Rchr
J-GLOBAL ID：200901024717858438   Update date: Mar. 31, 2024

Takayama Hiromitsu

タカヤマ ヒロミツ | Takayama Hiromitsu
Affiliation and department：
Chiba University Faculty of Pharmaceutical Sciences

About Chiba University Faculty of Pharmaceutical Sciences


Job title： Full Professor
Homepage URL  (2)： http://www.p.chiba-u.jp/lab/skb/index.html ,  http://www.p.chiba-u.jp/lab/skb/index_e.html
Research field  (3)： Pharmaceuticals - chemistry and drug development ,  Environmental and pharmaceutical development resources ,  Pharmaceuticals - chemistry and drug development
Research keywords  (7)： Alkaloid ,  Medicinal Chemistry ,  Organic Chemistry ,  Natural Product Chemistry ,  医薬化学 ,  有機化学 ,  天然物化学
Research theme for competitive and other funds  (35)：
  • 2017 - 2021 Collective synthesis of monoterpenoid indole alkaloid using bioinspired reactions
  • 2017 - 2020 アルカロイド由来の新規有機不斉触媒と特定配列オリゴヌクレオチド認識分子の創製
  • 2016 - 2019 植物アルカロイドの探索と合成研究を基盤とした、疼痛および脳機能改善薬の創成
  • 2013 - 2017 Synthetic study of biologically active alkaloids using bio-inspired reactions
  • 2014 - 2017 天然オピオイド類の体内動態解明を目的としたSPECT用プローブの創製
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Papers (397)：
  • Ryu Mochizuki, Akane Kobayashi, Hiromitsu Takayama, Toshihiko Toida, Yasumitsu Ogra. Simultaneous determination of intracellular reduced and oxidized glutathiones by the König reaction. Analytical Methods. 2023. 15. 28. 3426-3431
  • Jichen Wang, Hideyuki Suzuki, Nanako Nakashima, Mariko Kitajima, Hiromitsu Takayama, Kazuki Saito, Mami Yamazaki, Naoko Yoshimoto. Identification of a regiospecific <i>S</i>-oxygenase for the production of marasmin in traditional medicinal plant <i>Tulbaghia violacea</i>. Plant Biotechnology. 2022. 39. 3. 281-289
  • Shinya Shiomi, Kaewsri Wilailak, Wataru Soutome, Hiromitsu Takayama, Mariko Kitajima, Hayato Ishikawa. Asymmetric Total Synthesis and Structure Elucidation of Huperzine H. The Journal of Organic Chemistry. 2022. 87. 5. 3730-3735
  • A. Saito, C. Fujita, N. Kogure, N. T. Vung, L. A. Hao, H. Takayama, M. Kitajima. New monoterpenoid indole alkaloids from Gelsemium elegans seeds. Tetrahedron. 2022. 104. 2. 132572-132572
  • T. Onozawa, N. Kogure, H. Takayama, M. Kitajima. Elucidation of Absolute Configuration of Ophiorrhiside A by Comparison of ECD Spectra with That of Model Chiral Compound Having a 1,2,3,4-Tetrahydro-β-carbolin-3-on Skeleton. Heterocycles. 2021. 102. 1. 35-43
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MISC (56)：
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Patents (19)：
  • Opioid analgesic
  • Indole Alkaloid Derivatives Having Opioid Receptor Agonistic Effect and Therapeutic Compositions and Methods Relating To Same.
  • Compound having activity of blocking NMDA receptor channel, and pharmaceutical agent using the same.
  • Compound having activity of blocking NMDA receptor channel, and pharmaceutical agent using the same.
  • Indole alkaloid derivatives having opioid receptor agonistic effect, and therapeutic compositions and methods relating to same
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Books (31)：
  • New Tide of Natural Product Chemistry
    Springer 2023 ISBN:9789819917136
  • 創薬化学のすゝめ
    日本薬学会 2023
  • Textbook for the Kampo and Natural Medicines
    2021
  • The Alkaloids: Chemistry and Biology Vol.82
    Academic Press 2019
  • 天然物の化学II
    東京化学同人 2018
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Works (8)：
  • 熱帯産薬用資源植物の化学的研究
    1996 - 2006
  • 抗ウイルス剤の開発研究
    1995 - 1999
  • アルカロイドの不斉全合成
    高山 廣光
  • 天然物由来の抗腫瘍剤の開発研究
  • 違法ドラッグの乱用防止策に関する研究
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Education (2)：
  • - 1982 Chiba University
  • - 1977 Chiba University Faculty of Pharmaceutical Sciences
Professional career (1)：
  • PhD
Work history (5)：
  • 2020/04 - 現在 千葉大学
  • 2004/04 - 2020/03 Chiba University Graduate School of Pharmaceutical Sciences
  • 1994/10 - 2004/03 Chiba University Faculty of Pharmaceutical Sciences
  • 1986/07 - 1994/09 Chiba University Faculty of Pharmaceutical Sciences
  • 1982/04 - 1984/03 Hannover University Institute of Organic Chemistry Posdoc. (Alexander von Humboldt Foundation)
Committee career (16)：
  • 2020/04 - 現在 富山大学和漢医薬学総合研究所 運営協議会委員
  • 2019/04 - 2021/03 日本薬学会 副会頭
  • 2018/04 - 2019/03 The Pharmaceutical Society of Japan Controller
  • 2018/04 - 2019/03 日本薬学会 監事
  • 2017/04 - 2019/03 日本薬学会 医薬化学部会長
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Awards (13)：
  • 2024/03 - 日本薬学会 日本薬学会名誉会員
  • 2018/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award
  • 2018/03 - 日本薬学会 学会賞
  • 2015/09 - The Japanese Society of Pharmacognosy The Japanese Society of Pharmacognosy Award
  • 2015/09 - 日本生薬学会賞
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Association Membership(s) (9)：
German Chemical Society ,  American Chemical Society ,  THE CHEMICAL SOCIETY OF JAPAN ,  国際複素環学会 ,  THE JAPANESE SOCIETY OF PHARMACOGNOSY ,  ドイツ化学会 ,  アメリカ化学会 (American chemical Society) ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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