Rchr
J-GLOBAL ID:200901023829804962   Update date: Apr. 12, 2024

Kikuchi Hidehiko

キクチ ヒデヒコ | Kikuchi Hidehiko
Affiliation and department:
Homepage URL  (1): https://kikuchi-biolchem.jimdo.com
Research field  (7): Food sciences ,  Applied microbiology ,  Home economics, lifestyle science ,  Functional biochemistry ,  Molecular biology ,  Immunology ,  Medical biochemistry
Research keywords  (14): Food manufacturing ,  post-translational modification ,  histone ,  chromatin ,  phagocyte ,  biodefence ,  gene targeting ,  phytochemical ,  gene expression ,  functional food ,  reactive oxygen species ,  epigenetics ,  ライフサイエンス領域 ,  Life science
Research theme for competitive and other funds  (28):
  • 2022 - 2027 摂取した食品成分等が大腸上皮細胞の活性酸素産生系Nox1に及ぼす影響の総括的研究
  • 2024 - 2025 腸管マクロファージの活性酸素産生能に及ぼすフィトケミカル類の影響の解明
  • 2022 - 2025 食後高血糖における新規細胞老化シグナルの増大およびその作用機序の総括的解明
  • 2023 - 2024 食品成分による自然免疫力(食細胞の活性酸素産生能力)増強の可能性を探る!
  • 2023 - 2024 Elucidation of the effects of phytochemicals on the superoxide-generating ability of intestinal macrophages
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Papers (57):
  • Hidehiko Kikuchi, Sayaka Fujita, Kaori Harata, Mayu Betto, Yuko Moriguchi, Fumiyuki Sanematsu, Harishkumar Madhyastha, Takefumi Sagara. Production and evaluation of a unique type of bread using inulin as the only carbohydrate source for bread fermentation with the inulinase-producing yeast, Kluyveromyces marxianus. Current Topics in Biotechnology. 2024. 14. 13-18
  • Hidehiko Kikuchi, Kaori Harata, Sumiko Akiyoshi, Takefumi Sagara, Harishkumar Madhyastha, Hitomi Mimuro, Futoshi Kuribayashi. Coffee diterpenes, cafestol and kahweol, display cytotoxicity and all-trans retinoic acid-induced superoxide generating activity-enhancing ability in U937 cells. Fundamental Toxicological Sciences. 2023. 10. 6. 233-240
  • Hidehiko Kikuchi. Production of N-acetyllactosamine using transgalactosylation activity of Aspergillus oryzae in Czapek-Dox liquid medium. 2023. 14. 1. 9-14
  • Hidehiko Kikuchi, Kaori Harata, Sumiko Akiyoshi, Takefumi Sagara, Harishkumar Madhyastha, Hitomi Mimuro, Futoshi Kuribayashi. Bifunctional activity of tangeretin (5,6,7,8,4'-pentamethoxyflavone) in suppression of cell growth and gene expression of the superoxide-generating system-related proteins in U937 cells. Fundamental Toxicological Sciences. 2022. 9. 5. 151-157
  • Hidehiko Kikuchi, Kaori Harata, Sumiko Akiyoshi, Takefumi Sagara, Harishkumar Madhyastha, Futoshi Kuribayashi. Potential role of green tea amino acid L-theanine in the activation of innate immune response by enhancing expression of cytochrome b 558 responsible for the reactive oxygen species-generating ability of leukocytes. Microbiology and Immunology. 2022. 66. 6. 342-349
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MISC (2):
Patents (3):
  • Bread and bread dough made by fermentation of inulin, and methods for producing the bread
  • Bread, Methods of bread making
  • レチノイン酸効果増強剤およびこれを用いたリンパ腫治療剤キット、並びに、活性酸素産生促進剤およびこれを用いた免疫賦活剤
Books (2):
  • Advances in Genetics Research vol.2(共著)
    Nova Science Publishers 2010 ISBN:9781608761005
  • Reviews and Protocols in DT40 Research(共著)
    Springer-Verlag 2006
Lectures and oral presentations  (52):
  • Potential role of green tea amino acid L-theanine in activation of innate immune response via enhancing expression of cytochrome b558 responsible for the reactive oxygen species-generating ability of leukocytes
    (2023)
  • 乳糖資化性酵母を用いた真正牛乳パンの製造と評価
    (第72回日本食品保蔵科学会大会 2023)
  • Urolithin A enhances the all-trans retinoic acid-induced superoxide generating ability via up-regulating the gp91-phox gene expression in U937 cells
    (2022)
  • Numbers and positions of hydroxyl groups in hydroxychalcones determine in cytotoxicity against human monoblastic leukemia U937 cells
    (2019)
  • レスベラトロールはgp91-phox遺伝子の発現増強を介してU937細胞のレチノイン酸誘導性スーパーオキシド産生能を強力に惹起する
    (第41回日本分子生物学会年会 2018)
more...
Works (4):
  • 東京大学医科学研究所拠点研究員
    2016 - 2017
  • 東京大学医科学研究所拠点研究員
    2013 - 2016
  • 東京大学医科学研究所拠点研究員
    2010 - 2013
  • 平原綾香/星つむぎの歌(Dreamusic MUCD-5125)
    2008 -
Education (3):
  • 1989 - 1993 東京大学大学院 医学系研究科 第三基礎医学専攻
  • 1987 - 1989 東北大学大学院 農学研究科
  • 1983 - 1987 Tohoku University Faculty of Agriculture
Professional career (3):
  • 博士(医学) (東京大学)
  • 農学修士 (東北大学)
  • 農学士 (東北大学)
Work history (8):
  • 2019/04 - 現在 Shokei University
  • 2018/04 - 現在 Shokei University Junior College
  • 2016/04 - 現在 Shokei University Junior College Shokei University Junior College
  • 2015/10 - 現在 Shokei University Junior College Department of Food and Nutrition Professor
  • 2007/04 - 2015/09 University of Miyazaki School of Medicine, Faculty of Medicine
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Committee career (3):
  • 2023/05 - 2024/03 公益財団法人日本高等教育評価機構 短期大学機関別認証評価評価員
  • 2021/04 - 2022/03 大学・短期大学基準協会 評価員
  • 2018/04 - 2020/03 全国栄養士養成施設協会 理事
Awards (3):
  • 2023/12 - International Journal of Molecular Sciences Outstanding Reviewer
  • 2020/01 - 日本教育公務員弘済会 個人研究助成学術賞
  • 2014/03 - Journal of Leukocyte Biology Highlighted Article
Association Membership(s) (6):
バイオテクノロジー研究推進会 ,  日本エピジェネティクス研究会 ,  日本分子生物学会 ,  日本生体防御学会 ,  日本生化学会 ,  日本農芸化学会
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