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J-GLOBAL ID：200901023842581549   Update date: Jan. 30, 2024

Sasaguri Toshiyuki

ササグリ トシユキ | Sasaguri Toshiyuki
Affiliation and department：
Kyushu University Faculty of Medical Sciences

About Kyushu University Faculty of Medical Sciences


Job title： Professor
Other affiliations (3)：
Homepage URL  (1)： http://www.med.kyushu-u.ac.jp/clipharm/
Research field  (3)： Cardiology ,  Internal medicine - General ,  Pharmacology
Research keywords  (21)： differentiation-inducing factor ,  臨床薬理 ,  腫瘍薬理 ,  一酸化窒素 ,  プロスタグランジン ,  血管細胞 ,  心不全 ,  狭心症 ,  動脈硬化 ,  高血圧 ,  心血管薬理 ,  clinical pharmacology ,  cancer chemotherapy ,  nitric oxide ,  prostaglandins ,  vascular cells ,  heart failure ,  angina ,  atherosclerosis ,  hypertension ,  cardiovascular pharmacology
Research theme for competitive and other funds  (14)：
  • 2017 - 2020 Identification of the tareget molecule for GSK-3 activator DIF towards clinical usage
  • 2011 - 2012 Identification of an inhibitor of mPGES-1 expression and its target molecule
  • 2008 - 2010 Pharmacogenetic studies on the influence of ALDH2 gene polymorphisms on the vasodilation induced by organic nitrates
  • 2004 - 2005 The clinical study on relationship between periodontal disease and atherosclerosis
  • 2002 - 2004 Studies on the signal transduction of difrentiation inducing factor and an application for the development of anti-cancer drug for early G_1 phase.
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Papers (78)：
  • Masaki Arioka, Fumi Seto-Tetsuo, Takeru Inoue, Koichi Miura, Shin Ishikane, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri. Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells. Life sciences. 2023. 335. 122278-122278
  • Takeru Inoue, Koichi Miura, Ruzhe Han, Fumi Seto-Tetsuo, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri. Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission. Journal of Pharmacological Sciences. 2023. 152. 1. 39-49
  • Fumi Seto-Tetsuo, Masaki Arioka, Koichi Miura, Takeru Inoue, Kazunobu Igawa, Katsuhiko Tomooka, Toshiyuki Sasaguri. DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells. International immunopharmacology. 2023. 117. 109913-109913
  • Akie Hirata, Shin Ishikane, Fumi Takahashi-Yanaga, Masaki Arioka, Tasuku Okui, Chinatsu Nojiri, Toshiyuki Sasaguri, Naoki Nakashima. Increased risk of metastasis in patients with incidental use of renin-angiotensin system inhibitors: a retrospective analysis for multiple types of cancer based on electronic medical records. Hypertension Research. 2022. 45. 12. 1869-1881
  • Fumi Seto-Tetsuo, Masaki Arioka, Koichi Miura, Takeru Inoue, Kazunobu Igawa, Katsuhiko Tomooka, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri. DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway. Oncogene. 2021. 40. 37. 5579-5589
ｍore...
MISC (70)：
  • Miki Nonaka, Sachio Morimoto, Kengo Hayamizu, Toshiyuki Sasaguri. Effect of pimobendan on heart failure at different stages in a mouse model of inherited cardiomyopathy. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 106P-106P
  • Ai Fujita, Fumi Takahashi, Sachio Morimoto, Toshiyuki Sasaguri. Celecoxib and 2,5-dimethyl-celecoxib inhibit cardiac hypertrophy induced by transverse aortic constriction in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 157P-157P
  • Miki Nonaka, Sachio Morimoto, Toshiyuki Sasaguri. Pimobendan has a preventive effect on compensated heart failure but increases the risk of sudden cardiac death at end-stage heart failure. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 241P-241P
  • Kentaro Jingushi, Fumi Takahashi, Toshihisa Nakamura, Toshiyuki Sasaguri. Differentiation-inducing factor-1 suppressed the expression of c-Myc in human colon cancer cell line, HCT-116. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 174P-174P
  • Miki Nonaka, Sachio Morimoto, Lei Li, Yutaka Kitamura, Toshiyuki Sasaguri. Therapeutic effect of pimobendan on end-stage heart failure in a mouse model of dilated cardiomyopathy. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 241P-241P
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Works (6)：
  • 血流刺激の情報伝達機構に関する研究
    1997 - 2001
  • Study on the signal transduction of blood flow
    1997 - 2001
  • 粘菌由来細胞分化誘導因子の情報伝達機構に関する研究
    1998 - 2000
  • Study on the signal transduction of dictyostelium differentiation-inducing factor
    1998 - 2000
  • 一酸化窒素の情報伝達機構に関する研究
    1995 - 1997
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Education (4)：
  • - 1987 Kyushu University
  • - 1987 Kyushu University Graduate School, Division of Medicine
  • - 1981 Kyushu University School of Medicine
  • - 1981 Kyushu University Faculty of Medicine
Professional career (1)：
  • (BLANK) (Kyushu University)
Work history (6)：
  • 1993 - 2001 国立循環器病センター研究所室長
  • 1993 - 2001 National Cardiovascular Center Research Institute, Division Head
  • 1990 - 1993 国立循環器病センター研究所科学技術特別研究員
  • 1990 - 1993 National Cardiovascular Center Research Institute, Researcher
  • 1986 - 1988 University of Oxford
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Committee career (4)：
  • 日本動脈硬化学会 評議員
  • 日本高血圧学会 評議員
  • 日本臨床薬理学会 評議員、理事
  • 日本薬理学会 学術評議員
Association Membership(s) (7)：
日本癌学会 ,  日本循環器学会 ,  日本内科学会 ,  日本動脈硬化学会 ,  日本高血圧学会 ,  日本臨床薬理学会 ,  日本薬理学会
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