KANO Koichiro

カノコウイチロウ | KANO Koichiro

Affiliation and department：
Job title： Professor

Research field (4)： Veterinary medicine , Animal production science , Developmental biology , Cell biology

Research keywords (9)： ECM , 細胞外マトリックス , tissue , differentiation , trans-differentiaiton , Tissue formation , dedifferentiation , transdifferentiation , Cell differentiation

Research theme for competitive and other funds (6)：

2019 - 2022 Mechanisms of cell differentiation and dedifferentiation by restructuring the cytoskeleton in vitro
2014 - 2017 Regenerative medicine using dedifferentiated fat cell-derived condition media and exosome
2011 - 2014 Development of cell-based therapy using dedifferentiated fat cells for treatment of intractable diseases in elderly patients
2010 - 2012 Integrated transcr iptomics for dedifferentiation and acquisitien of multipotency in porcine mature adipocytes and follicular granulosa cells.
1997 - 1999 Isolation of a new regulatory hormone of feeding and its central regulatory mechanisms

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Papers (82)：

Hirokatsu Sawada, Tomohiko Kazama, Yuki Nagaoka, Yoshinori Arai, Koichiro Kano, Hiroshi Uei, Yasuaki Tokuhashi, Kazuyoshi Nakanishi, Taro Matsumoto. Bone marrow-derived dedifferentiated fat cells exhibit similar phenotype as bone marrow mesenchymal stem cells with high osteogenic differentiation and bone regeneration ability. Journal of Orthopaedic Surgery and Research. 2023. in press. 1
Utsunomiya K, Maruyama T, Shimizu S, Matsumoto T, Endo M, Kobayashi H, Kano K, Abe M, Fukuda N. Implantation of dedifferentiated fat cells ameliorated antineutrophil cytoplasmic antibody glomerulonephritis by immunosuppression and increases in tumor necrosis factor-stimulated gene-6. Stem Cell Research & Therapy. 2022. 13. 1. 1-14
Megumi Uetaki, Nobuyuki Onishi, Yoshinao Oki, Takatsune Shimizu, Eiji Sugihara, Oltea Sampetrean, Takashi Watanabe, Hisano Yanagi, Kiyoshi Suda, Hiroya Fujii, et al. Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis. Molecular biology of the cell. 2022. 33. 9. mbcE21120609
Akita D, Kazama T, Tsukimura N, Taniguchi Y, Takahashi R, Arai Y, Tsurumachi-Iwasaki N, Yasuda H, Okubo T, Kano K, et al. Transplantation of Mature Adipocyte-Derived Dedifferentiated,Fat Cells Facilitates Periodontal Tissue Regeneration of Class II,Furcation Defects in Miniature Pigs. Materials. 2022. 15. 4. 1311-1311
Yasutaka Murata, Daisuke Obinata, Taro Matsumoto, Yuichiro Ikado, Koichiro Kano, Noboru Fukuda, Kenya Yamaguchi, Satoru Takahashi. Urethral injection of dedifferentiated fat cells ameliorates sphincter damage and voiding dysfunction in a rat model of persistence stress urinary incontinence. International Urology and Nephrology. 2022. 54. 4. 789-797

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MISC (13)：

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Patents (4)：

哺乳動物由来の脱分化脂肪細胞から神経細胞を製造する方法及び哺乳類動物由来の脱分化脂肪細胞から神経細胞への分化誘導キット
DIFFERENTIATED CELLS ORIGINATING IN PRECURSOR FAT CELLS AND METHOD OF ACQUIRING THE SAME
「前駆脂肪細胞株」
Transgenic animal having fatty acid desaturase and method of producing the same

Books (5)：

Transdifferentiation into osteoblasts of preadipocytes drived from mature adipocytes in vitro
Proceedings of the Final International Meeting for 21st Century Center of Excellence (COE) Program, Shoukadoh Book Sellers 2008
生殖補助医療(ART)胚培養の理論と実際“生命の誕生に向けて”
近代出版社 2005
生殖補助医療におけるコメディカルの役割:胚培養士(エンブリオロジスト)
産婦人科の世界 2004
In vitro systems for the analysis of the development of adipose tissue
Reproductive Biotechnology 2001
Glycosaminoglycans promote fertilization and embryonic development in pig
Reproductive Biology Update-Novel tools for assessment of environmental toxicity- 1998

Lectures and oral presentations (95)：

Hepatocytes derived from dedifferentiated fat cells exhibit functional characteristics of Zone3 hepatocytes in vitro
(第43回日本分子生物学会年会 2019)
成熟脂肪細胞に由来する脱分化脂肪細胞DFATはセロトニン作動性神経細胞に分化する
(第19回日本蛋白質科学学会年会・第71回日本細胞生物学会大会合同年次大会 2019)
"Transplantation of DFAT cells combined with a novel type I collagen-recombinant peptide scaffold for critical-size bone defects in rats.
(IADR/AADR/CADR General Session & Exhibition 2019)
脱分化脂肪細胞に由来する肝細胞は中心静脈周辺領域の肝細胞の特徴をもつ
(日本畜産学会第125回大会 2019)
公共データベースを利用した脱分化脂肪細胞における肝細胞分化制御因子の探索
(第70回日本細胞工学会大会 2018)

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Education (3)：

- 1994 Kobe University Graduate School, Division of National Science and Technology (except Gakushuin University, Konan University) Bioresource sciences
1989 - 1991 Kobe University Graduate School, Division of Agriculture Animal Sciences
1985 - 1989 Nihon University Faculty of Agriculture and Veterinary Medicine Animal Science

Professional career (2)：

Doctor of Agriculture (Kobe University)
Master of Agriculture (Kobe University)

Work history (6)：

2013/04 - 現在 Nihon University, College of Bioresource Sciences, Department of Animal Science, Proffessor
2007/04 - 2013/03 Nihon University, College of Bioresource Sciences, Department of Animal Science, Associate Proffessor
2002/04 - 2007/03 Nihon University, College of Bioresource Sciences, Department of Animal Science, Associate Proffessor
2005/10 - 2006/10 University of Melbourne Faculty of Veterinary Science Visiting Associate Professor
2000/04 - 2002/03 Nihon University, College of Bioresource Sciences, Department of Animal Science, Assistant Proffessor

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Committee career (3)：

2009/04 - 2015/03 関東畜産学会評議員
2001/04 - 2013/10 日本哺乳動物卵子学会評議員, 幹事, 編集委員, 事務局長
2009/04 - 2013/04 日本畜産学会代議員

Association Membership(s) (12)：

日本癌学会 , Society for the Study of Reproduction , 関東畜産学会 , 日本家禽学会 , 日本卵子学会 , 日本繁殖生物学会 , 日本畜産学会 , 日本再生医療学会 , 日本発生生物学会 , 日本細胞生物学会 , The American Society for Cell Biology , 日本分子生物学会

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