2020 - 2023 Next generation non-invasive deep biological manipulation by combining biomolecular engineering and low physical energy logistics
2020 - 2023 試験管内分子進化と立体構造解析に基づいた赤色蛍光タンパク質の系譜拡張
2020 - 2022 Construction of photosynthetic zebrafish
2019 - 2022 Study on the remodeling of energy metabolism of cancer cells with a novel technology of isolating cells based on ATP concentrations
2018 - 2021 人工生体分子反応回路を埋め込んだ紙基板バイオアッセイ法の開発
2017 - 2020 Study of mitochondrial transporters branched-chain amino acids using genetically encoded fluorescent biosensors
2014 - 2019 Prevention, diagnosis and drug discovery of aging diseases using Pin1 related molecules
2016 - 2018 Quantitative analysis of ATP dynamics in photosynthetic organisms by a novel bioluminescence ATP biosensor
2015 - 2017 遺伝子コードされたFRET型酸素バイオセンサーの開発
2014 - 2017 Spatio-temporal analysis of extracellular ATP signaling of pancreatic islets
2013 - 2016 Functional analysis of pancreatic beta-cells in metabolic disorders using the fluorescent ATP probe gene transgenic mouse
2014 - 2015 Energy dynamics during kidney development, injury and regeneration
2014 - 2015 Development of efficient protein production system by photo-driven ATP regenerating vesicle
2012 - 2015 Development of neuroprotective treatment for incurable ocular diseases
2012 - 2014 Development of methods to visualize small conformational change of proteins inside cells
2011 - 2014 Analyses of the function and regulation of VCP, a major ATPase in the cells
2011 - 2012 Comprehensive quantification and visualization of energy metabolism in cell competition between dying and living cells.
2010 - 2012 Analysis of the roles of intracellular ATP during apoptosis by using the ATP imaging technique.
2010 - 2012 Real-time measurement of intracellular ATP concentration using novel fluorescent ATP probe.
蛍光生細胞イメージングを用いたエネルギー代謝の解析
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Papers (125)：
Hiromi Imamura, Shiho Otsubo, Mizuho Nishida, Norihiro Takekawa, Katsumi Imada. Red fluorescent proteins engineered from green fluorescent proteins. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 45. e2307687120
Pailin Chiaranunt, Kyle Burrows, Louis Ngai, Siu Ling Tai, Eric Y Cao, Helen Liang, Homaira Hamidzada, Anthony Wong, Julia Gschwend, Pascal Flüchter, et al. Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling. Science immunology. 2023. 8. 86. eabq4573
Jungmi Choi, Naoki Matoba, Daiki Setoyama, Daiki Watanabe, Yuichiro Ohnishi, Ryuto Yasui, Yuichirou Kitai, Aki Oomachi, Yutaro Kotobuki, Yoichi Nishiya, et al. The SGLT2 inhibitor empagliflozin improves cardiac energy status via mitochondrial ATP production in diabetic mice. Communications biology. 2023. 6. 1. 278-278
Masak Takaine, Hiromi Imamura, Satoshi Yoshida. High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast. eLife. 2022. 11
Anastassios Karagiannis, Thierry Gallopin, Alexandre Lacroix, Fabrice Plaisier, Juliette Piquet, Hélène Geoffroy, Régine Hepp, Jérémie Naudé, Benjamin Le Gac, Richard Egger, et al. Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity. eLife. 2021. 10
Genetically encoded fluorescent biosensors for understanding of metabolism at single cell level
(2nd WPI-NanoLSI Special Seminar -Frontiers in Chem-Bio- 2020)
