Nishijima Hitoshi

ニシジマヒトシ | Nishijima Hitoshi

Affiliation and department：
Job title：講師

Research field (3)： Immunology , Molecular biology , Cell biology

Research keywords (4)： T細胞選択 , エピジェネティクス , 生化学 , 細胞生物学

Research theme for competitive and other funds (13)：

2019 - 2022 AIREを基軸とする自己免疫疾患の病態解明、ならびに新規治療法の開発
2018 - 2020 Studies on the mechanisms underlying autoimmune ambivalence
2017 - 2020 Analysis of AIRE-dependent gene-expression network which controls the differentiation of mTECs
2016 - 2019 Elucidation of the pathogenesis of autoimmune disease through the functional study of AIRE
2014 - 2017 Studies on the mechanisms for autoimmune phenotype in disease model mouse

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Papers (27)：

Hitoshi Nishijima, Mizuki Sugita, Natsuka Umezawa, Naoki Kimura, Hirokazu Sasaki, Hiroshi Kawano, Yasuhiko Nishioka, Minoru Matsumoto, Takeshi Oya, Koichi Tsuneyama, et al. Development of organ-specific autoimmunity by dysregulated Aire expression. Immunology and cell biology. 2022. 100. 5. 371-377
Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Kazuyoshi Hosomichi, Nobuko Akiyama, Taishin Akiyama, Takeshi Oya, Koichi Tsuneyama, Hideyuki Yoshida, Mitsuru Matsumoto. Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens. Journal of immunology (Baltimore, Md. : 1950). 2022. 208. 2. 303-320
Minoru Matsumoto, Koichi Tsuneyama, Junko Morimoto, Kazuyoshi Hosomichi, Mitsuru Matsumoto, Hitoshi Nishijima. Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms. International Immunology. 2020. 32. 2. 117-131
Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto. AIRE - The Autoimmune Regulator. eLS. 2019. 1-8
Junko Morimoto, Yumiko Nishikawa, Takumi Kakimoto, Kohei Furutani, Naoki Kihara, Minoru Matsumoto, Koichi Tsuneyama, Yuko Kozono, Haruo Kozono, Katsuto Hozumi, et al. Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G. The Journal of Immunology. 2018. 201. 11. 3244-3257

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MISC (9)：

横須賀忠, 若松英, 西嶋仁, 竹原朋宏, 西航, 塚本昌子, 町山裕亮. 【新規の創薬モダリティ細胞医薬細胞を薬として使う、新たな時代の基礎研究と治療法開発】第2章最先端基盤技術の動向と展望受容体シグナルの「デザイン」を評価するイメージング技術脂質二重支持膜. 実験医学. 2020. 38. 17. 2856-2862
横須賀忠, 若松英, 西嶋仁, 竹原朋宏, 西航, 塚本昌子, 町山裕亮. 受容体シグナルの「デザイン」を評価するイメージング技術. 実験医学新規の創薬モダリティ細胞医薬. 2020. 64-70
松本穣, 西嶋仁, 松本満, 常山幸一. ヒトAIREトランスジェニックマウスに認めた糖尿病抵抗性獲得機構の解析. 日本病理学会会誌. 2020. 109. 1. 358-358
西嶋仁, 松本満. 【免疫寛容研究のup-to-date】ヒトAIREを発現させたNODマウスに認められる自己免疫応答. 臨床免疫・アレルギー科. 2019. 71. 5. 490-496
西嶋仁, 毛利安宏, 西川裕美子, 松本満. AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化. 生化学. 2013. 85. 7. 600-600

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Books (2)：

遺伝子図鑑
悠書館 2013 ISBN:9784903487793
Premature chromatin condensation caused by loss of RCC1
Progress in Cell Cycle Research 2000

Education (3)：

1996 - 1999 Kyushu University Graduate School of Medical Sciences Department of Molecular Cell Biology
1994 - 1996 Kyushu University Faculty of Sciences Department of Biology
1990 - 1994 Kyushu University School of Sciences Department of Biology

Professional career (1)：

Work history (5)：

2020/05 - 現在 Tokyo Medical University Department of Immunology
2010/05 - 2020/04 Tokushima University Institute of Advanced Medical Science
2005/10 - 2010/04 National Institute of Genetics Integrated Genetics, Agricultural Genetics
2002/04 - 2005/09 Kyushu University Faculty of Medical Sciences
1999/04 - 2002/03 Japan Society for the Promotion of Science

Association Membership(s) (2)：

分子生物学会 , 免疫学会

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