Kofuji Takefumi

Research field (3)： Psychiatry , Cell biology , Neuroscience - general

Research keywords (14)： neurotrophic factor , autism , neuroscience , glia , synapse , シナプス , グリア , 神経科学 , 自閉症 , 神経栄養因子 , 開口放出 , 神経伝達物質 , exocytosis , neurotransmitter

Research theme for competitive and other funds (6)：

2020 - 2023 Role of glial cells on the symptoms of neuropsychiatric disorders in syntaxin1 gene ablated mice
2016 - 2018 グリア細胞のシンタキシン1による神経細胞-グリア細胞間相互作用の解明
2013 - 2016 Role for ER stress responsive ER-Golgi SNARE in processing of Alzheimer`s disease-related protein and autophagy
2012 - 2015 シンタキシン1アイソフォームのシナプス伝達における機能分化
2007 - 2009 自閉症モデル動物としてのシンタキシン1遺伝子ノックアウトマウスの解析

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Papers (14)：

Tatsuya Mishima, Kenta Komano, Marie Tabaru, Takefumi Kofuji, Ayako Saito, Yoshikazu Ugawa, Yasuo Terao. Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes. Frontiers in cellular neuroscience. 2024. 18. 1361242-1361242
Tomonori Fujiwara, Takefumi Kofuji, Kimio Akagawa. Disturbance of the reciprocal-interaction between the OXTergic and DAergic systems in the CNS causes atypical social behavior in syntaxin 1A knockout mice. Behavioural brain research. 2021. 413. 113447-113447
Tatsuya Mishima, Tomonori Fujiwara, Takefumi Kofuji, Ayako Saito, Yasuo Terao, Kimio Akagawa. Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature-dependent seizures. Journal of neurochemistry. 2020
Tomonori Fujiwara, Takefumi Kofuji, Tatsuya Mishima, Kimio Akagawa. Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS. EUROPEAN JOURNAL OF NEUROSCIENCE. 2017. 46. 12. 2867-2874
Takefumi Kofuji, Yuko Hayashi, Tomonori Fujiwara, Masumi Sanada, Masao Tamaru, Kimio Akagawa. A part of patients with autism spectrum disorder has haploidy of HPC-1/syntaxin1A gene that possibly causes behavioral disturbance as in experimentally gene ablated mice. NEUROSCIENCE LETTERS. 2017. 644. 5-9

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MISC (15)：

T. Kofuji, T. Fujiwara, M. Sanada, T. Mishima, K. Akagawa. Glial cells from STX1B-KO mice were less effective on neuronal survival than WT. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 92-92
Tatsuya Mishima, Tomonori Fujiwara, Masumi Sanada, Takefumi Kofuji, Kimio Akagawa. A study on the neuronal phenotype of syntaxin1B knockout mice: Implication of differential role of syntaxin1A and syntaxin1B in synaptic transmission. NEUROSCIENCE RESEARCH. 2011. 71. E109-E109
Takefumi Kofuji, Tomonori Fujiwara, Masumi Sanada, Tatsuya Mishima, Kimio Akagawa. Distinct roles of HPC-1/STX1A and STX1B in neuronal survival. NEUROSCIENCE RESEARCH. 2011. 71. E221-E221
Tomonori Fujiwara, Masumi Sanada, Takefumi Kofuji, Tatsuya Mishima, Kimio Akagawa. A study on the phenotype of syntaxin1B knockout mice. NEUROSCIENCE RESEARCH. 2010. 68. E355-E355
Tatsuya Mishima, Tomonori Fujiwara, Takefumi Kofuji, Kimio Akagawa. Impaired induction of long-term potentiation in HPC-1/syntaxin 1A knockout mice may be due to altered catecholaminergic system. NEUROSCIENCE RESEARCH. 2010. 68. E341-E341

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Education (2)：

- 2002 Osaka University Graduate School, Division of Natural Science Biology
- 1997 Osaka University Faculty of Science Biology

Professional career (1)：

Doctor(Science), Master(Science) (Osaka University)

Association Membership(s) (6)：

Society for Neuroscience , JAPAN RADIOISOTOPE ASSOCIATION , 日本神経化学会 , 日本神経科学学会 , The Japanese Society for Neurochemistry , The Japan Neuroscience Society

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