Rchr
J-GLOBAL ID：200901024679666198
Update date: Jan. 30, 2024
Masubuchi Yasuhiro
マスブチ ヤスヒロ | Masubuchi Yasuhiro
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Affiliation and department：
Chiba Institute of Science Faculty of Pharmacy, Laboratory of Clinical Pharmacy
About Chiba Institute of Science Faculty of Pharmacy, Laboratory of Clinical Pharmacy
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Detailed information
Job title：
Professor
Research field (3)：
Clinical pharmacy
, Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (9)：
臨床薬剤学
, 毒性学
, 薬物代謝
, 薬物動態
, 生物薬剤学
, toxicology
, drug metabolism
, Pharmacokinetics
, Biopharmaceutics
Research theme for competitive and other funds (23)：
2022 - 2025 The roles and regulation of damage-associated molecular pattern in drug-induced liver injury
1995 - 2016 薬物代謝酵素の不活性化に関する研究
1995 - 2016 薬剤性肝障害に関する研究
2012 - 2015 Gender as a susceptibility factor for drug-induced liver injury
2008 - 2010 Th1/Th2 balance as a determinant of drug-induced liver injury
2006 - 2007 Elucidation of Mechanism of Drug-Induced Liver Injury Based on Danger Hypothesis
2004 - 2005 Role of Mitochondria as Signal Sensors in Drug-Induced Liver Injury
2004 - 2005 MRP2 mediated defense against oxidative stress in liver
2002 - 2003 Involvement of cytokines in drug-induced liver injury
2001 - 2002 Evaluation of drug-induced hepatotoxicity by chemiluminescence and the role of MRP2 in the hepatotoxicity
2000 - 2001 薬剤性肝障害発現におけるシトクロムP450介在過程の同定
1999 - 1999 薬剤によるアレルギー性肝障害におけるシトクロムP450の役割に関する研究
1997 - 1999 The drug-induced hepatotoxicity
1997 - 1998 非ステロイド系抗炎症薬の肝毒性の評価とその発現機序に関する研究
1996 - 1996 交感神経β-受容体遮断薬プロプラノロールによる肝薬物代謝酵素活性変動の機構解明
1994 - 1995 THE ROLE OF CYP2D SUBFAMILY IN METABOLIC ACTIVATION OF THE DRUGS THAT CONTAIN NITROGEN ATOM IN THEIR CHEMICAL STRUCTURES
1994 - 1994 β遮断薬のシトクロムP450自殺基質としての作用機構と肝初回通過代謝における意義
1992 - 1993 Pharnacological and physiological sihnificance of cytochrome P450 isozymes in mammalian brain tissues
1991 - 1992 Molecular mechanism of non-linear first-pass metabolism
Study of Drug-induced Liver Injury
Study on Metabolic Activation of Drugs
Study on Inactivation of Cytochrome P450
Study on hepatotoxity of drugs
Show all
MISC (20)：
Yasuhiro Masubuchi, Junpei Nakayama, Yasuko Watanabe. Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine. TOXICOLOGY. 2011. 287. 1-3. 54-60
Yasuhiro Masubuchi, Shiori Sugiyama, Toshiharu Horie. Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury. CHEMICO-BIOLOGICAL INTERACTIONS. 2009. 179. 2-3. 273-279
Yasuhiro Masubuchi, Kanako Enoki, Toshiharu Horie. Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis. DRUG METABOLISM AND DISPOSITION. 2008. 36. 3. 597-603
Yasuhiro Masubuchi, Toshiharu Horie. Toxicological significance of mechanism-based inactivation of cytochrome P450 enzymes by drugs. CRITICAL REVIEWS IN TOXICOLOGY. 2007. 37. 5. 389-412
Yasuhiro Masubuchi, Toshiharu Horie. Toxicological significance of mechanism-based inactivation of cytochrome P450 enzymes by drugs. CRITICAL REVIEWS IN TOXICOLOGY. 2007. 37. 5. 389-412
ｍore...
Works (2)：
薬剤性肝障害の発現機構に関する研究
1999 -
Study on Mechanism of Drug-induced Hepatitis
1999 -
Professional career (1)：
Ph.D. (Chiba University)
Association Membership(s) (4)：
国際薬物動態学会
, 日本薬物動態学会
, 日本臨床薬理学会
, 日本薬学会
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