mase, Arai, I, XX Huang, T Nobori, A Nishimura, S Sakaguchi, K Inoue. Effects of the Japanese herbal medicine 'Inchinko-to' (TJ-135) on concanavalin A-induced hepatitis in mice. CLINICAL SCIENCE. 2000. 99. 5. 421-431
• Y Okugawa, H Wada, T Noda, M Sakakura, T Nakasaki, R Watanabe, H Deguchi, EC Gabazza, Y Mori, M Nishikawa, et al. Increased plasma levels of tissue factor pathway inhibitor-activated factor X complex in patients with disseminated intravascular coagulation. AMERICAN JOURNAL OF HEMATOLOGY. 2000. 65. 3. 210-214
• R Watanabe, H Wada, M Sakakura, Y Mori, T Nakasaki, Y Okugawa, EC Gabazza, T Hayashi, J Nishioka, K Suzuki, et al. Plasma levels of activated protein C protein C inhibitor complex in patients with hypercoagulable states. AMERICAN JOURNAL OF HEMATOLOGY. 2000. 65. 1. 35-40
• T Tsuchiya, K Sekine, S Hinohara, T Namiki, T Nobori, Y Kaneko. Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. CANCER GENETICS AND CYTOGENETICS. 2000. 120. 2. 91-98
• TJ M'soka, J Nishioka, A Taga, K Kato, H Kawasaki, Y Yamada, A Yu, Y Komada, T Nobori. Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay. LEUKEMIA. 2000. 14. 5. 935-940

ｍore...

• Method for inhibiting adenylosuccinate synthetase activity in malignant methylthioadenosine phosphorylase deficient cells. US Patent Number : 6,214,571 B1(共著)
• Method for the detection of the presence or absence of methylthioadenosine phosphorylase (MTAse) in a cell sample by detection of the presence or absence of MTAse encoding nucleic acid in the cell sample. US Patent Number : 5,942,393(共著)
• Method for selective methionine starvation of malignant cells in mammals. US Patent Number : 5,571,510(共著)

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• 2013 - 現在 日本遺伝子診療学会 理事
• 2012 - 現在 日本痛風・核酸代謝学会 理事
• 2011 - 現在 日本臨床化学会 監事
• 2000 - 日本検査血液学会 評議員

日本輸血学会 ,  日本検査血液学会 ,  日本遺伝子診療学会 ,  日本血液学会 ,  日本人類遺伝学会 ,  日本痛風・核酸代謝学会 ,  American Association for Concer Research ,  日本臨床検査医学会 ,  日本糖尿病学会 ,  日本臨床化学会 ,  日本癌学会