Furukawa Kiyoshi

フルカワキヨシ | Furukawa Kiyoshi

Affiliation and department：
Homepage URL (1)： http://bio.nagaokaut.ac.jp/~furukawa-l/

Research field (4)： Cell biology , Functional biochemistry , Structural biochemistry , Home economics, lifestyle science

Research keywords (11)：動物-植物ハイブリッド糖鎖 , 感染症 , 糖鎖 , 細胞間相互作用 , 癌 , 増殖と分化 , carbohydrates , stem cells , atherosclerosis , cancer , Growth and differentiation

Research theme for competitive and other funds (29)：

2015 - 2017 Preparation of materials carrying with glycans and titanium dioxide to capture and eliminate specific pathogens
2011 - 2013 Regulation of transcription factor suppresses malignant properties of cancer cells with changes in glycosylation
2010 - 2012 Molecular mechanism of the growth inhibition of normal cells withgalectin-3
2007 - 2010 個体発生・老化における糖鎖の機能解析
2007 - 2009 機能性糖鎖を付加した生活用品・食品による健康維持

2007 - 2008 Study on the network of transcription factors that regulate the galactosylation of N-glycans in cancer cells

2006 - 2007 動物-植物ハイブリッド糖鎖の創出と住環境への応用

2004 - 2004 タンパク質の多様性獲得戦略の解明に基づいたゲノム情報の解読

2002 - 2003 Growth suppression of tumor cells by controlling the galactosylation of cell surface N-glycans

2001 - 2003 糖鎖遺伝子の発現制御による細胞の増殖分化の調節

2001 - 2003 Control of cell growth and differentiation by gene expression of glycosyltransferases

2001 - 2001 生体反応の高次構造認識における糖鎖コドンの化学的解明

2000 - 2001 Growth inhibition of tumor cells by transfection with β-1,4-glanctosyltransferase gene II or V.

1997 - 2000 Super-Biosystem Constructed by Cognitive Multidimensional Glyco-Molecules

1998 - 1999 Analysis of cellular functions of cells transfected with sense or antisense β-1,4-galactosyltransferase cDNA

1997 - 1999 高次認識糖鎖による細胞機能制御

1993 - 1996 糖鎖と増殖・分化

1995 - 1995 糖タンパク質糖鎖のN-アセチルガラクトサミニル化機構の解析

1994 - 1995 Structures and functions of the sugar chains of human leukocyte common antigen CD45

1993 - 1995 Glycobiology of immunoglobulin G

1994 - 1994 糖タンパク質糖質のN-アセチルガラクトサミニル化機構の解析

1990 - 1992 Analysis of the informations included in the sugar chains of glycoproteins,and studies on their functional mechanisms

1989 - 1989 糖タンパク質糖鎖の癌性変化とその臨床への応用

1989 - 1989 免疫グロブリンG糖鎖の病変に関する生化学的研究

1988 - 1988 糖タンパク質糖鎖の癌性変化とその臨床への応用

1987 - 1988 Studies on carbohydrate structures of plasma membrane blycoproteins in relation to the loss of cell adhesion.

1987 - 1987 糖タンパク質糖鎖の癌性変化とその臨床への応用

1986 - 1986 糖蛋白質糖類の癌性変化を応用した癌診断法並びに治療法開発の為の基礎的研究

1985 - 1986 Structural change of the sugar chains of serum IgG from Rheumatoid arthritis patients and its enzymatic background.

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Papers (27)：

Kiyoko Hirano, Yoshio Takada, Kiyoshi Furukawa. LacdiNAcylation of N-glycans in MDA-MB-231 human breast cancer cells results in changes in morphological appearance and adhesive properties of the cells. Histochemistry and Cell Biology. 2020. 153. 1. 17-26
Ogawa, S, Mizuno, M, Suzuki, M, Goto, K, Hirose, Y, Matsuda, A, Saito, T, Oguri, S, Furukawa, K. Isolation of a methylated mannose-binding protein from terrestrial worm Enchytraeus japonensis. Glycoconj. J. 2017. 34. 591-601
Hirano, K, Matsuda, A, Kuji, R, Nakandakari, S, Shirai, T, Furukawa, K. Enhanced expression of the 4-N-acetylgalacto¬saminyltransferase 4 gene impairs tumor growth of human breast cancer cells. Biochem. Biophys. Res. Commun. 2015. 461. 80-85
Ajisaka, K, Yuki, K, Sato, K, Ishii, N, Matsuo, I, Kuji, R, Miyazaki, T, Furukawa, K. Preferential binding of E. coli with type 1 fimbria to D-mannobiose with the Man(a)1→2Man structure. Biosci. Biotechnol. Biochem. 2015. 80. 128-134
Tagawa, M., Shirane, K., Yu, M., Sato, T., Furukawa, S., Mizuguchi, H., Kuji, R., Kawamura, K., Takahashi, N., Kato, K., Hayakawa, S., Sawada, S. and Furukawa, K. Enhanced expression of the b4-galactosyltransferase;gene impairs mammalian;tumor growth. Cancer Gene Therapy. 2014. 21. 219-227

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MISC (8)：

T. Sato, M. Takahashi, K. Furukawa. b-1,4-Galactosyltransferase III is involved in biosynthesis of highly branched N-lined oligosaccharides in WI38 human lung embryonic fibroblasts. Res. Commun. Biochem. and Cell & Molec. Biol. 2008. 12. 1-2. 61-71
Takeshi Sato, Kiyoshi Furukawa. Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase v gene involved in abnormal glycosylation characteristic of cancer cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 2007. 282. 38. 27702-27712
Tomomi Tadokoro, Kiyotaka Yamamoto, Iku Kuwahara, Hirosuke Fujisawa, Masahiko Ikekita, Akiyoshi Taniguchi, Takeshi Sato, Kiyoshi Furukawa. Preferential reduction of the alpha-2-6-sialylation from cell surface N-glycans of human diploid fibroblastic cells by in vitro aging. GLYCOCONJUGATE JOURNAL. 2006. 23. 5-6. 443-452
N Kitamura, M Ikekita, T Sato, Y Akimoto, Y Hatanaka, H Kawakami, M Inomata, K Furukawa. Mouse Na+/K+-ATPase beta 1-subunit has a K+-dependent cell adhesion activity for beta-GlcNAc-terminating glycans. Proc. Nat. Acad. Sci. USA. 2005. 102. 8. 2796-2801
Kitamura, N, Ikekita, M, Hayakawa, S, Funahashi, H, Furukawa, K. Suppression of the proliferation and neurite extension of human neuroblastoma cells on immobilized Psathyrella velutina lectin. J. Neurosci. Res. 2004. 75. 3. 384-390

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Patents (4)：

乳癌診断法
肺癌治療剤
Diagnosis of Breast cancer
Anti-cancer ding

Works (1)：

糖鎖遺伝子のクローニング
1995 - 1998

Professional career (1)：

Doctor of Science (The University of Tokyo)

Work history (7)：

2020/05 - 現在 Saitama Medical University Saitama Medical Center Division of Endocrinology and Diabetes Visiting Professor
2015/04 - 現在 The Noguchi Institute Academic Advisor
2005/04 - 2015/03 Nagaoka University of Technology Department of Biology Professor
1994/04 - 2005/03 Tokyo Metropolitan Institute of Gerontology Department of Biosignal Research Head of Department
1986/01 - 1994/03 The University of Tokyo The Institute of Medical Science Assistant Professor

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Committee career (4)：

2006 - 日本生化学会評議員
2005 - 日本基礎老化学会評議員
2005 - 日本糖質学会評議員
2002 - 日本細胞生物学会評議員

Awards (1)：

2004 - 東京都知事賞(発明・発見部門)

Association Membership(s) (7)：

米国糖鎖生物学会 , 日本基礎老化学会 , 日本分子生物学会 , 日本細胞生物学会 , 日本糖質学会 , 日本生化学会 , The Japanese Biochemical Society

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